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Hermann Otto Mayr Matthias Rueschenschmidt Romain Seil David Dejour Anke Bernstein Norbert Suedkamp Amelie Stoehr 《International orthopaedics》2013,37(7):1263-1271
Purpose
The place of arthroscopic treatment in osteoarthritis of the knee has generated much controversy. A survey was initiated to collect the opinion of experienced surgeons.Methods
Of the 211 surgeons interviewed, 170 (80.6 %) replied to the electronic questionnaire. Respondents had at least ten years of experience in arthroscopy and currently perform more than 100 arthroscopies per year. Various indications and treatment modalities for arthroscopy in osteoarthritis of the knee had to be evaluated on a scale from “excellent” to “no indication”.Results
The respondents generally believe that an improvement is more likely in low-grade osteoarthritis (p < 0.001) and in neutral leg axis (p < 0.001). The outcome was rated better if symptoms had persisted for less than six months (p < 0.001) and for patients that were younger than 60 years (p < 0.001). Partial meniscectomy and notchplasty in cases of extension deficit were considered as successful treatment options. Debridement was an accepted indication, with an outcome mainly rated as fair. A majority saw no indication for joint lavage, arthroscopic treatment of arthrofibrosis and removal of osteophytes. The outcome appears to be poor if a bone edema is diagnosed on magnetic resonance imaging prior to arthroscopy. Only 55.9 % of respondents were comfortable with the current definition of osteoarthritis.Conclusions
Experienced arthroscopic surgeons all over Europe believe arthroscopy in osteoarthritis is appropriate, under certain conditions. The major task for surgeons is to select the right patients who are likely to benefit from this intervention. 相似文献75.
Romain Le Cozannet Athina Markou Ronald Kuczenski 《The European journal of neuroscience》2013,38(10):3487-3495
To better understand the neurobiology of methamphetamine (METH) dependence and the cognitive impairments induced by METH use, we compared the effects of extended (12 h) and limited (1 h) access to METH self‐administration on locomotor activity and object place recognition, and on extracellular dopamine levels in the nucleus accumbens and caudate‐putamen. Rats were trained to self‐administer intravenous METH (0.05 mg/kg). One group had progressively extended access up to 12‐h sessions. The other group had limited‐access 1‐h sessions. Microdialysis experiments were conducted during a 12‐h and 1‐h session, in which the effects of a single METH injection (self‐administered, 0.05 mg/kg, i.v.) on extracellular dopamine levels were assessed in the nucleus accumbens and caudate‐putamen compared with a drug‐naive group. The day after the last 12‐h session and the following day experimental groups were assessed for their locomotor activities and in a place recognition procedure, respectively. The microdialysis results revealed tolerance to the METH‐induced increases in extracellular dopamine only in the nucleus accumbens, but not in the caudate‐putamen in the extended‐access group compared with the control and limited‐access groups. These effects may be associated with the increased lever‐pressing and drug‐seeking observed during the first hour of drug exposure in the extended‐access group. This increase in drug‐seeking leads to higher METH intake and may result in more severe consequences in other structures responsible for the behavioral deficits (memory and locomotor activity) observed in the extended‐access group, but not in the limited‐access group. 相似文献
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Aurélie Mbeutcha Ilaria Lucca Vitaly Margulis Jose A. Karam Christopher G. Wood Michela de Martino Romain Mathieu Andrea Haitel Evanguelos Xylinas Luis Kluth Morgan Rouprêt Pierre I. Karakiewicz Alberto Briganti Michael Rink Malte Rieken Alon Z. Weizer Jay D. Raman Nathalie Rioux-Leclecq Christian Bolenz Karim Bensalah Yair Lotan Christian Seitz Mesut Remzi Shahrokh F. Shariat Tobias Klatte 《World journal of urology》2016,34(8):1155-1161
Background
Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.Methods
Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.Results
ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).Conclusions
ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.78.
Use of the retrograde limb of the internal mammary vein to avoid venous congestion in DIEP flap breast reconstruction: Further evidences of a reliable and time‐sparing procedure 下载免费PDF全文
79.
Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children 总被引:1,自引:0,他引:1
Junge S Kloeckener-Gruissem B Zufferey R Keisker A Salgo B Fauchere JC Scherer F Shalaby T Grotzer M Siler U Seger R Güngör T 《European journal of immunology》2007,37(11):3270-3280
CD31(+)CD45RA(+)RO(-) lymphocytes contain high numbers of T cell receptor circle (TREC)-bearing T cells; however, the correlation between CD31(+)CD4(+) lymphocytes and TREC during aging and under lymphopenic conditions has not yet been sufficiently investigated. We analyzed TREC, telomere length and telomerase activity within sorted CD31(+) and CD31(-) CD4(+) lymphocytes in healthy individuals from birth to old age. Sorted CD31(+)CD45RA(+)RO(-) naive CD4(+) lymphocytes contained high TREC numbers, whereas CD31(+)CD45RA(-)RO(+) cells (comprising < or =5% of CD4(+) cells during aging) did not contain TREC. CD31(+) overall CD4(+) cells remained TREC rich despite an age-related tenfold reduction from neonatal (100 : 1000) to old age (10 : 1000). Besides a high TREC content, CD31(+)CD45RA(+)RO(-)CD4(+) cells exhibited significantly longer telomeres and higher telomerase activity than CD31(-)CD45RA(+)RO(-)CD4(+) cells, suggesting that CD31(+)CD45RA(+)RO(-)CD4(+) cells represent a distinct population of naive T cells with particularly low replicative history. To analyze the value of CD31 in lymphopenic conditions, we investigated six children after allogeneic hematopoietic stem cell transplantation (HSCT). Reemerging overall CD4(+) as well as naive CD45RA(+)RO(-)CD4(+) cells predominantly expressed CD31 and correlated well with the recurrence of TREC 5-12 months after HSCT. Irrespective of limitations in the elderly, CD31 is an appropriate marker to monitor TREC-rich lymphocytes essentially in lymphopenic children after HSCT. 相似文献
80.
Romain Altwegg Raphaël Chiron Davide Caimmi Françoise Marquez Florence Jaouen Pierre Senesse Nicolas Flori 《Nutrition Clinique et Métabolisme》2018,32(2):90-94
The authors describe the case report of a patient with cystic fibrosis. The nutritional management is discussed during the different stages of disease treatment and progression. 相似文献