Covariance component models for multivariate binary traits in family data analysis

For family studies, there is now an established analytical framework for binary-trait outcomes within the generalized linear mixed models (GLMMs). However, the corresponding analysis of multivariate binary-trait (MBT) outcomes is still limited. Certain diseases, such as schizophrenia and bipolar disorder, have similarities in epidemiological features, risk factor patterns and intermediate phenotypes. To have a better etiological understanding, it is important to investigate the common genetic and environmental factors driving the comorbidity of the diseases. In this paper, we develop a suitable GLMM for MBT outcomes from extended families, such as nuclear, paternal- and maternal-halfsib families. We motivate our problem with real questions from psychiatric epidemiology and demonstrate how different substantive issues of comorbidity between two diseases can be put into the analytical framework.     

重组人表皮生长因子凝胶与康复新液治疗Ⅲ级放射性皮炎的疗效观察

目的观察重组人表皮生长因子凝胶与康复新液治疗Ⅲ级放射性皮炎的临床效果。方法将放射治疗过程中发生Ⅲ级放射性皮炎患者24例随机均分为2组。治疗组使用重组人表皮生长因子凝胶与康复新液对损伤部位进行换药,对照组使用1%冰片对损伤部位进行换药,2组均暴露皮肤。感染者全身使用抗生素治疗。结果治疗组平均创面愈合时间(4.0±1.5)d,对照组平均创面愈合时间(7.8±3.5)d。结论重组人表皮生长因子凝胶与康复新液用于临床治疗Ⅲ级放射性皮肤损伤效果明显,愈合时间短,可减轻和控制局部疼痛,提高患者的生活质量。     

The Banff Patellar Instability Instrument: validity and reliability of an Indonesian version

Background

The Banff Patellar Instability Instrument (BPII) is a valuable scoring tool for assessing patellofemoral instability in patients suffering from patellofemoral pain syndrome (PFPS). The BPII 2.0 is a shortened version of the BPII. However, there is no Indonesian edition of BPII 2.0 that has been validated. This study aimed to determine the validity and reliability of the Indonesian version of the BPII 2.0.

Materials and methods

This was a cross-sectional study that used a forward–backward translation protocol to create an Indonesian version of the BPII 2.0. Thirty patients with PFPS were given the questionnaires. The questionnaire's validity was evaluated by analyzing the correlation between score of each subscale and the overall score to the Indonesian version of the Kujala score using Pearson correlation coefficient, while the reliability was evaluated by measuring the internal consistency (Cronbach α) and test–retest reliability (intraclass correlation coefficient).

Results

The Indonesian version of BPII 2.0 and the Indonesian version of Kujala score had a strong Pearson correlation coefficient for construct validity. For all subscales, Cronbach α was 0.90–0.98, indicating adequate internal consistency. The test–retest reliability was high, with intraclass correlation coefficient ranging from 0.89 to 0.98 for all subscales. There was no difference in the Indonesian version of BPII 2.0 response between the first and second administration of the questionnaire which was taken 7 days afterward.

Conclusion

The Indonesian version of BPII 2.0 was determined to be valid and reliable and is therefore an objective instrument to evaluate patellofemoral instability in patients with PFPS in the Indonesian population.

     

意象对话技术对服刑人员进行短程干预的个案报告

目的探查在现阶段我国还没有条件对服刑人员提供广泛的长程心理干预的情况下，适合对服刑人员进行短程心理干预的心理咨询与治疗技术。方法采用意象对话技术对一名服刑人员进行一次性心理干预。结果本次心理干预在短时间内大致了解了来访者的一部分内心世界，并帮助其作出了一些积极的改变。结论使用意象对话技术对服刑人员进行短程心理干预具有特殊的优势和良好的应用前景。