全文获取类型
收费全文 | 178310篇 |
免费 | 11867篇 |
国内免费 | 702篇 |
专业分类
耳鼻咽喉 | 2507篇 |
儿科学 | 4896篇 |
妇产科学 | 3449篇 |
基础医学 | 23112篇 |
口腔科学 | 3559篇 |
临床医学 | 17491篇 |
内科学 | 38048篇 |
皮肤病学 | 2809篇 |
神经病学 | 17998篇 |
特种医学 | 6261篇 |
外国民族医学 | 14篇 |
外科学 | 26529篇 |
综合类 | 2345篇 |
现状与发展 | 3篇 |
一般理论 | 202篇 |
预防医学 | 13274篇 |
眼科学 | 4773篇 |
药学 | 11554篇 |
中国医学 | 206篇 |
肿瘤学 | 11849篇 |
出版年
2023年 | 643篇 |
2022年 | 729篇 |
2021年 | 2869篇 |
2020年 | 1765篇 |
2019年 | 2891篇 |
2018年 | 3407篇 |
2017年 | 2462篇 |
2016年 | 2870篇 |
2015年 | 3467篇 |
2014年 | 5124篇 |
2013年 | 7894篇 |
2012年 | 11422篇 |
2011年 | 12284篇 |
2010年 | 6857篇 |
2009年 | 6323篇 |
2008年 | 11556篇 |
2007年 | 12330篇 |
2006年 | 11827篇 |
2005年 | 12186篇 |
2004年 | 11579篇 |
2003年 | 11040篇 |
2002年 | 10664篇 |
2001年 | 1499篇 |
2000年 | 1148篇 |
1999年 | 1602篇 |
1998年 | 2332篇 |
1997年 | 2027篇 |
1996年 | 1706篇 |
1995年 | 1584篇 |
1994年 | 1429篇 |
1993年 | 1360篇 |
1992年 | 1051篇 |
1991年 | 964篇 |
1990年 | 845篇 |
1989年 | 826篇 |
1988年 | 848篇 |
1987年 | 735篇 |
1986年 | 846篇 |
1985年 | 923篇 |
1984年 | 1229篇 |
1983年 | 1180篇 |
1982年 | 1641篇 |
1981年 | 1484篇 |
1980年 | 1367篇 |
1979年 | 754篇 |
1978年 | 887篇 |
1977年 | 771篇 |
1976年 | 685篇 |
1975年 | 562篇 |
1974年 | 585篇 |
排序方式: 共有10000条查询结果,搜索用时 546 毫秒
991.
992.
Theodore A. Henderson Robert W. Rhoades Carol A. Bennett-Clarke Pat A. Osborne Eugene M. Johnson Mark F. Jacquin 《The Journal of comparative neurology》1993,336(2):243-260
Prior studies indicate that neonatal nerve injury kills many trigeminal (V) first- and second-order cells, and interrupts pattern formation in the brainstem and cerebral cortex. Yet it is not known whether effects upon cell survival and pattern formation are causally related. To determine whether axotomized V ganglion cells can be rescued by an exogenous trophic agent, rats received 5 mg/kg of nerve growth factor (NGF) prior to, and every day after, infraorbital nerve section on the day of birth until sacrifice on postnatal day (PND) 1, 3, 5, 7, or 14. Other animals received identical lesions without NGF. Ganglion cell numbers were significantly reduced by PNDl in pups not given NGF, while NGF-treated rats displayed no significant cell loss through PND7. However, NGF did not permanently rescue V neurons because ganglion cell numbers were reliably reduced by PND14. Cell numbers in V nucleus principalis were reduced by PNDl in pups not given NGF, while NGF-treated animals displayed no cell loss through PND14. NGF's rescue of second-order cells is probably an indirect effect of NGF actions upon V ganglion cells because, in other newborns, NGF failed to maintain principalis cells after direct lesion of the left V ganglion. To determine whether preventing cell death permits whisker-related pattern formation, other rats also received NGF prior to and after infraorbital nerve section at birth. After 3–14 days, patterns were assessed in the brainstem and cortex with cytochrome oxidase histochemistry and serotonin immunocytochemistry. Whisker-related patterns failed to develop as in cases not given NGF. These data indicate that communication with the periphery is necessary for the maintenance of central whisker-related patterns. They also suggest that V ganglion cells can be rescued, albeit temporarily, from rapid injury-induced death by NGF, thereby delaying injury-induced cell death in nucleus principalis. However, the mechanism(s) responsible for injury-induced pattern alterations in the developing V system remains to be elucidated. © 1993 Wiley-Liss, Inc. 相似文献
993.
994.
In the past decade, speech-language pathologists have taken a leading role in the management of services for patients with oropharyngeal dysphagia. This article presents the historical perspective of this role, the rationale for assuming the responsibility, and suggests directions for continued involvement. 相似文献
995.
Robert A. Hauser F. Reed Murtaugh Kauser Akhter Michael Gold C. W. Olanow 《Journal of neuroimaging》1996,6(4):222-226
Corticobasal degeneration (CBD) is an adult–onset, progressive parkinsonian syndrome with strikingly asymmetrical features, and signs and symptoms referable to both cerebral cortex and basal ganglia. Although once considered rare, it is now recognized with increasing frequency during life. Eight patients with clinically diagnosed CBD and 8 age– and sex–matched patients with Parkinson's disease underwent high–field–strength magnetic resonance imaging (MRI) of the brain. MRIs were graded by a blinded neuroradiologist using a semiquantitative (0–3) scale. MRI of patients with CBD revealed significantly greater T2–weighted signal hypointensity in the putamena and globi pallidi, and ventricular enlargement. When specifically sought, asymmetrical cortical atrophy was identified in 5 of 8 CBD patients. Increased T2–weighted lenticular signal hypointensity, ventricular enlargement, and asymmetrical cortical atrophy are supportive MRI findings of CBD. 相似文献
996.
We used an in vitro model similar to kindling to examine the processes underlying epileptogenesis. A 60 Hz train was applied every 5–10 min to the Schaffer collateral pathways in guinea pig hippocampal slices until epileptiform bursting was elicited in the CA3 region. The resultant alterations in both spontaneous and evoked activities were studied using intracellular recordings from CA3 pyramidal cells. An attempt was made to elucidate the synaptic modifications responsible for the conversion to this state of enhanced excitability. Analyses revealed that the emergence of epileptiform discharge was accompanied by a long-term depression of evoked inhibitory conductances. This tetanus-induced reduction of inhibition involved both the early and late phases of the evoked hyperpolarization, suggesting modification of both the GABAA and GABAB receptor-mediated events. Previous studies have suggested that NMDA receptor activation plays an important role in the induction of epileptiform activity in this model. Our data, showing that depression of inhibition can be induced in the presence of CNQX, is consistent with this hypothesis. The parallel development of long-term depression of inhibition and epileptiform bursting following tetanic stimulation suggests that plasticity of the inhibitory transmission process is a potential source of vulnerability contributing to epileptogenesis. 相似文献
997.
998.
The author outlines some common physiological causes of depression in the elderly, as well as some of the common manifestations of depressive symptoms seen in individuals within this age group. 相似文献
999.
Robert K. McNamara R. Duncan Kirkby Gregory E. dePape Ronald W. Skelton Michael E. Corcoran 《Hippocampus》1993,3(2):149-152
There is some controversy about the role of long-term potentiation (LTP) in spatial learning. The authors have found that triggering generalized kindled seizures with stimulation of the perforant path disrupts spatial learning in the Morris water maze but that kindling per se does not affect spatial learning. It is suggested that abnormal electrical activity induced by high-frequency stimulation of the perforant path may have been responsible for the disruption of spatial learning previously attributed to LTP saturation. 相似文献
1000.
Mario Perez-Reyes MD Robert E. Hicks PhD Jean Bumberry BS A. Robert Jeffcoat PhD C. Edgar Cook PhD 《Alcoholism, clinical and experimental research》1988,12(2):268-276
This is a report of the results of a placebo-controlled study in which the effects of the interaction between ethanol and marihuana on drug plasma concentrations, subjective ratings of intoxication, heart rate acceleration, and psychomotor performance were investigated. Six healthy, male, paid volunteers, moderate users of ethanol and marihuana, participated in the study. Ethanol (0.42 g/kg, 0.85 g/kg, or placebo) was administered over a 30-min interval. Fifteen minutes later the subjects smoked, in their customary manner, NIDA cigarettes containing 2.4% or 0.0004% (placebo) delta-9-tetrahydrocannabinol (THC). Each subject was tested in a single-blind, latin-square crossover design with the following six conditions: placebo ethanol/placebo marihuana; low dose ethanol/placebo marihuana; high dose ethanol/placebo marihuana; placebo ethanol/marihuana; low dose ethanol/marihuana; and high dose ethanol/marihuana. The variables measured in the study were: (a) subjective rating of ethanol and/or marihuana intoxication; (b) heart rate; (c) accuracy and latency of response in the Simulator Evaluation of Drug Impairment (SEDI) task; (d) blood ethanol concentration by gas chromatography; and (e) plasma concentration of THC by radioimmunoassay. The results indicate that the decrements due to ethanol in performance of skills necessary to drive an automobile were significantly enhanced by marihuana in an additive and perhaps synergistic manner. The administration of ethanol prior to marihuana smoking did not produce significant effects on the subjective rating of "high," heart rate acceleration, or THC plasma concentration. 相似文献