全文获取类型
收费全文 | 3131篇 |
免费 | 336篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 97篇 |
妇产科学 | 51篇 |
基础医学 | 474篇 |
口腔科学 | 129篇 |
临床医学 | 399篇 |
内科学 | 692篇 |
皮肤病学 | 86篇 |
神经病学 | 287篇 |
特种医学 | 95篇 |
外科学 | 387篇 |
综合类 | 23篇 |
一般理论 | 3篇 |
预防医学 | 261篇 |
眼科学 | 42篇 |
药学 | 214篇 |
中国医学 | 6篇 |
肿瘤学 | 185篇 |
出版年
2023年 | 65篇 |
2022年 | 43篇 |
2021年 | 96篇 |
2020年 | 71篇 |
2019年 | 76篇 |
2018年 | 126篇 |
2017年 | 120篇 |
2016年 | 123篇 |
2015年 | 131篇 |
2014年 | 144篇 |
2013年 | 255篇 |
2012年 | 219篇 |
2011年 | 227篇 |
2010年 | 137篇 |
2009年 | 87篇 |
2008年 | 130篇 |
2007年 | 155篇 |
2006年 | 146篇 |
2005年 | 123篇 |
2004年 | 147篇 |
2003年 | 107篇 |
2002年 | 100篇 |
2001年 | 32篇 |
2000年 | 12篇 |
1999年 | 16篇 |
1998年 | 18篇 |
1997年 | 13篇 |
1996年 | 19篇 |
1995年 | 25篇 |
1994年 | 11篇 |
1992年 | 21篇 |
1991年 | 17篇 |
1989年 | 13篇 |
1988年 | 12篇 |
1987年 | 12篇 |
1986年 | 20篇 |
1985年 | 14篇 |
1984年 | 23篇 |
1982年 | 16篇 |
1981年 | 11篇 |
1980年 | 12篇 |
1979年 | 15篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1974年 | 10篇 |
1955年 | 38篇 |
1954年 | 88篇 |
1949年 | 20篇 |
1948年 | 17篇 |
1943年 | 11篇 |
排序方式: 共有3470条查询结果,搜索用时 125 毫秒
51.
52.
53.
54.
Ulrika Håkansson Kerstin Söderström Reidulf Watten Finn Skårderud Merete Glenne Øie 《Attachment & human development》2018,20(2):181-207
Having a substance use disorder (SUD) may adversely affect caregiving capacities. Reflective functioning (RF) and executive functioning (EF) are both important capacities for sensitive parenting, and are often impaired in a SUD. Only a few studies have explored the possible association between the two phenomena. In this study, we used a neuropsychological test battery to assess EF, and the Parent Development Interview to assess RF in a sample of mothers with a SUD (N = 43). Although parental RF (PRF) was associated with EF, when controlled for intelligence (IQ) and mental health, there was no significant association between EF and PRF. Mental health, however, showed a significant negative association with PRF. Splitting the group in two based on PRF level, mothers with a negative to low PRF exhibited more severe difficulties in SUD-related aspects, as well as in several EF components, compared to mothers with an adequate to high PRF, highlighting the association between EF and PRF. The results from this study contribute to enhance our understanding of the dynamics underlying vulnerability in PRF that mothers with small children may experience. We suggest EF to be a prerequisite for adequate PRF, and for interventions to be customized accordingly regarding parents with a SUD. 相似文献
55.
Risa Chaisuparat Somsri Rojanawatsirivej Somchai Yodsanga 《Pathology oncology research : POR》2013,19(2):189-193
Ribosomal protein S6 (RPS6), a downstream effector of the mammalian target of rapamycin pathway (mTOR), is activated in many cancers including oral squamous cell carcinoma (OSCC). However, the role of RPS6 in the progression of potentially malignant disorders (or premalignant lesions) to OSCC is unknown. The purpose of this study was to examine the expression of RPS6 in epithelial dysplasia and OSCC to determine the association of RPS6 in tumor progression. In our study, an immunohistochemical analysis of RPS6 was performed on tissue microarrays containing 30 control samples, 15 epithelial dysplasia cases, and 53 OSCC cases. Correlations between the clinicopathologic features of OSCC and RPS6 expression were analyzed using the Chi-square test. We found RPS6 phosphorylation (p-RPS6) in 15/30 (50 %) control normal oral mucosa samples, 15/15 (100 %) epithelial dysplasia cases, and 47/53 (88.68 %) OSCC cases. The frequency of p-RPS6 in epithelial dysplasia or OSCC showed a statistically significant difference compared to control (P?<?0.001). However, there were no significant correlations between p-RPS6 and the clinicopathologic features of OSCC. Our findings suggest that RPS6 activation is associated with the early events of tumor progression, suggesting p-RPS6 as a potential marker for early detection of oral cancer. 相似文献
56.
Junko Daito Yoshinori Harada Ping Dai Yoshihisa Yamaoka Risa Tamagawa-?Mineoka Norito Katoh Tetsuro Takamatsu 《ACTA HISTOCHEMICA ET CYTOCHEMICA》2014,47(2):67-74
Activated platelets form platelet–leukocyte aggregates in the circulation in inflammatory diseases. We investigated whether activated platelets in inflamed skin tissues are phagocytized and removed by neutrophils. To investigate the kinetics of platelets and neutrophils, we immunohistochemically examined the spatiotemporal distribution of them in a murine model of 2,4,6-trinitro-1-chlorobenzene (TNCB)-induced dermatitis by using confocal and structured illumination microscopy. Four hours after elicitation, aggregates of CD41-positive platelets were adhered to CD31-positive endothelial cells within the vessels, and CD62P and PF4, markers of activated platelets, were expressed on platelet aggregates. At 8 hour post-elicitation, fragmented CD41-positive platelets were located both inside and outside vessels. Twenty-four hours after elicitation, the number of Ly-6G-positive neutrophils ingesting fragmented CD41-positive platelets outside vessels was increased, and CD62P and PF4 expression on the phagocytosed platelets was no longer observed. Disc-shaped CD41-positive platelets were not found outside vessels at any time during the experiment. Our data revealed that aggregates of activated platelets inside vessels were ingested and removed by neutrophils in the early stage of TNCB-induced dermatitis, suggesting that the process of removal of activated platelets by neutrophils may play an important role not only in the early phase of skin inflammation but also in other types of acute inflammation. 相似文献
57.
58.
59.
Risa Tamagawa-Mineoka Naoko Yasuoka Mayumi Ueta Norito Katoh 《Allergology international》2018,67(3):388-391
Background
Topical corticosteroids (TCS) can induce adverse effects, such as skin atrophy. Although TCS can cause increases in intraocular pressure (IOP), the effects of daily TCS use on IOP have not been fully elucidated. We evaluated the clinical doses of TCS and the change in the IOP during the daily treatment of atopic dermatitis (AD).Methods
We collected clinical data on a total of 65 patients who were diagnosed with AD and underwent 2 or more IOP measurements at our hospital.Results
Mean monthly facial steroid volumes of ≤11.8 g and ≤15.0 g of TCS were applied to 90% of the patients aged 2–12 years and those aged ≥13 years, respectively. During the treatment, there were no TCS-related increases in IOP in any patient.Conclusions
Our study suggests that TCS might not cause increases in IOP at the abovementioned doses. However, the IOP of steroid responders is known to be highly responsive to steroids. Therefore, patients who have steroids applied to their eyelids had better undergo regular IOP measurements at ophthalmological clinics. 相似文献60.
OBJECTIVE: Surgical cure of Cushing's syndrome (CS) is followed by adrenocortical insufficiency, which may be long-lasting. The aim was to elucidate recovery of adrenocortical function, defined as a normal cortisol response to ACTH stimulation, and the relation to ACTH in patients cured for CS due to pituitary Cushing's disease (CD) or adrenal (AA) adenomas. DESIGN: A retrospective study including 32 patients considered surgically cured for CS (18 CD, 14 AA). RESULTS: Twelve (67%) patients with CD recovered within median 24 months (range 7 months-4(1)/(2) years) whereas six did not recover within 3-12 years. Plasma ACTH (p-ACTH) at time of recovery was not different from p-ACTH in patients not recovering (P = 0.9). Eleven (79%) patients with AA recovered within 24 months (10 months-4 years) whereas three did not recover within 4-10 years. p-ACTH at time of recovery was higher compared to patients not recovering (P < 0.04). No differences were observed comparing CD and AA patients concerning preoperative 24-h urinary free cortisol (UFC) excretion, postoperative unstimulated s-cortisol or recovery time. By contrast, p-ACTH measured at time of recovery was higher in AA compared to CD (median 12.3 vs. 4.6 pmol/l) (P < 0.001), whereas plasma dehydroepiandrosterone sulfate (p-DHEAS) was lower in AA compared to CD (median 300 vs. 1500 nmol/l) (P = 0.02). CONCLUSION: Recovery of secondary adrenal insufficiency is a slow process in both CD and AA. ACTH measured at time of recovery was significantly higher and DHEAS significantly lower in patients with AA compared to CD, which may suggest different mechanisms of the recovery process and different set points in the glucocorticoid feedback inhibition of ACTH secretion. 相似文献