全文获取类型
收费全文 | 1957篇 |
免费 | 117篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 269篇 |
儿科学 | 35篇 |
妇产科学 | 16篇 |
基础医学 | 305篇 |
口腔科学 | 12篇 |
临床医学 | 442篇 |
内科学 | 389篇 |
皮肤病学 | 9篇 |
神经病学 | 77篇 |
特种医学 | 10篇 |
外科学 | 285篇 |
综合类 | 25篇 |
预防医学 | 82篇 |
眼科学 | 1篇 |
药学 | 42篇 |
中国医学 | 5篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 12篇 |
2022年 | 15篇 |
2021年 | 30篇 |
2020年 | 25篇 |
2019年 | 37篇 |
2018年 | 32篇 |
2017年 | 37篇 |
2016年 | 46篇 |
2015年 | 65篇 |
2014年 | 71篇 |
2013年 | 88篇 |
2012年 | 139篇 |
2011年 | 135篇 |
2010年 | 64篇 |
2009年 | 60篇 |
2008年 | 107篇 |
2007年 | 107篇 |
2006年 | 104篇 |
2005年 | 110篇 |
2004年 | 110篇 |
2003年 | 105篇 |
2002年 | 105篇 |
2001年 | 73篇 |
2000年 | 59篇 |
1999年 | 50篇 |
1998年 | 15篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 9篇 |
1993年 | 16篇 |
1992年 | 31篇 |
1991年 | 21篇 |
1990年 | 25篇 |
1989年 | 19篇 |
1988年 | 12篇 |
1987年 | 16篇 |
1986年 | 16篇 |
1985年 | 12篇 |
1984年 | 6篇 |
1983年 | 13篇 |
1982年 | 8篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1973年 | 4篇 |
1971年 | 8篇 |
1970年 | 3篇 |
1966年 | 5篇 |
排序方式: 共有2090条查询结果,搜索用时 0 毫秒
41.
D. Karalapillai D. Story G. K. Hart M. Bailey D. Pilcher A. Schneider M. Kaufman D. J. Cooper R. Bellomo 《Anaesthesia》2013,68(6):605-611
Using a multicentre adult patient database from Australia and New Zealand, we obtained the lowest and highest temperature in the first 24 h after admission to the intensive care unit after elective non‐cardiac surgery. Hypothermia was defined as core temperature < 36 °C; transient hypothermia as a temperature < 36 °C that was corrected within 24 h, and persistent hypothermia as hypothermia not corrected within 24 h. We studied 50 689 patients. Hypothermia occurred in 23 165 (46%) patients, was transient in 22 810 (45%), and was persistent in 608 (1.2%) patients. On multivariate analysis, neither transient (OR = 1.07, 95% CI 0.96–1.20) nor persistent (OR = 1.50. 95% CI 0.96–2.33) hypothermia was independently associated with increased hospital mortality. 相似文献
42.
43.
Lupi A Secco GG Rognoni A Rossi L Lazzero M Nardi F Rolla R Bellomo G Bongo AS Di Mario C 《Journal of thrombosis and thrombolysis》2012,33(4):308-317
Plasma fibrinogen levels influence restenosis following elective percutaneous coronary intervention (PCI) for stable angina.
It is unknown whether the same is true in the setting of primary PCI. The aim of the study was therefore to assess whether
fibrinogen levels were associated to 6-month in-stent restenosis (ISR) in STEMI patients undergoing successful primary PCI.
From January 2003 to October 2004, 267 patients were admitted to our Institution for STEMI and treated by primary PCI. Of
these, 171 patients met the inclusion criteria and were enrolled in our study. Fibrinogen levels were assessed at admission,
12 h, 24 h, 48 h, 72 h following PCI and at discharge. Six-month angiographic follow-up was 100% complete. Subjects with 6-month
ISR showed higher fibrinogen levels than patients without ISR. Patients in the upper fibrinogen tertile showed a higher 6-month
incidence of symptoms and/or inducible myocardial ischemia (27.1% vs. 7.1%, P = 0.006) and a larger late lumen loss (1.3 ± 0.8 vs. 1.0 ± 0.9 mm, P = 0.049). Logistic regression analysis demonstrated a significant and independent association between fibrinogen levels and
ISR. Our study suggests that increased plasma fibrinogen levels are related to ISR in STEMI patients undergoing primary PCI.
Larger studies are warranted to assess the prognostic value of fibrinogen over harder end-points. 相似文献
44.
45.
46.
47.
Giovanni Landoni Tiziana Bove Andrea Székely Marco Comis Reitze N. Rodseth Daniela Pasero Martin Ponschab Marta Mucchetti Maria L. Azzolini Fabio Caramelli Gianluca Paternoster Giovanni Pala Luca Cabrini Daniele Amitrano Giovanni Borghi Antonella Capasso Claudia Cariello Anna Carpanese Rinaldo Bellomo 《Journal of cardiothoracic and vascular anesthesia》2013,27(6):1384-1398
48.
49.
Lorenzo Barba MD Federico Paolini Paoletti MD Giovanni Bellomo PhD Lorenzo Gaetani MD PhD Steffen Halbgebauer PhD Patrick Oeckl PhD Markus Otto MD Lucilla Parnetti MD PhD 《Movement disorders》2022,37(4):669-683
The synuclein family includes three neuronal proteins, named α-synuclein, β-synuclein, and γ-synuclein, that have peculiar structural features. α-synuclein is largely known for being a key protein in the pathophysiology of Parkinson's disease (PD) and other synucleinopathies, namely, dementia with Lewy bodies and multisystem atrophy. The role of β-synuclein and γ-synuclein is less well understood in terms of physiological functions and potential contribution to human diseases. α-synuclein has been investigated extensively in both cerebrospinal fluid (CSF) and blood as a potential biomarker for synucleinopathies. Recently, great attention has been also paid to β-synuclein, whose CSF and blood levels seem to reflect synaptic damage and neurodegeneration independent of the presence of synucleinopathy. In this review, we aim to provide an overview on the pathophysiological roles of the synucleins. Because γ-synuclein has been poorly investigated in the field of synucleinopathy and its pathophysiological roles are far from being clear, we focus on the interactions between α-synuclein and β-synuclein in PD. We also discuss the role of α-synuclein and β-synuclein as potential biomarkers to improve the diagnostic characterization of synucleinopathies, thus highlighting their potential application in clinical trials for disease-modifying therapies. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society 相似文献
50.
Golfr Andreasi Nico Romito Luigi Michele Telese Roberta Cilia Roberto Elia Antonio Emanuele Novelli Alessio Tringali Giovanni Messina Giuseppe Levi Vincenzo Devigili Grazia Rinaldo Sara Franzini Angelo Amato Eleopra Roberto 《Neurological sciences》2022,43(3):1769-1781
Neurological Sciences - Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for patients with Parkinson’s disease (PD) with motor complications; the contribution... 相似文献