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81.
Sidharth Totadri Shankar Thipparapu Ritu Aggarwal Madhulika Sharma Shano Naseem Richa Jain 《Pediatric hematology and oncology》2020,37(6):539-544
AbstractImatinib-induced tyrosine kinase inhibition extends beyond the BCR-ABL mutation, resulting in adverse effects. We evaluated hypogammaglobulinemia as a potential ‘off-target’ action of imatinib in children with CML. A cross-sectional, observational study was performed. Patients with CML in chronic phase, age <18-years at diagnosis, receiving imatinib for a duration exceeding 6-months were enrolled. Serum immunoglobulin G, A, and M were measured by end-point nephelometry. Thirty patients were enrolled. The mean age at diagnosis was 10.4?±?3.1?years (range: 5-18). The mean age at enrollment was 16.4?±?4.1?years (range: 9-23). The median dose of imatinib was 287.5?mg/m2 (IQR: 267.3, 345.0). The median duration of imatinib-therapy was 6-years (IQR: 3.0, 10.3). The median (IQR) normalized levels of IgG, IgA, and IgM were 33.0% (IQR: ?12.8, 58.7), 28.1% (IQR: ?17.0, 90.1) and 15.9% (IQR: ?9.3, 40.5), respectively. The IgG, IgA, and IgM levels were reduced in 9 (30%), 8 (27%), and 10 (33%) patients, respectively. Five (17%) patients had pan-hypogammaglobulinemia. We suggest checking immunoglobulin levels in patients with CML receiving imatinib with recurrent/unusual infections. 相似文献
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83.
Adam Mohammad Alan G Dawson Amrita Bajaj Sridhar Rathinam 《Interactive Cardiovascular and Thoracic Surgery》2022,34(4):697
Pure red cell aplasia caused by true thymic hyperplasia is extremely rare. We report the case of a 25-year-old female diagnosed with pure red cell aplasia. Following a thymectomy confirming true thymic hyperplasia and corticosteroid therapy, complete response was achieved. Patients diagnosed with pure red cell aplasia should be investigated with a computerized tomographic scan to assess for thymic pathology and if present, this should be resected. Follow-up is essential to monitor for recurrence. 相似文献
84.
Shahi SK Shukla AC Bajaj AK Banerjee U Rimek D Midgely G Dikshit A 《Skin pharmacology and applied skin physiology》2000,13(1):60-64
Skin disease associated with keratinized tissues in animal and human beings has been investigated. The essential oil of Eucalyptus pauciflora in vitro showed strong antifungal activity at 1.0 microl/ml against human pathogenic fungi, viz. Epidermophyton floccosum, Microsporum audouinii, M. canis, M. gypseum, M. nanum, Trichophyton mentagrophytes, T. rubrum, T. tonsurans and T. violaceum. The oil has heavy doses of inoculum potential at 1.0 microl/ml. Moreover, it did not exhibit any adverse effects on mammalian skin up to 5% concentrations. Further, we formulated the oil in the form of ointment 'BSHT' (broad spectrum herbal therapy) (1% v/v) and subjected it to topical testing on patients attending the outpatient department of M.L.N. Medical College, Allahabad. Fifty patients were selected on the basis of KOH-positive results and diagnosed as either tinea pedis, tinea corporis or tinea cruris. After the second week of treatment, all patients were KOH-negative. At the end of medication, 60% of patients recovered completely and 40% showed significant improvement from the disease. No KOH-negative cases of relapse were observed when patients were re-examined after 2 months following the end of treatment. Thus, the ointment can be exploited commercially after undergoing successful multicenter clinical trials, which are in progress. 相似文献
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Mithila Vanarase Ram Krishan Gautam Pooja Arora Sonali Bajaj Neha Meena Ananta Khurana 《Journal of cosmetic and laser therapy》2017,19(5):259-265
Background: Q-switched lasers are conventionally used for the treatment of black tattoo. However, they require multiple sittings, and the response may be slow due to competing epidermal pigment in dark skin. Objective: To compare the efficacy of Q-switched Nd:YAG laser alone with its combination with ultrapulse CO2 for the removal of black tattoo. Materials and methods: Sixty patients with black tattoo were randomized into two groups viz., group A and group B. Group A was treated with QS Nd:YAG laser (1064 nm) alone, and group B received combination of ablative ultrapulse CO2 followed by fixed-dose QS Nd:YAG laser (1064 nm), at 6-week interval for a maximum of 6 sittings. After each sitting, 3 independent physicians noted percentage of improvement that was evaluated using visual analogue scale (VAS) and grading system for tattoo ink lightening (TIL). Results: Combination laser (group B) showed statistically significant improvement in mean VAS score in the last 2 noted visits as compared to 1st session (p < 0.007, p < 0.001) and TIL mean score in last three noted visits as compared to 1st session (p < 0.008, p < 0.020, and p < 0.004). There was no statistically significant difference in the side effect profile of both the groups. Conclusion: For refractory professional tattoos, combination of ultrapulse CO2 laser and QS Nd:YAG laser is superior to QS Nd:YAG laser alone. 相似文献
88.
Y. Patrice Le Treut M.D. Jean Hardwigsen M.D. Pascal Ananian M.D. Jean Saïsse M.D. Emilie Grégoire M.D. Hubert Richa M.D. Pierre Campan M.D. 《Journal of gastrointestinal surgery》2006,10(6):855-862
Tumor thrombus in major vasculature is a frequent finding with a poor long-term prognosis in patients with hepatocellular
carcinoma (HCC). The utility of surgical resection is still controversial. This study compared morbidity and survival after
resection for HCC with and without tumor thrombus. Data of 108 patients who underwent major hepatic resection for HCC were
prospectively recorded. Patients were divided into two groups. The venous thrombectomy (VT) group included 26 patients who
had HCC with tumor thrombus in the portal or hepatic veins. The matched control group included 82 patients who had HCC without
tumor thrombus. Surgical technique, early outcome, and late survival were analyzed in each group. Multivariate analysis was
performed to assess the prognostic value of this feature. Surgical technique was comparable in the VT and control group with
regard to extent of hepatectomy, procedure duration, and transfusion requirements. Early postoperative outcome was also comparable.
Actuarial survival at 1, 3, and 5 years was 38%, 20%, and 13%, respectively, in the VT group (median: 9 months) versus 74%,
56%, and 33%, respectively, in the control group (median: 41 months). In the subgroup of patients with tumor thrombus limited
to the portal vein, actuarial survival at 1, 3, and 5 years was 50%, 26%, and 17%, respectively, (median: 12 months) and two
patients lived longer than 5 years. Multivariate analysis showed that incomplete resection, alphafetoprotein level greater
than 100 N, more than two tumor nodules, and tumor thrombus in major vasculature were independent factors of poor prognosis.
Survival after resection for HCC with tumor thrombus in the major vasculature is poorer than after resection for HCC without
tumor thrombus. However, an aggressive surgical strategy can provide significant survival with comparable morbidity in selected
cases, that is, tumor thrombus located in the portal vein only and expected complete resection of the lesions. 相似文献
89.
Archana Rastogi Narendra Krishnani Surender Kumar Yachha Vikrant Khanna Ujjal Poddar Richa Lal 《Journal of gastroenterology and hepatology》2009,24(1):97-102
Background and Aim: A major challenge in neonatal cholestasis (NC) is to differentiate biliary atresia (BA) from other non-atretic causes. In developing countries there are considerable problems of late referral of NC cases and performing surgery without prelaparotomy liver biopsy that contributes to a high proportion of negative laparotomy and increased morbidity. We evaluated the hepatic histopathology for presence of features that correlate best with the diagnosis of BA and assessed the accuracy of percutaneous liver biopsy.
Methods: Fifty-five cases of NC that fulfilled the selection criteria and had liver biopsy available were analyzed. Among the 49 adequate liver biopsies, 28 cases were diagnosed as BA, 15 neonatal hepatitis (NH) and 6 were due to other causes. Validity of percutaneous liver biopsy diagnoses was compared with confirmed cases by laparotomy findings and 1-year follow up. Twelve histological parameters of confirmed cases of BA and NH were evaluated by logistic regression analyses.
Results: Ductular proliferation ( P = 0.0002), bile duct and ductular bile plugs ( P = 0.009), and portal fibrosis ( P = 0.002) were the best indicators of BA and among them ductular proliferation was the most important in distinguishing BA from NH. Ductal plate malformation was observed in 17.9% cases of BA. Sensitivity and specificity of percutaneous liver biopsy for diagnosing BA was 88.2% each.
Conclusion: Percutaneous liver biopsy is highly accurate (88.2%) in diagnosing BA. In developing countries. This investigation should be done to decrease the frequency of negative laparotomy and to achieve cost–benefit with reduced morbidity. 相似文献
Methods: Fifty-five cases of NC that fulfilled the selection criteria and had liver biopsy available were analyzed. Among the 49 adequate liver biopsies, 28 cases were diagnosed as BA, 15 neonatal hepatitis (NH) and 6 were due to other causes. Validity of percutaneous liver biopsy diagnoses was compared with confirmed cases by laparotomy findings and 1-year follow up. Twelve histological parameters of confirmed cases of BA and NH were evaluated by logistic regression analyses.
Results: Ductular proliferation ( P = 0.0002), bile duct and ductular bile plugs ( P = 0.009), and portal fibrosis ( P = 0.002) were the best indicators of BA and among them ductular proliferation was the most important in distinguishing BA from NH. Ductal plate malformation was observed in 17.9% cases of BA. Sensitivity and specificity of percutaneous liver biopsy for diagnosing BA was 88.2% each.
Conclusion: Percutaneous liver biopsy is highly accurate (88.2%) in diagnosing BA. In developing countries. This investigation should be done to decrease the frequency of negative laparotomy and to achieve cost–benefit with reduced morbidity. 相似文献
90.