全文获取类型
收费全文 | 7658篇 |
免费 | 384篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 224篇 |
妇产科学 | 205篇 |
基础医学 | 766篇 |
口腔科学 | 208篇 |
临床医学 | 539篇 |
内科学 | 2038篇 |
皮肤病学 | 146篇 |
神经病学 | 534篇 |
特种医学 | 415篇 |
外科学 | 1356篇 |
综合类 | 20篇 |
预防医学 | 252篇 |
眼科学 | 65篇 |
药学 | 346篇 |
中国医学 | 13篇 |
肿瘤学 | 944篇 |
出版年
2024年 | 10篇 |
2023年 | 104篇 |
2022年 | 135篇 |
2021年 | 283篇 |
2020年 | 181篇 |
2019年 | 269篇 |
2018年 | 312篇 |
2017年 | 191篇 |
2016年 | 233篇 |
2015年 | 223篇 |
2014年 | 350篇 |
2013年 | 411篇 |
2012年 | 582篇 |
2011年 | 588篇 |
2010年 | 321篇 |
2009年 | 285篇 |
2008年 | 478篇 |
2007年 | 440篇 |
2006年 | 404篇 |
2005年 | 452篇 |
2004年 | 407篇 |
2003年 | 365篇 |
2002年 | 299篇 |
2001年 | 74篇 |
2000年 | 59篇 |
1999年 | 74篇 |
1998年 | 73篇 |
1997年 | 55篇 |
1996年 | 52篇 |
1995年 | 40篇 |
1994年 | 33篇 |
1993年 | 26篇 |
1992年 | 38篇 |
1991年 | 30篇 |
1990年 | 34篇 |
1989年 | 27篇 |
1988年 | 25篇 |
1987年 | 17篇 |
1986年 | 23篇 |
1985年 | 14篇 |
1984年 | 15篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1973年 | 5篇 |
排序方式: 共有8118条查询结果,搜索用时 15 毫秒
51.
Colleoni M Boni L Calabro F Manente P Nelli P Gaion F Pancheri F Sartori F 《International journal of oncology》1995,6(6):1261-1265
The role of surgical resection remains controversial in malignant pleural mesothelioma. The assessment of its impact on prognosis is complicated by a poor understanding of the prognostic factors in the disease. We therefore evaluated, through univariate and multivariate analysis, the role on prognosis of 24 variables in 57 patients submitted to surgery from 1985 to 1993. Sixteen patients had only exploratory thoracotomy and 12 minimal residual disease after surgery (no nodules >1 cm in diameter). Thirty-four cases had epithelial histotype, 6 sarcomatous and 17 mixed. Median survival for the whole group was 15.7 months. Multivariate analysis showed a highly significant influence on survival for minimal residual disease after surgery (p=0.0006), followed by TNM stage (p=0.01). Median survival for patients with TNM stage I disease was 36.3 months and for patients with minimal residual disease 33 months. In conclusion, these data suggest that patients with limited disease have a longer survival after surgery than those with extensive disease. At the same time, our results indicate that the achievement of significant disease reduction with surgery has a critical impact on the prognosis of pleural mesothelioma. 相似文献
52.
53.
A standardized technique of left laparoscopic hemicolectomy is explained based upon the experience of the authors through the study of 166 cases and other cases described in literature. In the above study all of the single steps and the material needed for this technique, which is one of the most complex in laparoscopic surgery, are explained. 相似文献
54.
BACKGROUND AND AIM: The wide diffusion and increasing use of laparoscopic surgery prompts the authors to broaden discussion to its validity and diagnostic-therapeutic use in emergency abdominal surgery. The aim was to evaluate the efficacy of laparoscopic surgery in the light of reports in the international literature and in relation to the situation in our hospital. METHODS: From April 1994 to May 1998, out of 1016 emergency abdominal operations performed at our hospital, 783 (77.5%) used a laparoscopic approach for diagnostic and therapeutic purposes: intestinal occlusion: 26 cases; gastrointestinal ulcer pathology: 15 cases; hepatobiliary pathology: 398 cases; "pelvic" pathology: 305 cases; colic pathology: 39 cases. These represent 24.4% of all laparoscopic procedures carried out during the same period. We preferred to use immediate laparotomic access in patients with the following characteristics: anamnesis of previous surgery for malignant pathologies; anamnesis of more than two major abdominal operations; massive intestinal distension; patients whose general conditions were a contraindication to a laparoscopic approach. RESULTS: The conversion rate was 6.2% (49 cases) with morbidity of 3.4% (25 cases) and a mortality rate of 0.2% (2 cases). A final diagnosis was made in 763 patients (97.4%) with the possibility of treating 719 of them (94.2%), again using a laparoscopic approach. CONCLUSIONS: It is right to regard the laparoscopic approach in emergency abdominal surgery as a feasible and safe model, offering a high potential for diagnosis and therapy if appropriately performed by an expert and well coordinated team. The increased experience of mini-invasive surgery and the improved range of instruments available make the laparoscopic approach a valid alternative to laparotomy, even in the event of emergency abdominal pathologies. 相似文献
55.
Nielsen I Sartori S Tassinari D Pennacchio G Calia N Malacarne P 《International journal of oncology》1992,1(7):791-794
Carboplatin-induced changes in plasma iron levels and the related erythropoiesis impairment were investigated in 32 neoplastic patients for a total of 64 courses of chemotherapy. Iron showed a significant increase over pretreatment levels starting from day 1 after carboplatin administration (p< 0.001). Return to pre-treatment levels was achieved on day 14. Hemoglobin decreased significantly on day 7 (p< 0.05) and further on days 14 and 21 (p< 0.001). In patients undergoing 3 consecutive cycles of chemotherapy, basal hemoglobin before the 2nd cycle was significantly lower than before the 1st (p< 0.05), whereas before the 3rd cycle the levels were similar to those before the 2nd. Hemoglobin time-course did not differ among the three cycles. No relationship was observed between maximum iron levels and hemoglobin at minimum levels, nor between pre-treatment hemoglobin levels and severity of chemotherapy-induced subacute anemia. These results suggest that neither pre-treatment hemoglobin nor the entity of iron increase are predictive of the need of blood transfusion. Moreover, the absence of correlation between iron increase and hemoglobin decrease suggests that the toxic block on erythroid maturation is not the only mechanism with which platinum compounds interfere with iron metabolism. It is possible that the bivalent platinum ion may displace competitively iron from its binding sites, either on proteins or on cells. 相似文献
56.
Salvatore Restivo MD Riccardo Speciale MD Rosalia Gargano MD Riccardo Di Leo MD Francesco Farinella MD Salvatore Gallina MD 《Operative Techniques in Otolaryngology》2003,14(2):153-156
During the last 20 years, various conservative surgical techniques have been proposed to treat larynx cancer. On the basis of our various experiences and of the ultrastructural data on the tissues treated with radiowaves, we decided to also use radiosurgery in operations under direct microlaryngoscopy. We select 18 patients suffering from epidermoid carcinoma. These patients had been referred to our ENT clinic at the Polichnico of Palermo between 1999 and 2001. The authors describe the surgical procedures used and emphasize the advantages of radiosurgery in the treatment of larynx cancer. 相似文献
57.
58.
59.
60.
Tiziano Maggino M.D. Cesare Romagnolo M.D. Fabio Landoni M.D. Enrico Sartori M.D. Paolo Zola M.D. Angiolo Gadducci M.D. 《Gynecologic oncology》1998,68(3):274-279
Objective.The aim of this study was to define the clinical–therapeutical approach to endometrial cancer now being followed in some of the most important centers of reference for gynecological cancer in North America by means of a questionnaire.Study design.The questionnaire focused on four principal areas: (1) surgical staging and therapy; (2) adjuvant treatment; (3) treatment modifications; and (4) management of advanced stages (FIGO III–IV).Results.There were 48 evaluable responses (77%) received by the end of December 1994 which were considered for this analysis. Lymphadenectomy is utilized routinely in 26/48 centers (54.2%) and in selective clinical–pathological conditions in another 21/48 centers (43.5%). In the majority of centers (31/48; 64.6%) radical surgery is utilized for selected indications such as cervical involvement. Only 3/48 (6.2%) centers consider the vaginal approach totally inappropriate. The great majority (40/48; 83.3%) of the centers considered postsurgical adjuvant therapy to be necessary in FIGO Stage Ic. Brachytherapy is routinely performed in 3 centers (6.2%) in postsurgical management of Stage I endometrial cancer, while the majority of the centers (31/48; 64.6%) perform brachytherapy of the vaginal vault in certain clinical–pathological conditions. A wide variety of treatments are used for advanced stages (FIGO III–IV).Conclusions.It emerges that some controversial aspects exist on endometrial cancer treatment, and these conflicting data need a large-scale multicenter randomized clinical trial. 相似文献