全文获取类型
收费全文 | 3287篇 |
免费 | 189篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 107篇 |
妇产科学 | 74篇 |
基础医学 | 368篇 |
口腔科学 | 20篇 |
临床医学 | 516篇 |
内科学 | 620篇 |
皮肤病学 | 52篇 |
神经病学 | 321篇 |
特种医学 | 57篇 |
外科学 | 284篇 |
综合类 | 27篇 |
一般理论 | 5篇 |
预防医学 | 459篇 |
眼科学 | 39篇 |
药学 | 229篇 |
中国医学 | 2篇 |
肿瘤学 | 284篇 |
出版年
2024年 | 6篇 |
2023年 | 26篇 |
2022年 | 29篇 |
2021年 | 112篇 |
2020年 | 73篇 |
2019年 | 84篇 |
2018年 | 108篇 |
2017年 | 81篇 |
2016年 | 75篇 |
2015年 | 65篇 |
2014年 | 117篇 |
2013年 | 192篇 |
2012年 | 272篇 |
2011年 | 279篇 |
2010年 | 147篇 |
2009年 | 121篇 |
2008年 | 241篇 |
2007年 | 223篇 |
2006年 | 216篇 |
2005年 | 209篇 |
2004年 | 197篇 |
2003年 | 194篇 |
2002年 | 167篇 |
2001年 | 22篇 |
2000年 | 12篇 |
1999年 | 17篇 |
1998年 | 31篇 |
1997年 | 28篇 |
1996年 | 18篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 12篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 10篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1977年 | 2篇 |
1965年 | 1篇 |
1962年 | 1篇 |
1955年 | 1篇 |
1925年 | 1篇 |
排序方式: 共有3485条查询结果,搜索用时 0 毫秒
21.
Andrea Cuviello Renee Boss Nirali Shah Haven Battles Andrea Beri Lori Wiener 《Pediatric blood & cancer》2019,66(8)
Pediatric phase I clinical oncology trials represent a unique cohort of patients who have not responded to standard therapies and remain highly vulnerable to treatment toxicity and/or disease burden. Incorporating a palliative care consultation into the care plan for those with relapsed/refractory cancer where chance of cure is limited is generally recommended. A retrospective chart review of pediatric phase I trials revealed that palliative care was consulted in <20% of patients, most often for symptom management. Efforts to increase the use of palliative services in this population may enhance quality of life for children and families enrolled in phase I studies. 相似文献
22.
23.
Castillo Renee Chan Alissa Atallah Steven Derry Katrina Baje Mark Zimmermann Lara L. Martin Ryan Groysman Leonid Stern‑Nezer Sara Minokadeh Anush Nova Alan Huang WanTing Cang William Schomer Kendra 《Journal of thrombosis and thrombolysis》2021,51(1):246-246
Journal of Thrombosis and Thrombolysis - In the original publication of the article, unfortunately the given name and family name of the author’s in the author group were inadvertently... 相似文献
24.
Cheryl Clarke Renee K. Sedlacek Susan B. Watson 《American journal of pharmaceutical education》2016,80(2)
Objective. To evaluate the impact of a simulation on pharmacy student attitudes toward poverty using the Attitude toward Poverty (ATP) Short Form scale.Methods. Second-year pharmacy students participated in the 3-hour Missouri Association for Community Action Poverty Simulation. Students completed a survey of the ATP Short Form scale prior to and following participation in the simulation.Results. Significant improvements in attitude were noted in 15 of 21 ATP Short Form items. Improvements in the stigma and structural domains were significant while improvement in the personal deficiency domain was not significant.Conclusions. This poverty simulation exercise positively altered pharmacy student attitudes toward poverty. When combined with didactic and experiential curriculum, this simulation may enhance student achievement of the 2013 Center for the Advancement of Pharmacy Education (CAPE) outcome subdomain of cultural sensitivity. 相似文献
25.
Childhood maltreatment,personality disorders and 3‐year persistence of adult alcohol and nicotine dependence in a national sample 下载免费PDF全文
26.
27.
28.
Fehr C Shirley RL Crabbe JC Belknap JK Buck KJ Phillips TJ 《Alcoholism, clinical and experimental research》2005,29(5):708-720
BACKGROUND: We previously mapped a quantitative trait locus (QTL) for ethanol preference drinking to mouse chromosome 2 (mapped with high confidence, LOD = 15.5, p = 3 x 10(-16)). The specific gene(s) in the QTL interval responsible for phenotypic variation in ethanol preference drinking has not been identified. METHODS: In the current study, we investigated the association of the syntaxin binding protein 1 gene (Stxbp1) with ethanol preference drinking and other ethanol traits using a panel of B6 x D2 (BXD) recombinant inbred (RI) strains derived from the C57BL/6J (B6) and DBA/2J (D2) inbred mouse strains. Confirmation analyses for ethanol consumption and withdrawal were performed using a large B6D2 F2 cross, short-term selected lines derived from the B6 and D2 progenitor strains, and standard inbred strains. RESULTS: BXD RI strain analysis detected provisional associations between Stxbp1 molecular variants and ethanol consumption, as well as severity of acute ethanol withdrawal, ethanol-conditioned taste aversion, and ethanol-induced hypothermia. Confirmation analyses using three independent genetic models supported the involvement of Stxbp1 in ethanol preference drinking but not in ethanol withdrawal. CONCLUSIONS: Stxbp1 encodes a Sec1/Munc18-type protein essential for vesicular neurotransmitter release. The present study provides supporting evidence for the involvement of Stxbp1 in ethanol preference drinking. 相似文献
29.
Bida AT Upshaw Neff JL Dick CJ Schoon RA Brickshawana A Chini CC Billadeau DD 《Molecular immunology》2011,48(9-10):1149-1159
2B4 is a member of the SLAM receptor family capable of activating NK cell cytotoxicity in the context of EBV infection. SAP (SLAM Associated Protein) deficiency causes defective signaling downstream of SLAM family receptors and high susceptibility to EBV. 2B4 costimulates natural cytotoxicity receptor (NCR) and TCR initiated signals to induce cellular cytotoxicity and cytokine release. The 2B4-SAP signal transduction pathway is not predicted to overlap with the TCR-ITAM pathway, although SAP is required for some TCR-induced signals. We therefore examined the functional relationship between SLAM family receptor 2B4 and ITAM-containing adaptor complexes. Removal of Fc?RIγ or CD3ζ-containing complexes, using genetically manipulated cell lines or siRNA specific suppression, significantly reduces 2B4-initiated functions in NK and T cells, respectively. Consistent with this relationship, Syk and ZAP-70 are capable of transducing 2B4 signals for calcium mobilization and cytolysis. Furthermore, ITAM-containing molecules constitutively associate with SAP. These results suggest a potential physical association between 2B4 and the ITAM receptor complexes that is required for 2B4-initiated signaling and cell-mediated killing. 相似文献
30.
Antigen-presenting cells (APC) play a key role in orchestrating immune responses. T-cell proliferative responses are inhibited during the erythrocyte stages of malaria infection, and a number of studies have suggested that APC are responsible for this phenomenon. In the present studies we examine individual components of the T-cell-activating function of APC: expression of costimulatory and major histocompatibility complex (MHC) class II proteins, the ability to process and present antigen to T cells, and the ability to support cytokine production. We find that during the acute phases of Plasmodium yoelii erythrocyte stage infection, APC upregulate the expression of class II MHC and CD80, maintain expression of CD86, process and present antigen, and support gamma interferon production. However the CD11b(+) subpopulation produces a soluble factor or factors that specifically inhibit interleukin-2 (IL-2) production by responding CD4 T cells. This factor is distinct from prostaglandin E(2), NO, or transforming growth factor beta. The data suggest that IL-2 suppression observed during malaria infection is not due to functional defects of APC but is triggered by production of a factor(s) that actively suppresses production of IL-2 by T cells. 相似文献