视网膜电图对玻璃体出血机化和玻璃体手术的意义

报告118例(133眼)由各种疾病引起的玻璃体出血机化患者的视网膜电图(ERG)检查结果,其中31例作了玻璃体手术,结果表明,ERG检查对玻璃体出血机化的患者,能客观地反映其网膜功能,并对玻璃体手术的预后有指导作用。术前ERG检查,a、b波下降越严重,视功能损害显著,术后视力的预后越差,同时证实,玻璃体机化膜是影响a、b波波幅和时间的一个因素。     

N－（4－乙氧苯基）苯甲酰胺类化合物的合成及抗炎、抗变态反应活性研究

Ｎ┐（４┐乙氧苯基）苯甲酰胺类化合物的合成及抗炎、抗变态反应活性研究周玉新１）党永红刘建飞２）徐颖刘百里（沈阳药科大学制药系，沈阳１１００１５）郑文义（东北第六制药厂，沈阳１１００４３）１９８１年，刘百里等〔１，２〕发现和研制的新药益肤酰胺，经药理实...     

拜虫杀和杀飞克对3种卫生害虫的药效报告

本文报道了两种菊酯类卫生杀虫剂，在不同载体表面对３种卫生害虫的触杀试验。结果：（１）拜虫杀在玻璃板面上６．２５ｍｇ／ｍ２时对家蝇速效ＫＴ（５０）为３．３ｍｉｎ；淡色库蚊为４．３ｍｉｎ；持效均达４９天；对德国小蠊ＫＴ（５０）为５．６ｍｉｎ，持效４２天。在木板表面１２．５ｍｇ／ｍ２时，对家蝇速效ＫＴ（５０）为４．３ｍｉｎ，对淡色库蚊为４．６ｍｉｎ，对前者持效４９天，后者４２天。对德国小蠊ＫＴ（５０）为４．９ｍｉｎ，持效３５天。在水泥板面２５ｍｇ／ｍ２时，对家蝇速效ＫＴ（５０）为４／ｍｉｎ，对淡色库蚊为５．０ｍｉｎ，前者持效３５天，后者４２天。对德国小蠊速效ＫＴ（５０）为６．４ｍｉｎ，持效２１天。（２）杀飞克在玻璃面上７．５ｍｇ／ｍ２时，对家蝇速效ＫＴ（５０）为３．７ｍｉｎ，对淡色库蚊为５．１ｍｉｎ，持效均达４９天。在木板面上１５ｍｇ／ｍ２时，对家蝇速效ＫＴ（５０）为４．２ｍｉｎ，对淡色库蚊为６．０ｍｉｎ，对前者持效４９天，后者为４２天。在水泥板面３０ｍｇ／ｍ２时，对家蝇速效Ｋｔ（５０）为４．４ｍｉｎ，对淡色库蚊为５．０ｍｉｎ，对前者持效３５天，后者４２天；对德国小蠊速效ＫＴ（５０）为６．４ｍｉｎ，持效２１天。     

Behavioral aspects of cigarette smoking among industrial college men of Shanghai, China.

A questionnaire survey was conducted among 7,665 students and staff in the factory-operated industrial colleges in Shanghai, China. Response rate was 95.7 per cent. The proportion of smokers among the men was 50.5 per cent; only 0.33 per cent of the women reported they were smokers. Male smokers began smoking upon entering the work force, where social interaction encourages cigarette smoking. Seventy per cent of the male smokers smoked fewer than 10 cigarettes per day. Only 4.3 per cent perceived themselves as very addicted; 3.4 per cent reported they had no confidence in their ability to control the amount they smoke. The Chinese smokers are more likely to succeed in giving up cigarette smoking for at least one day, as well as for longer periods, compared to US smokers. The number of cigarettes smoked may be related to the individual's purchasing power. For China, strategic timeliness in legislative action and education is urgently needed to combat the high prevalence of cigarette smoking in males, at extremely high risk.     

组织多肽特异性抗原在乳腺癌中的临床研究

OBJECTIVE: To investigate the expression of serum tissue polypeptide-specific antigen (TPS) in breast cancer patients and its clinical value in such cases. METHODS: Altogether 160 subjects (90 patients with breast cancer, 40 with benign breast lesions, and 30 healthy subjects) were enrolled in this study. The serum TPS and CA153 levels were measured by ELISA in all the subjects. RESULTS: The levels and positivity rate of serum TPS and CA153 in breast cancer group were significantly higher than those in the normal subjects group and benign lesion group (P<0.01), and became even higher as the malignancy progressed. High serum TPS level was detected in the cancer patients in stage I. Serum TPS level was the most sensitive to bone metastasis of the malignancy, but its highest levels occurred in cases of lymphoid node metastasis (P<0.05). In patients who responded favorably to the treatment, serum TPS and CA153 levels were significantly reduced (P<0.05), but the reduction in TPS levels tended to be more obvious (P<0.05). CONCLUSION: Serum TPS can be used as a very useful and sensitive tumor marker in the diagnosis of breast cancer, especially in case of bone metastasis, and may be of great value in clinical decision-making and assessment of therapeutic effect.     

Effect of inhaled fluticasone propionate on BAL TGF-beta(1) and bFGF concentrations in clinically stable lung transplant recipients.

BACKGROUND: Inhaled fluticasone propionate (FP) therapy decreases inflammation and sub-basement membrane thickness in asthmatic airways. Bronchiolitis obliterans syndrome (BOS) in lung transplant recipients (LTRs) involves progressive airway fibrosis and obliteration. Therefore, augmented immunosuppression may be of some benefit in treating BOS. In this study, we examined the effect of 3 months of treatment with high-dose inhaled FP on the concentrations of 2 fibrogenic factors, transforming growth factor (TGF)-beta(1) and beta fibrogenic growth factor (bFGF) in bronchoalveolar lavage (BAL) fluid from clinically stable LTRs. METHODS: We conducted a randomized, double-blind, placebo-controlled, parallel group study with inhaled FP (750 microg, twice/day for 3 months) in 28 LTRs (15 FP and 13 placebo). We recruited 23 healthy controls. We performed spirometry, bronchoscopy, and bronchoalveolar lavage procedures before treatment and after 3 months of treatment. We used commercially available enzyme-linked immunosorbent assay kits to measure BAL fluid TGF-beta(1) and bFGF concentrations. RESULTS: In LTRs before treatment, BAL TGF-beta(1) concentrations (but not bFGF concentrations), total cell counts, and neutrophil percentage increased compared with controls (p < 0.05). We found no significant differences between FP and placebo groups at baseline measurements. After treatment, BAL TGF-beta(1) concentrations significantly increased in the FP group (p = 0.03), but we found no difference between FP and placebo groups; BAL bFGF concentrations increased during treatment in both groups compared with controls (p < 0.05), but not significantly within either patient group (p > 0.05). We found a reverse correlation between forced expiratory volume in 1 second (FEV(1)) and BAL TGF-beta(1) concentration in the FP group (r = -0.53, p = 0.04), and between FEV(1) and BAL TGF-beta(1) concentration in the placebo group (r = -0.74, p = 0.004). Multivariable analysis indicated no significant independent effects of inhaled FP in either BAL TGF-beta(1) or bFGF concentrations. CONCLUSIONS: Bronchoalveolar fluid TGF-beta(1) concentrations increased in LTRs after transplantation and may correlate with the decrease in lung function. Inhaled FP added to conventional immunosuppression had no effect on TGF-beta(1) or bFGF production in BAL fluid.     

Inhibition on Telomerase Activity and Cytotoxic Effects by Cisplatin in Cultured Human Choroidal Melanoma Cells

Purpose: To study the changes of telomerase activity and cytotoxic effects by Cisplatin; cis-dichlorodiamine platinum (CDDP) in cultured human choroidal melanoma. Material and Methods: The primary cultured human choroidal melanoma cells were cultured in the presence and absence of CDDP with different concentration and time respectively. The toxic effects were evaluated by MTT and the level of telormarse was detected by PCR-ELISA assay. And the relationship between telomerase activity and cytotoxic effects were analyzed by a correlation analysis.Results: Following the increase of the concentration and the time of CDDP, gradually repressed telomerase activity was detected in cultured cells. Meanwhile, the restrain rate of the cells increased. The telomerase activity at 24h and 1μg/ml was repressed significantly compared with the control cells. However, the appearance of cell death lagged behind the decreasing of telomerase.Conclusions: CDDP is an effective telomerase inhibitor in cultured choroidal melan     

北京石景山地区孕妇女婴幼儿血铅动态研究

在严格的质量保证措施下，北京石景山地区２７０名孕妇及其婴儿进行了血铅的追瞎调查。结果显示：孕３月血铅水平为４５．０μｇ／Ｌ，分娩前血铅水平为６４．８μｇ／Ｌ，孕期血铅呈升高趋势，其中后３月升高明显，分娩前血铅约为孕３月血铅的１．５倍；脐带血铅水平为５１．９μｇ／Ｌ，其中有１０．４％的胎儿脐血铅高于１００μｇ／Ｌ；     

膳食纤维分析方法的简化

对ＳｅｌｖｅｎｄｒａｎＲＲ等人的冷中性洗涤剂纤维提取分析法（ＣＮＤＦ）进行简化，改变了各溶剂的处理时间，省去了湿球研磨与超声波处理步骤。将原法中ＳＬＳ－ＰＡＷ－ＤＷＳＯ处理时间１５ｈ，３０ｍｉｎ和１６ｈ分别延长为２２ｈ，４０ｍｉｎ与２２ｈ，化学分析与透射电镜观察结果表明，简化法对膳食纤维的提取分析效果与原推荐法相同，更加方便与实用。     

三吡萘啶对伯氏疟原虫ANKA株超微结构的影响

受染伯氏疟原虫ＡＮＫＡ株小鼠ｉｇ三吡萘啶游离碱１１ｍｇ／ｋｇ给药后１ｈ可见少数滋养体复合物层次增多且断裂，皱缩，并出现间隙，食物泡融合增大，２ｈ后进一步加剧，且疟原虫髓样物也增多，线粒体肿胀，４ｈ后出现变化的原虫更明显增多，８ｈ后绝大多数滋养体结构多已瓦解，仅留上膜残体及大小不等的空泡，总之，其超微结构的变化与咯萘啶作用甚为相似。