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971.
Flávia J. Alencar-Silva Joel O. Barreto Wagner A. Negreiros Paulo G.B. Silva Lívia Maria S. Pinto-Fiamengui Rômulo R. Regis 《The Journal of prosthetic dentistry》2019,121(4):711.e1-711.e6
Statement of problem
Computer-aided design and computer-aided manufacturing (CAD-CAM) has enhanced the physicomechanical stability of ceramics. However, various factors in the oral cavity may impair the longevity of restorations by negatively affecting their properties. Appropriate surface treatments such as glaze application or mechanical polishing are necessary to diminish these effects.Purpose
The purpose of this in vitro study was to evaluate the influence of common beverages and toothbrushing on the surface roughness, microhardness, and color stainability of a vitreous CAD-CAM lithium disilicate ceramic with a glazed or mechanically polished surface.Material and methods
Specimens (N=160) were divided into 2 groups according to the surface treatment method: polishing with abrasive disks or glaze application. Each group was subdivided (n=8) according to the immersion solution and toothbrushing: distilled water and distilled water plus brushing; coffee and coffee plus brushing; black tea and black tea plus brushing; red wine and red wine plus brushing; and cola and cola plus brushing. Before and after simulating a 5-year period of immersion and toothbrushing, a contact profilometer and a Vickers microhardness tester were used to measure the surface roughness and microhardness. CIELab parameters were assessed by using a portable spectrophotometer, and color differences were calculated by using the CIEDE2000 formula (ΔE00). Data were compared by using 3-way ANOVA/Bonferroni test for post hoc analysis (α=.05).Results
Surface roughness increased irrespective of solution (P=.763), being influenced by surface treatment (P<.001), with the glazed groups presenting higher values. Microhardness decrease was influenced by solutions (P<.038) and surface treatment (P<.001), and glazing was associated with lower values. Irrespective of the surface treatment, color stainability was influenced by solutions (P<.001), with ΔE00 values for red wine being above the perceptibility threshold (ΔE00>1.30). No influence of toothbrushing was found for any parameter (P>.05).Conclusions
Despite its excellent mechanical properties, CAD-CAM lithium disilicate ceramic degraded after exposure to commonly consumed beverages. Irrespective of surface treatment, beverages decreased microhardness and caused color changes. Surface roughness increased, showing higher variation for glazed groups. Toothbrushing was unable to potentiate or diminish the observed effects. In general, the results showed that proper mechanical polishing can produce a surface with desirable properties. 相似文献972.
Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. 总被引:2,自引:0,他引:2
Michael J Zuscik Dhruv B Pateder J Edward Puzas Edward M Schwarz Randy N Rosier Regis J O'Keefe 《Journal of orthopaedic research》2002,20(4):811-818
The skeletal system is an important target for lead toxicity. One of the impacts of lead in the skeleton, the inhibition of axial bone development, is likely due to its effect on the normal progression of chondrocyte maturation that is central to the process of endochondral ossification. Since little is known about the effect of lead on chondrocyte function/maturation, its impact on (1) growth factor-induced proliferation, (2) expression of maturation-specific markers type X collagen and BMP-6, and (3) the activity of AP-1 and NF-kappaB was examined in chick growth plate and sternal chondrocyte models. Exposure to lead alone (1-30 microM) resulted in a dose-dependent inhibition of thymidine incorporation in growth plate chondrocytes. Lead also blunted the stimulation of thymidine incorporation by parathyroid hormone-related peptide (PTHrP) and transforming growth factor-beta1 (TGF-beta1), two critical regulators of chondrocyte maturation. Lead (1 and 10 microM), TGF-beta1 (3 ng/ml) and PTHrP (10(-7) M) all significantly inhibited the expression of type X collagen, a marker of chondrocyte terminal differentiation. However, when in combination, lead completely reversed the inhibition of type X collagen by PTHrP and TGF-beta1. The effect of lead on BMP-6. an inducer of terminal differentiation. was also examined. Independently, lead and TGF-beta1 were without effect on BMP-6 expression, but PTHrP significantly suppressed it. Comparatively, lead did not alter PTHrP-mediated suppression of BMP-6, but in combination with TGF-beta1. BMP-6 expression was increased 3-fold. To determine if lead effects on signaling might play a role in facilitating these events, the impact of lead on NF-kappaB and AP-1 signaling was assessed using luciferase reporter constructs in sternal chondrocytes. Lead had no effect on the AP-1 reporter, but it dose-dependently inhibited the NF-kappaB reporter. PTHrP, which signals through AP-1, did not activate the NF-kappaB reporter and did not affect inhibition of this reporter by lead. In contrast, PTHrP activation of the AP-1 reporter was dose-dependently enhanced by lead. These findings, which establish that chondrocytes are important targets for lead toxicity, suggest that the effects of lead on bone growth are derived from its impact on the modulation of chondrocyte maturation by growth factors and second messenger signaling responses. 相似文献
973.
Emily E. Carmody Edward M. Schwarz J. Edward Puzas Randy N. Rosier Regis J. O'Keefe 《Arthritis \u0026amp; Rheumatology》2002,46(5):1298-1308