全文获取类型
收费全文 | 47707篇 |
免费 | 3466篇 |
国内免费 | 197篇 |
专业分类
耳鼻咽喉 | 573篇 |
儿科学 | 1005篇 |
妇产科学 | 971篇 |
基础医学 | 6605篇 |
口腔科学 | 1001篇 |
临床医学 | 4708篇 |
内科学 | 10021篇 |
皮肤病学 | 1077篇 |
神经病学 | 4550篇 |
特种医学 | 1964篇 |
外国民族医学 | 2篇 |
外科学 | 8616篇 |
综合类 | 480篇 |
一般理论 | 76篇 |
预防医学 | 2671篇 |
眼科学 | 938篇 |
药学 | 2795篇 |
中国医学 | 76篇 |
肿瘤学 | 3241篇 |
出版年
2023年 | 468篇 |
2022年 | 920篇 |
2021年 | 1715篇 |
2020年 | 1018篇 |
2019年 | 1347篇 |
2018年 | 1524篇 |
2017年 | 1025篇 |
2016年 | 1201篇 |
2015年 | 1380篇 |
2014年 | 1872篇 |
2013年 | 2182篇 |
2012年 | 3562篇 |
2011年 | 3505篇 |
2010年 | 1947篇 |
2009年 | 1728篇 |
2008年 | 2727篇 |
2007年 | 2783篇 |
2006年 | 2589篇 |
2005年 | 2404篇 |
2004年 | 2228篇 |
2003年 | 2032篇 |
2002年 | 1861篇 |
2001年 | 524篇 |
2000年 | 515篇 |
1999年 | 535篇 |
1998年 | 431篇 |
1997年 | 339篇 |
1996年 | 254篇 |
1995年 | 247篇 |
1994年 | 208篇 |
1993年 | 212篇 |
1992年 | 366篇 |
1991年 | 342篇 |
1990年 | 308篇 |
1989年 | 272篇 |
1988年 | 258篇 |
1987年 | 244篇 |
1986年 | 234篇 |
1985年 | 261篇 |
1984年 | 216篇 |
1983年 | 204篇 |
1982年 | 168篇 |
1981年 | 158篇 |
1980年 | 168篇 |
1979年 | 182篇 |
1978年 | 150篇 |
1977年 | 136篇 |
1976年 | 135篇 |
1974年 | 142篇 |
1973年 | 121篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
23.
24.
Margaret J Bowers Nick J Orr Si Dempsey H Denis Alexander 《Blood coagulation & fibrinolysis》2006,17(5):409-411
We present a case of Bernard Soulier syndrome in a 9-year-old boy caused by a novel genetic mutation. This child was shown to be homozygous for a single nucleotide deletion (c.1077delG) in the GP1BA gene not previously reported. Clinically, the boy has become refractory to platelet transfusions with both allo-antibodies and iso-antibodies and a massive transfusion requirement for ongoing haemorrhage. We describe the critical role that the blood product transfusion continues to play in the management of Bernard Soulier syndrome and discuss therapeutic options in these patients. 相似文献
25.
In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: a pharmacoscintigraphic study in the beagle dog. 总被引:1,自引:0,他引:1
Manish Ghimire Fiona J McInnes David G Watson Alexander B Mullen Howard N E Stevens 《European journal of pharmaceutics and biopharmaceutics》2007,67(2):515-523
The aim of the current study was to investigate the in-vitro and in-vivo performance of a press-coated tablet (PCT) intended for time delayed drug release, consisting of a rapidly disintegrating theophylline core tablet, press-coated with barrier granules containing glyceryl behenate (GB) and low-substituted hydroxypropylcellulose (L-HPC). The PCTs showed pulsatile release with a lag time dependent upon the GB and L-HPC composition of the barrier layer. In-vivo gamma-scintigraphic studies were carried out for PCTs containing GB:L-HPC at 65:35 w/w and 75:25 w/w in the barrier layer in four beagle dogs, in either the fed or fasted state. The in-vivo lag time in both the fed and fasted states did not differ significantly (p>0.05) from the in-vitro lag time. Additionally, no significant difference (p<0.05) between in-vivo fed and fasted disintegration times was observed, demonstrating that in-vivo performance of the PCT was not influenced by the presence or absence of food in the gastrointestinal tract. A distinct lag time was obtained prior to the appearance of drug in plasma and correlated (R2=0.98) with disintegration time observed from scintigraphic images. However, following disintegration, no difference in pharmacokinetic parameters (AUC(0-6 dis), K(el), Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery. 相似文献
26.
Summary Dozens of novel cysteine proteinases have been identified in positive single-stranded RNA viruses and, for the first time, in large double-stranded DNA viruses. The majority of these proteins are distantly related to papain or chymotrypsin and may be direct descendants of primordial proteolytic enzymes. Virus genome synthesis and expression, virion formation, virion entry into the host cell, as well as cellular architecture and functioning can be under the control of viral cysteine proteinases during infection. RNA virus proteinases mediate their liberation from giant multidomain precursors in which they tend to occupy conserved positions. These proteinases possess a narrow substrate specificity, can cleave in cis and in trans, and may also have additional, nonproteolytic functions. The mechanisms of catalysis, substrate recognition and RNA binding were highlighted by the recent analysis of the three-dimensional structure of the chymotrypsin-like cysteine proteinases of two RNA viruses. 相似文献
27.
Fix Joseph A. Alexander Jose Cortese Margot Engle Karen Leppert Paula Repta A. J. 《Pharmaceutical research》1990,7(4):384-387
Short-chain alkyl esters of L-dopa were administered to rats and mice via oral and rectal routes. Plasma L-dopa esters and L-dopa were determined in the systemic and portal circulation by HPLC. A comparison of isopropyl, butyl, and 4-hydroxybutyl esters of L-dopa demonstrated significantly higher levels of the esters in both systemic and portal blood samples following rectal administration than following oral administration. In most cases, oral administration resulted in nondetectable (<0.01 µg/ml) levels of the esters in plasma. Correspondingly, the plasma levels of L-dopa itself were consistently higher following rectal administration. At very high oral doses (500 mg L-dopa equivalents/kg body weight), systemic plasma levels of the butyl ester could be detected (1.25 µg/ml at 10 min), which might indicate saturation of the esterase activity of the small intestine. These studies indicate that the systemic availability of L-dopa from short-chain alkyl esters of L-dopa may be best optimized by rectal administration, which avoids the relatively high esterase activity characteristic of the small intestine. 相似文献
28.
29.
Familial Sneddon's syndrome 总被引:4,自引:0,他引:4
Alexander Lossos Tamir Ben-Hur Ziva Ben-Nariah Claes Enk Moshe Gomori Dov Soffer 《Journal of neurology》1995,242(3):164-168
We report the familial occurrence and apparent autosomal dominant inheritance of Sneddon's syndrome with variable clinical expression. The proband, a 40-year-old woman, presented with livedo reticularis and progressive neurological deterioration following a stroke. The diagnosis was confirmed by cerebral angiogram and skin biopsy, both showing the characteristic findings. Two of the patient's sisters were reported to have been similarly affected in the past. Her mother, two additional siblings and five of her seven children exhibited various vasospastic skin phenomena. Familial aggregation of this disorder may be common and a genetic basis may be involved in its pathogenesis. 相似文献
30.
In his autobiography, Dr. Wilder Penfield relates the medical history of his sister, Mrs. Ruth Inglis, who developed a right frontal oligodendroglioma. Penfield performed the initial craniotomy on her, and after her death, reported the case in a paper on frontal lobe function in humans. Although Penfield has provided more than adequate information on certain aspects of his sister's illness, little has been published concerning her subsequent operation performed by Dr. Harvey Cushing at the Peter Bent Brigham Hospital. We feel this case is significant for several reasons. First, it sheds some light on Penfield's personal relationship with Cushing and his sister; it also shows the deep interest that Dr. Cushing took in his patients. Second, this case nicely illustrates how Cushing used his postoperative drawings to make his operative notes more precise. Finally, we see a sample of the work done by Dr. Louise Eisenhardt as pathologist at the Peter Bent Brigham Hospital. 相似文献