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981.
TJ Mmushi P Masoko LK Mdee MP Mokgotho LJ Mampuru RL Howard 《African journal of traditional, complementary, and alternative medicines》2010,7(1):34-39
Fifteen plant species were collected from the Nelspruit Botanical Garden based on a list of plants provided by Phytomedicine Programme at the University of Pretoria and their ethnopharmacological information. Hexane, dichloromethane (DCM), acetone and methanolic extracts were screened for antimycobacterial activity against Mycobacterium smegmatis. The acetone extract of Milletia stulhimannii was the most active, showing activity against Mycobacterium smegmatis with minimum inhibitory concentration (MIC) value of 0.13 mg/ml. Acetone extracts for all plants had lower MIC values ranging between 0.11–1.25 mg/ml against M. smegmatis. Milletia stulhimannii, Albizia gummifera, Xanthocercis zambesiaca and Barringtonia racemosa have shown great potential as anti-tuberculosis agents. They were active against M. smegmatis with average MIC values of acetone extracts of 0.13 mg/ml. 相似文献
982.
A pilot study of the human chorionic gonadotrophin test for ovarian hyperandrogenism 总被引:1,自引:4,他引:1
A controlled clinical study was designed to investigate the value of human
chorionic gonadotrophin (HCG) challenge as a test for functional ovarian
hyperandrogenism. Dexamethasone administration was followed by 5000 IU HCG
and blood samples for steroid hormone assay were obtained 0, 8, 16, and 24
h thereafter. Study subjects were normal women (n = 13); women with
functional ovarian hyperandrogenism, defined by androgen excess,
amenorrhoea and an increased 17-hydroxyprogesterone response to nafarelin
(n = 6); and normal men (n = 4). The responses of 17-hydroxyprogesterone,
androstenedione and testosterone to HCG in women with functional ovarian
hyperandrogenism were significantly greater than in normal women. However,
the 17-hydroxyprogesterone response to HCG in functional ovarian
hyperandrogenism was significantly lower after HCG than after nafarelin.
The oestradiol response was also significantly lower after HCG than
nafarelin, although oestradiol concentration more than doubled in normal
women as well as in women with functional ovarian hyperandrogenism. The
responses to HCG confirm that functional ovarian hyperandrogenism
abnormalities are luteinizing hormone (LH)-dependent. Therefore, the 17-
hydroxyprogesterone response to HCG could represent a useful test for the
diagnosis of ovarian hyperandrogenism. The lower 17- hydroxyprogesterone
response to HCG than to nafarelin in functional ovarian hyperandrogenism
suggests that a follicle-stimulating hormone (FSH)-responsive factor
modulates thecal 17-hydroxyprogesterone secretion. The oestradiol response
to HCG is consistent with HCG directly stimulating the oestradiol secretion
by thecal cells.
相似文献
983.
Of 101 antegrade pyelography and/or percutaneous nephrostomy procedures performed within a 6-year period, 18 involved patients less than 6 months of age. The procedures in this age group were characterized by ease of performance -without sedation in the neonates and with sedation in the children -and by the use of smaller needles and catheters. The procedures enabled differentiation between obstructed and nonobstructed dilated systems with pressure-flow studies, depiction of the intimate anatomy of complicated urologic abnormalities, temporary drainage, decompression of pyonephrosis, endourologic access, and collection of urine for cultures after ureterosigmoidostomy. The procedures were highly successful and had few complications. 相似文献
984.
Dipanjan Halder Roshan Mathew Nayer Jamshed Sakshi Yadav Brunda RL Praveen Aggarwal Rajiv Narang 《The Journal of emergency medicine》2021,60(4):421-427
BackgroundChest pain is a common presenting symptom in the emergency department (ED). The HEART (history, electroencephalogram [ECG], age, risk factors, and troponin I) score, with addition of troponin at 3 h, helps to determine appropriate risk stratification of the patients.ObjectiveThis study evaluated the utility of the HEART pathway as a decision aid designed for risk stratification of patients with acute-onset chest pain for early and safe disposition.MethodsThis was a prospective observational study done in a tertiary care center. Focused history, 12-lead ECG, and baseline troponin I level on arrival and at hour 3 were recorded. Subjects were classified as low risk (HEART score 0–3) or high risk (HEART score ≥ 4). Patients with a HEART score of 0–3 with negative troponin I at 3 h were discharged and were followed up for major adverse cardiac events (MACEs) within 30 days of ED presentation.ResultsA total of 250 patients were screened for the study, of which 151 were included for the final analysis. One hundred and two patients (68%) were male and 54% of patients were younger than 45 years. HEART scores of 0 (n = 16), 1 (n = 43), 2 (n = 44), and 3 (n = 48) were observed. There was only 1 MACE (0.7%) in 30 days after ED discharge in the study population. The mean length of ED stay in the low-risk group was 4.5 h.ConclusionsLow-risk patients, as per the HEART pathway, can be discharged safely from the ED, which reduces ED stay and health care resource use. 相似文献