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31.
Santosh R. P. Bandlamudi Jimmie L. McGehee Albaraa D. Mando Mohammad Soltani C. Heath Turner James H. Davis Jr Kevin N. West Brooks D. Rabideau 《RSC advances》2021,11(50):31328
Binary mixtures of hydrocarbons and a thermally robust ionic liquid (IL) incorporating a perarylphosphonium-based cation are investigated experimentally and computationally. Experimentally, it is seen that excess toluene added to the IL forms two distinct liquid phases, an “ion-rich” phase of fixed composition and a phase that is nearly pure toluene. Conversely, n-heptane is observed to be essentially immiscible in the neat IL. Molecular dynamics simulations capture both of these behaviours. Furthermore, the simulated composition of the toluene-rich IL phase is within 10% of the experimentally determined composition. Additional simulations are performed on the binary mixtures of the IL and ten other small hydrocarbons having mixed aromatic/aliphatic character. It is found that hydrocarbons with a predominant aliphatic character are largely immiscible with the IL, while those with a predominant aromatic character readily mix with the IL. A detailed analysis of the structure and energetic changes that occur on mixing reveals the nature of the ion-rich phase. The simulations show a bicontinuous phase with hydrocarbon uptake akin to absorption and swelling by a porous absorbent. Aromatic hydrocarbons are driven into the neat IL via dispersion forces with the IL cations and, to a lesser extent, the IL anions. The ion–ion network expands to accommodate the hydrocarbons, yet maintains a core connective structure. At a certain loading, this network becomes stretched to its limit. The energetic penalty associated with breaking the core connective network outweighs the gain from new hydrocarbon–IL interactions, leaving additional hydrocarbons in the neat phase. The spatially alternating charge of the expanded IL network is shown to interact favourably with the stacked aromatic subphase, something not possible for aliphatic hydrocarbons.Binary mixtures of hydrocarbons and a thermally robust ionic liquid (IL) incorporating a perarylphosphonium-based cation are investigated experimentally and computationally. 相似文献
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33.
Sequence analysis of morbillivirus CD150 receptor-signaling lymphocyte activation molecule (SLAM) of different animal species 总被引:1,自引:0,他引:1
J. Sarkar V. Balamurugan A. Sen P. Saravanan B. Sahay K. K. Rajak T. J. Rasool V. Bhanuprakash R. K. Singh 《Virus genes》2009,39(3):335-341
Signaling Lymphocyte Activation Molecule-SLAM (CD150) molecule has been reported as a putative receptor for most morbilliviruses for their respective host
species. In this study, we determined the complete nucleotide sequence of the gene coding for the morbillivirus receptor-SLAM
from the four species, namely, goat (Capra hircus), sheep (Ovis aries), Indian cattle (Bos indicus), and buffalo (Bubalus bubalis). The nucleotide (nt) open reading frame sequence of SLAM gene in all the four species studied was 1017 nucleotides in length
encoding a polypeptide of 339 amino acids (aa), similar to Bos taurus, but different from canine, human, marmoset, and mouse SLAM, which were 1029, 1008, 1011, and 1032 nts, respectively, in
length, and coding for 343, 336, 337, and 344 aa, respectively. Sequence analysis revealed 96.3–98.5% and 92.9–96.8% identities
among the four species at the nt and aa level, respectively. Sequence diversity at aa level between various species revealed
that the critical functional region of SLAM protein among different species is relatively conserved, thereby facilitating
this molecule to act as a receptor for morbillivirus. Phylogenetic relationship based on the aa sequences of SLAM protein
revealed that caprine, ovine, cattle, and buffalo fall under a defined cluster but caprine SLAM is more closely related to
ovine, followed by bovine. 相似文献
34.
35.
Rasool Hemayattalab Leila Rashidi Rostami 《Research in developmental disabilities》2010,31(1):212-217
The purpose of this study was to investigate the effect of frequency of knowledge of results (KR) on the learning of dart in individuals with cerebral palsy type I. Twenty-four individuals with cerebral palsy (CP) between the ages of 5 and 17 were chosen for this study. They were put into 3 homogenous groups according to their records after 20 throws and practiced for 8 sessions. The first group (0% KR) received no KR for any trials, the second group (50% KR) received KR for half of their trials (50%), and the third group (100% KR) received KR for all their trials (100%). The acquisition test was run immediately after the last session and the retention test was run 3 days later.Paired sample t-test and one-way ANOVA were used to analyze the data from the acquisition and retention tests. According to the results of this study, those with cerebral palsy have the ability of acquiring and retaining a new motor skill under the condition of feedback provision. Interestingly it was found that too much feedback interferes with learning of tasks in individuals with CP as in the average population. This finding shows that rules regarding feedback also apply to people afflicted with CP. 相似文献
36.
37.
Background
Pain is said to be one of the most feared and distressing symptoms of cancer and one that disrupts all aspects of life. The purposes of this study were: 1) to compare depression and quality of life among Iranian cancer patients with and without pain; and 2) to determine the relationships between pain beliefs and depression and quality of life. 相似文献38.
Bacterial meningitis in the newborn: a Kuwaiti experience 总被引:1,自引:0,他引:1
Forty-five neonates with bacterial meningitis admitted to a regional hospital in Kuwait over a 5-year period are reported. The attack rate was 6.7/10,000 live births. Listeria monocytogenes was the most common bacteria isolated (31 per cent), followed by Streptococcus agalactiae (15 per cent), and Escherichia coli (11 per cent). Gram negative pathogens constituted 38 per cent of the total. Ten patients died (22 per cent) and 10 (28 per cent of the survivors) developed severe neurological sequelae. 相似文献
39.
Fenton KA Ison C Johnson AP Rudd E Soltani M Martin I Nichols T Livermore DM;GRASP collaboration 《Lancet》2003,361(9372):1867-1869
The Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) monitors trends in antimicrobial resistance in consecutive gonococcal isolates from 26 genitourinary medicine clinics in England and Wales. In 2002, 2204 gonococcal isolates were tested, and the overall prevalence of ciprofloxacin resistance (minimum inhibitory concentration > or =1 mg/L) was 9.8%, compared with 3.1% in 2001 and 2.1% in 2000. Between 2001 and 2002, prevalence of ciprofloxacin resistance increased two to three-fold, irrespective of recent sexual contact overseas, sex, or residence within or outside of London. These findings suggest that national and local treatment guidelines need to be reviewed urgently. 相似文献
40.
T M Calero Moreno G Gustafsson S Garwicz D Grandér G K Jonmundsson B-M Frost A M?kipernaa O Rasool E-R Savolainen K Schmiegelow S S?derh?ll K Vettenranta F Wesenberg S Einhorn M Heyman 《Leukemia》2002,16(10):2037-2045
Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic significance is controversial. DNA from 230 patients was retrospectively analysed by Southern blotting, single strand conformation polymorphism (SSCP) and sequencing techniques. The results were correlated with clinical characteristics and outcome. One hundred and ninety-four fully analysed patients, similarly treated using the Nordic NOPHO-86 or the current NOPHO-92 protocols, were included in the outcome analysis. Deletions approached a minimally deleted region between the p16ink4a and p15ink4b genes, making the p14ARF gene the most commonly deleted coding sequence. Bi-allelic deletion was associated with high white blood cell count (WBC) (P < 0.001), T cell phenotype (P < 0.001) and mediastinal mass (P < 0.001). Patients with Ink4 locus bi-allelic deletions had an inferior pEFS (P < 0.01) and multivariate analysis indicated that bi-allelic deletion of the p16ink4a and the p14ARF genes was an independent prognostic risk factor (P < 0.05). Sub-group analysis revealed a pronounced impact of deletion status for high-risk patients, ie with high WBC. Deletion-status and clinical risk criteria (WBC) could thus be combined to further differentiate risk within the high-risk group. The analysis of the Ink4 locus adds independent prognostic information in childhood ALL treated by Nordic protocols and may help in selection of patients for alternative treatment. 相似文献