全文获取类型
收费全文 | 20048篇 |
免费 | 4985篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 66篇 |
儿科学 | 435篇 |
妇产科学 | 1622篇 |
基础医学 | 346篇 |
口腔科学 | 170篇 |
临床医学 | 15299篇 |
内科学 | 2331篇 |
皮肤病学 | 63篇 |
神经病学 | 806篇 |
特种医学 | 200篇 |
外科学 | 1065篇 |
综合类 | 46篇 |
预防医学 | 1805篇 |
眼科学 | 21篇 |
药学 | 115篇 |
中国医学 | 1篇 |
肿瘤学 | 709篇 |
出版年
2024年 | 75篇 |
2023年 | 777篇 |
2022年 | 105篇 |
2021年 | 252篇 |
2020年 | 628篇 |
2019年 | 222篇 |
2018年 | 1106篇 |
2017年 | 1360篇 |
2016年 | 1439篇 |
2015年 | 1498篇 |
2014年 | 1556篇 |
2013年 | 1817篇 |
2012年 | 513篇 |
2011年 | 763篇 |
2010年 | 1087篇 |
2009年 | 1358篇 |
2008年 | 722篇 |
2007年 | 619篇 |
2006年 | 636篇 |
2005年 | 518篇 |
2004年 | 471篇 |
2003年 | 396篇 |
2002年 | 348篇 |
2001年 | 474篇 |
2000年 | 279篇 |
1999年 | 429篇 |
1998年 | 578篇 |
1997年 | 690篇 |
1996年 | 644篇 |
1995年 | 568篇 |
1994年 | 413篇 |
1993年 | 331篇 |
1992年 | 264篇 |
1991年 | 243篇 |
1990年 | 239篇 |
1989年 | 192篇 |
1988年 | 142篇 |
1987年 | 134篇 |
1986年 | 126篇 |
1985年 | 147篇 |
1984年 | 107篇 |
1983年 | 98篇 |
1982年 | 89篇 |
1981年 | 91篇 |
1980年 | 54篇 |
1979年 | 77篇 |
1978年 | 58篇 |
1977年 | 68篇 |
1976年 | 67篇 |
1972年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Michael R. Jaff DO Mark Bates MD Timothy Sullivan MD Jeffrey Popma MD Xingyu Gao MS Margo Zaugg RN BSN Patrick Verta MS Stat DVM MD 《Catheterization and cardiovascular interventions》2012,80(3):343-350
Background : Atherosclerotic renal artery stenosis (ARAS) causes hypertension (HTN) and threatens renal function (RF). The HERCULES Trial is a prospective, multicenter trial of renal stenting in patients with uncontrolled HTN and ARAS evaluating the safety and effectiveness of the RX Herculink Elite Renal Stent System (Abbott Vascular, Santa Clara, CA). Results : Mean systolic blood pressure (SBP) at baseline was 162 mm Hg. Nearly 70% of patients were receiving three or more antihypertensive medications (mean 3.4 medications per patient). Baseline serum creatinine was 1.2 ± 0.4 and 61.5% of subjects had estimated glomerular filtration <60. The restenosis rate was 10.5% at 9 months. The study device, procedure, and clinical success rates were 96.0, 99.2, and 98.0%, respectively. Freedom from major adverse events was 94.8%. At 9 months, the mean SBP significantly decreased (mean 145, paired t test P < 0.0001) after stenting with no change in medications. There was no correlation between SBP reduction and baseline BNP or BNP reduction. 相似文献
992.
993.
994.
995.
Pamela J. Morgan MD Lisa Cunningham BA Sohini Mitra BSc Natalie Wong BHSc Wei Wu MSc Victoria Noguera RN Mary Li MSc John Semple MD 《Journal canadien d'anesthésie》2013,60(6):528-538
Purpose
In 2007, the World Health Organization created a Surgical Safety Checklist (SSC) that encompassed a simple set of surgical safety standards. The threefold purpose of this study was to add ambulatory-specific items to the SSC, to introduce the items into an ambulatory surgical facility, and to determine if patient outcomes regarding postoperative pain and nausea/vomiting improved following implementation. In addition, safety attitudes, antibiotic timing, regional anesthesia/nerve blocks, preemptive pain medications, prophylactic antiemetics, length of stay, and hospital admission were also assessed.Methods
After Research Ethics Board approval, staff complete a Safety Attitudes Questionnaire. Seven items were added to the SSC. Data were then collected on 180 surgical cases before SSC implementation and 195 cases following implementation. Compliance with each section of the SSC was assessed.Results
On postoperative day one, the median (97.5% confidence interval [CI]) difference between pre- and post-implementation pain scores was 0.5 (97.5% CI, 0 to 1; P = 0.13), and the median difference in the rate of post-discharge nausea/vomiting was ?8.4% (97.5% CI, ?17.9 to 1.1; P = 0.06). There was no improvement in safety attitudes or any of the secondary outcomes, with the exception of the use of preemptive pain medications. Compliance with the three sections of the checklist, i.e., BRIEFING, TIME OUT, and DEBRIEFING was 99.49%, 97.95%, and 96.92%, respectively. There was low compliance in verbalization of the added “ambulatory-specific items”.Conclusion
Potential reasons for lack of uptake and integration include poor “user” buy-in, an overly lengthy checklist, and lack of prioritization of ambulatory-specific items. A shortened SSC was developed based on the results of this study. This trial was registered at ClinicalTrials.gov ID: NCT00934310. 相似文献996.
Fleur E. Brölmann MD Anne M. Eskes MSc PhD Bauer E. Sumpio MD PhD Dieter O. Mayer MD Zena Moore RGN PhD Magnus S. Ågren DMSci Michel Hermans MD Keith Cutting MSc RN Dink A. Legemate MD PhD Hester Vermeulen RN PhD Dirk T. Ubbink MD PhD 《Wound repair and regeneration》2013,21(5):641-647
In wound care research, available high‐level evidence according to the evidence pyramid is rare, and is threatened by a poor study design and reporting. Without comprehensive and transparent reporting, readers will not be able to assess the strengths and limitations of the research performed. Randomized clinical trials (RCTs) are universally acknowledged as the study design of choice for comparing treatment effects. To give high‐level evidence the appreciation it deserves in wound care, we propose a step‐by‐step reporting standard for comprehensive and transparent reporting of RCTs in wound care. Critical reporting issues (e.g., wound care terminology, blinding, predefined outcome measures, and a priori sample size calculation) and wound‐specific barriers (e.g., large diversity of etiologies and comorbidities of patients with wounds) that may prevent uniform implementation of reporting standards in wound care research are addressed in this article. The proposed reporting standards can be used as guidance for authors who write their RCT, as well as for peer reviewers of journals. Endorsement and application of these reporting standards may help achieve a higher standard of evidence and allow meta‐analysis of reported wound care data. The ultimate goal is to help wound care professionals make better decisions for their patients in clinical practice. 相似文献
997.
Takeo Minematsu PhD Gojiro Nakagami PhD Yuko Yamamoto MHS Toshiki Kanazawa BBA Lijuan Huang PhD Hiroe Koyanagi MHS Sanae Sasaki RN Gentaro Uchida PhD Hideki Fujita PhD Nobuhiko Haga PhD Kotaro Yoshimura PhD Takashi Nagase PhD Hiromi Sanada PhD 《Wound repair and regeneration》2013,21(2):329-334
Because wound exudate includes secreted proteins that affect wound healing, its biochemical analysis is useful for objective assessment of chronic wounds. Wound blotting allows for collection of fresh exudate by attaching a nitrocellulose membrane onto the wound surface. To determine its applicability for several analysis methods and its executability in clinical wound assessment, this study comprised an animal experiment and clinical case reports. In the animal experiment, full‐thickness wounds were created on the dorsal skin of mice, and exudate samples were collected daily by a conventional method and by wound blotting. Extremely small but adequate volumes of exudate were collected by wound blotting for subsequent analysis in the animal experiments. Immunostaining showed the concentration and distribution of tumor necrosis factor (TNF) α. The activity of alkaline phosphatase was visualized by reaction with chemiluminescent substrate. The TNF distribution analysis indicated three different patterns: wound edge distribution, wound bed distribution, and a mostly negative pattern in both the animal and clinical studies, suggesting association between the TNF distribution pattern and wound healing. Our results indicate that wound blotting is a convenient method for biochemical analysis of exudate and a candidate tool with which to predict the healing/deterioration of chronic ulcers. 相似文献
998.
Shinji Iizaka RN PhD Toshiko Kaitani RN PhD Junko Sugama RN PhD Gojiro Nakagami RN PhD Ayumi Naito RN MHS Hiroe Koyanagi RN MHS Chizuko Konya RN PhD Hiromi Sanada RN PhD 《Wound repair and regeneration》2013,21(1):25-34
This multicenter prospective cohort study examined the predictive validity of granulation tissue color evaluated by digital image analysis for deep pressure ulcer healing. Ninety‐one patients with deep pressure ulcers were followed for 3 weeks. From a wound photograph taken at baseline, an image representing the granulation red index (GRI) was processed in which a redder color represented higher values. We calculated the average GRI over granulation tissue and the proportion of pixels exceeding the threshold intensity of 80 for the granulation tissue surface (%GRI80) and wound surface (%wound red index 80). In the receiver operating characteristics curve analysis, most GRI parameters had adequate discriminative values for both improvement of the DESIGN‐R total score and wound closure. Ulcers were categorized by the obtained cutoff points of the average GRI (≤80, >80), %GRI80 (≤55, >55–80, >80%), and %wound red index 80 (≤25, >25–50, >50%). In the linear mixed model, higher classes for all GRI parameters showed significantly greater relative improvement in overall wound severity during the 3 weeks after adjustment for patient characteristics and wound locations. Assessment of granulation tissue color by digital image analysis will be useful as an objective monitoring tool for granulation tissue quality or surrogate outcomes of pressure ulcer healing. 相似文献
999.
1000.