Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral leishmaniasis in Bangladesh

Annual leishmanin skin test (LST) surveys were conducted in a visceral leishmaniasis-endemic Bangladeshi community from 2002 through 2004, using Leishmania infantum antigen from the same manufacturer and batch. In 2002, 530 (35%) of 1,532 had positive LST results; the prevalence increased with increasing age. The LST result was positive in 24 (51%) of 47, 18 (72%) of 25, and 11 (85%) of 13 kala-azar patients treated in the previous 1-11, 12-23, and 24-35 months. A positive LST result in 2002 was associated with protection against subsequent kala-azar (P < 0.0001). In 2003-2004, decreased antigen sensitivity was observed. Among 686 participants, 34% were LST-positive in 2002, 29% in 2003, and 19% in 2004. Of 63 cured kala-azar patients, 70% were positive in 2002, 53% in 2003, and only 30% in 2004. Among 171 participants tested with both antigens, L. infantum study antigen sensitivity was 70% compared with L. amazonensis antigen. Our data underscore the need for better production, standardization, and documentation of sensitivity, potency, and stability of leishmanin antigens.     

Using GIS and Secondary Data to Target Diabetes-Related Public Health Efforts

Objectives

To efficiently help communities prevent and manage diabetes, health departments need to be able to target populations with high risk but low resources. To aid in this process, we mapped county-level diabetes-related rates and resources/use using publicly available secondary data to identify Michigan counties with high diabetes prevalence and low or no medical and/or community resources.

Methods

We collected county-level diabetes-related rates and resources from Web-based sources and mapped them using geographic information systems (GIS) software. Data included age-adjusted county diabetes rates, diabetes-related medical resource and resource use (i.e., the number of endocrinologists and percentage of Medicare patients with diabetes who received hemoglobin A1c testing in the past year), community resources (i.e., the number of certified diabetes self-management education and diabetes support groups), as well as population estimates and demographics (e.g., rural residence, education, poverty, and race/ethnicity). We created GIS maps highlighting areas that had higher-than-median rates of disease and lower-than-median resources. We also conducted linear, logistic, and Poisson regression analyses to confirm GIS findings.

Results

There were clear regional trends in resource distribution across Michigan. The 15 counties in the Upper Peninsula were lacking in medical resources but higher in community resources compared with the 68 counties in the Lower Peninsula. There was little apparent association between need (diabetes prevalence) and diabetes-related resources/use. Specific counties with high diabetes prevalence and low resources were easily identified using GIS mapping.

Conclusion

Using public data and mapping tools identified diabetes health-service shortage areas for targeted public health programming.Diabetes is endemic in the United States and its prevalence is increasing. From 2004 to 2010, the age-adjusted rate of diabetes among adults rose from 7.3% to 8.4%, and annual incidence rates continue to rise.^1,2 Type 2 diabetes accounts for approximately 95% of diabetes cases,³ and this increased prevalence has been attributed primarily to lifestyle changes and the increasing rates of obesity in the U.S.^4–6Diabetes is a chronic condition that involves a considerable amount of medical care as well as careful disease self-management.⁷ In addition to regularly scheduled primary care visits and endocrinology visits for complicated cases,⁸ those with diabetes must adhere to appropriate self-management practices, including glucose monitoring; foot self-examinations; and regimens for nutrition, exercise, and prescribed medications.^9,10 These lifestyle changes can be confusing, especially regarding nutrition, and adherence is difficult.^11,12 However, public health strategies, such as individual and group health education within clinic and community settings, have proven effective in facilitating these changes.^13–16 As a result, diabetes self-management education (DSME) programs are recommended by the American Diabetes Association (ADA) for all people diagnosed with diabetes.^17,18 Diabetes support groups have also emerged as a popular community resource for diabetes management.¹⁹Unfortunately, demand for these services is rising at a time that public health budgets are shrinking.^20,21 In the face of limited public health funds, developing strategies to accurately target services is crucial. Historically, public health data have played a key role, frequently through large-scale surveillance efforts and longitudinal survey studies.^22,23 However, the expense of collecting these data places them outside the reach of most state and local public health efforts. The increased availability of electronically, publicly accessible health-related information^24,25 can allow state and local systems to more efficiently target diabetes programming.²⁶ This study describes one such method that was conducted using county-level Michigan data coupled with geographic information systems (GIS), a powerful tool for identifying and communicating problem areas. The purpose of this study was to demonstrate the utility of secondary data analysis and GIS in determining if diabetes rates were associated with diabetes-related resources and resource use, as well as to identify diabetes-related high need/low resource counties within Michigan.     

Postcoital intra-uterine aspirate--a unique criterion for selecting patients for natural or assisted conception

The success of any infertility management programme is reflected in its efficacy to achieve a pregnancy either spontaneously or through assistance. For this purpose some routine investigations are carried out to pinpoint the nature of problem(s) which an infertile couple is troubled with. As the basic requisite for conception to occur is the accumulation of motile spermatozoa around the egg at the site of fertilisation, proper assessment of sperm transit from the vagina to the tubal ampulla becomes a very important criterion to predict the possibility of spontaneous pregnancy. Till date postcoital test was the sole investigative tool available to serve this purpose but unfortunately it fails to furnish any information about the concentration and nature of quality of spermatozoa beyond the cervix. This results in the disparity between postcoital test results and pregnancy outcome. In the present study intra-uterine fluid was examined along with cervical mucus 4-6 hours postcoitus in the pre-ovulatory period. The objective was to gather information about the fate of spermatozoa subjected to the uterine environment after being vaginally deposited during coitus. The result of this combined test has been found to be very much informative and helpful for the fertility physician to set the criteria for timed intercourse and / or intra-uterine insemination. This simple test thus appears to play a leading role in infertility management in near feature.     

Programmatic Approaches for Nutritional Care in India: Addressing the Continuum of Care Perspectives

Child health and nutrition is nested within a larger gamut of child care and development, functioning through the health care system. Malnutrition is multidimensional and rooted in poor early childhood care and development that is shaped by environmental, social and economic factors. Current nutrition care interventions are marked by a piecemeal approach, focusing on treating malnutrition but overlooking the need for rehabilitation and care support. Continuum of care (CoC) as an approach aims for a seamless and need-based care, bearing an impact on improved care output, beneficiary participation, care experience and access to care. CoC in nutrition care shall contribute to integration of nutrition and health care services, addressing distal and proximal causes of undernutrition through a gamut of preventive, promotive, treatment and rehabilitative care.     

Screening for SAM in the community: Is MUAC a ‘Simple Tool’?

Anthropometric data from our survey of 1,879 children in Madhya Pradesh revealed low sensitivity (17.5%) and positive predictive value (30.4%) of Mid-Upper Arm Circumference (MUAC) at the recommended cut-off of 115 mm for identifying Severe Acute Malnutrition (SAM). This led us to question the reliability of MUAC as a screening tool to identify SAM at the community level, especially in the context of very high levels of stunting.     

Rapid survey of wasting and stunting in children: What’s new,what’s old and what’s the buzz?

Nationwide Rapid Survey on Children (RSoC), conducted by the Ministry of Women and Child Development and UNICEF in 2013-14 showed a marked improvement in the status of the child malnutrition over the third National Family Health Survey (NFHS-3) that was conducted in 2005-06. Despite some impressive gains in the anthropometric indicators of malnutrition, the absolute levels remain high, and of concern. Despite these gains, the feeding indicators remain stagnant. The programmatic responses need to adopt a multi-sectoral comprehensive approach with regular and comprehensive nutrition surveillance and recognize the epidemiological diversity.     

Giant mucinous cystic neoplasms of pancreas and liver with unusual adipose tissue component: a case report

Simultaneous occurrence of pancreatic and hepatic mucinous cystic neoplasms is very rarely reported in the literature. We present a case with extensive fatty component of the pancreatic tumour arising from the head of the pancreas and attaining a huge size before being treated by Whipple’s pancreatoduodenectomy and subsequently by a right hepatectomy for the hepatic tumour.Key Words: Pancreas, mucinous cystic neoplasm, giant, cystadenoma, whipple’s pancreatoduodenectomy, liver, hepatectomy, adipose     

Timing of first sex before marriage and its correlates: evidence from India

While several studies have documented the extent of pre-marital sexual experience among young people in India, little work has been done to explore the factors that are correlated with the timing of pre-marital sexual initiation. This paper examines age at initiation of pre-marital sex, circumstances in which first sex was experienced, nature of first sexual experience and correlates of age at initiation of pre-marital sex. Life table estimates suggest that pre-marital sexual initiation occurred in adolescence for 1 in 20 young women and 1 in 10 young men. For the majority of these young people, their first sex was with an opposite-sex romantic partner. First sex, moreover, was unprotected for the majority and forced for sizeable proportion of young women. A number of individual, family-, peer- and community-level factors were correlated with age at first pre-marital sex. Moreover, considerable gender differences were apparent in the correlates of age at first pre-marital sex, with peer- and parent-level factors found more often to be significant for young women than men.