全文获取类型
收费全文 | 2495篇 |
免费 | 221篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 57篇 |
妇产科学 | 18篇 |
基础医学 | 435篇 |
口腔科学 | 24篇 |
临床医学 | 347篇 |
内科学 | 494篇 |
皮肤病学 | 121篇 |
神经病学 | 192篇 |
特种医学 | 70篇 |
外科学 | 282篇 |
综合类 | 23篇 |
一般理论 | 1篇 |
预防医学 | 172篇 |
眼科学 | 34篇 |
药学 | 230篇 |
中国医学 | 18篇 |
肿瘤学 | 185篇 |
出版年
2023年 | 33篇 |
2022年 | 98篇 |
2021年 | 169篇 |
2020年 | 100篇 |
2019年 | 96篇 |
2018年 | 94篇 |
2017年 | 73篇 |
2016年 | 72篇 |
2015年 | 78篇 |
2014年 | 98篇 |
2013年 | 111篇 |
2012年 | 176篇 |
2011年 | 172篇 |
2010年 | 116篇 |
2009年 | 80篇 |
2008年 | 124篇 |
2007年 | 143篇 |
2006年 | 132篇 |
2005年 | 110篇 |
2004年 | 97篇 |
2003年 | 94篇 |
2002年 | 83篇 |
2001年 | 66篇 |
2000年 | 43篇 |
1999年 | 42篇 |
1998年 | 20篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 7篇 |
1994年 | 12篇 |
1993年 | 8篇 |
1992年 | 11篇 |
1991年 | 11篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 10篇 |
1987年 | 16篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 6篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1968年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有2721条查询结果,搜索用时 15 毫秒
51.
Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis 总被引:5,自引:0,他引:5
Thwaites GE Lan NT Dung NH Quy HT Oanh DT Thoa NT Hien NQ Thuc NT Hai NN Bang ND Lan NN Duc NH Tuan VN Hiep CH Chau TT Mai PP Dung NT Stepniewska K White NJ Hien TT Farrar JJ 《The Journal of infectious diseases》2005,192(1):79-88
BACKGROUND: Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain. METHODS: We performed a prospective study of 180 Vietnamese adults admitted consecutively for TBM. M. tuberculosis was cultured from the cerebrospinal fluid (CSF) of all patients and was tested for susceptibility to first-line antituberculosis drugs. Presenting clinical features, time to CSF bacterial clearance, clinical response to treatment, and 9-month morbidity and mortality were compared between adults infected with susceptible and those infected with drug-resistant organisms. RESULTS: Of 180 isolates, 72 (40.0%) were resistant to at least 1 antituberculosis drug, and 10 (5.6%) were resistant to at least isoniazid and rifampicin. Isoniazid and/or streptomycin resistance was associated with slower CSF bacterial clearance but not with any differences in clinical response or outcome. Combined isoniazid and rifampicin resistance was strongly predictive of death (relative risk of death, 11.63 [95% confidence interval, 5.21-26.32]) and was independently associated with human immunodeficiency virus infection. CONCLUSIONS: Isoniazid and/or streptomycin resistance probably has no detrimental effect on the outcome of TBM when patients are treated with first-line antituberculosis drugs, but combined isoniazid and rifampicin resistance is strongly predictive of death. 相似文献
52.
53.
54.
Stacey L. Gorniak Aisha Khan Nereyda Ochoa Morali D. Sharma Cecile L. Phan 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2014,232(4):1283-1291
Although evidence has emerged regarding functional neural impairment of all four limbs with a diagnosis of type II diabetes (T2D), there is conflicting evidence regarding impairment in manual function with the disease. The purpose of the current study was to evaluate hand/fingertip function in T2D as compared to healthy age- and gender-matched controls. Ten adults with T2D and ten healthy age- and gender-matched control subjects underwent a battery of clinically validated and laboratory-based evaluations of sensory function, motor function, and quality of life evaluation. The T2D group exhibited sensory dysfunction and altered kinetic output and inconsistent differences in clinically-validated timed performance tasks as compared to age-matched controls. No difference in quality of life was found between the two groups. Sensory dysfunction and some timed evaluations correlated with disease severity. Linear kinetic features did not covary with diminished sensation; however, nonlinear measures did covary with sensation changes. None of the recorded measures were related to clinical diagnosis of peripheral neuropathy. The relationship among exhibited behavioral changes is discussed in terms of small fiber neuropathy, micro-vascular adaptations, and endothelial dysfunction co-occurring with T2D. 相似文献
55.
56.
57.
Valérie Biran An Phan Duy Fabrice Decobert Nathalie Bednarek Corinne Alberti Olivier Baud 《Developmental medicine and child neurology》2014,56(8):717-723
The prevention of neurological disabilities following preterm birth remains a major public health challenge and efforts are still needed to test the neuroprotective properties of candidate molecules. Melatonin serves as a neuroprotectant in adult models of cerebral ischemia through its potent antioxidant and anti‐inflammatory effects. An increasing number of preclinical studies have consistently demonstrated that melatonin protects the damaged developing brain by preventing abnormal myelination and an inflammatory glial reaction, a major cause of white matter injury. The main questions asked in this review are whether preclinical data on the neuroprotective properties of melatonin are sufficient to translate this concept into the clinical setting, and whether melatonin can reduce white matter damage in preterm infants. This review provides support for our view that melatonin is now ready to be tested in human preterm neonates, and discusses ongoing and planned clinical trials. 相似文献
58.
59.
Schwartz BG Kloner RA Thomas JL Bui Q Mayeda GS Burstein S Hale SL Economides C French WJ 《The American journal of cardiology》2012,110(3):461-466
This report focuses on cardioprotection and describes the advantages and disadvantages of various methods of inducing therapeutic hypothermia (TH) with regard to neuroprotection and cardioprotection for patients with cardiac arrest and ST-segment elevation myocardial infarction (STEMI). TH is recommended in cardiac arrest guidelines. For patients resuscitated after out-of-hospital cardiac arrest, improvements in survival and neurologic outcomes were observed with relatively slow induction of TH. More rapid induction of TH in patients with cardiac arrest might have a mild to modest incremental impact on neurologic outcomes. TH drastically reduces infarct size in animal models, but achievement of target temperature before reperfusion is essential. Rapid initiation of TH in patients with STEMI is challenging but attainable, and marked infarct size reductions are possible. To induce TH, a variety of devices have recently been developed that require additional study. Of particular interest is transcoronary induction of TH using a catheter or wire lumen, which enables hypothermic reperfusion in the absence of total-body hypothermia. At present, the main methods of inducing and maintaining TH are surface cooling, endovascular heat-exchange catheters, and intravenous infusion of cold fluids. Surface cooling or endovascular catheters may be sufficient for induction of TH in patients resuscitated after out-of-hospital cardiac arrest. For patients with STEMI, intravenous infusion of cold fluids achieves target temperature very rapidly but might worsen left ventricular function. More widespread use of TH would improve survival and quality of life for patients with out-of-hospital cardiac arrest; larger studies with more rapid induction of TH are needed in the STEMI population. 相似文献
60.