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71.
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粮谷尘致肺损害的实验研究 总被引:2,自引:1,他引:1
粮谷尘为混合性粉尘,含游离SiO29.77%,分离培养出普通高温放线菌。染尘动物肺脏早期病变主要为小灶性肺泡炎、灶性间质性肺炎、异物肉芽肿等,大、中支气管壁脱颗粒肥大细胞增多。90d以后,上述病变明显减少,但逐渐出现少数小的细胞结节,间质轻度纤维组织增生、支气管慢性炎症和小叶中央型肺气肿样病变,观察1a(年)未见明显纤维化。 相似文献
74.
热力学计算表明,H2,N2的过量有助于提高TiN的产率,但能耗也相应增加。为此考察了温度,流量,TiCl4携带量,混合方式对产物性能的影响。结果表明,流量增加,温度升高,TiCl4携带量增加,混合愈好,则产物粒径愈小。在此基础上采用微波等离子体化学气相沉积法,合成了粒径为123-284nm的TiN超细颗粒 相似文献
75.
This study determined the accuracy of fit of three-unit fixed partial dentures joined by an infrared soldering technique compared with one-piece fixed partial denture castings and individually cast crowns. Wax patterns of prepared Ivorine teeth, maxillary left central incisor and maxillary left canine, were injection molded; a plastic rod was used as a pontic. One group of patterns was cast as one-piece dentures; the other group was sectioned in the connector area, cast individually and then joined by infrared soldering. Castings were seated on their respective dies, embedded in epoxy resin, and sectioned. Gap distances between the casting and the die were measured at specified marginal sites with a profile projector. Results showed that the fit of infrared-soldered fixed partial dentures was significantly better than that of one-piece castings and was comparable with the fit of single crowns. The gap openings measured in all castings were within the range of clinical acceptability. 相似文献
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本文以病例—对照的方法探讨了在黑龙江省与鼻咽癌发生有关的危险因素。调查鼻咽癌病例及对照共127对。在单因素与条件Logistic回归分析中均表明幼儿期食咸鱼(OR=5.5, χ2=4.92, P<0.05)及长期生活在烧煤的环境中(OR=1.894, χ2=4.655, P<0.05)可能与鼻咽癌的发生有关。此外,条件Logistic回归分析还发现,鼻窦炎病史也可能与鼻咽癌的发生有联系(B=1.385, exp(B)=3,995, P<0.1)。在对病例及对照的一级亲属患恶性肿瘤情况的调查中发现,鼻咽癌病例组有肿瘤家族史者多于对照组,其差异有统计学意义(χ2=10.32, P<0.01)。 相似文献
78.
胡怀强 《河南中医学院学报》2003,18(6):83-85
中医药对中风后遗症治疗方法主要包括:①辨证分型治疗;②主方加减治疗,具体包括补气活血方、滋补肝肾方和健脾益气方;③虫类药治疗;④单味药治疗。但是,今后应把中医药、针灸、推拿等方法综合应用于临床,以便取得更好的疗效。同时应加强临床科研设计和实验研究,使中医药治疗中风后遗症更上一个层次。 相似文献
79.
Weimin Hu Kentaro Ninomiya Hiroko Ishibashi Naho Maruyama Haruyuki Oshima Hideyo Yamaguchi Shigeru Abe 《Medical mycology》2007,45(2):143-148
We established a novel murine model of pharyngeal candidiasis maintaining stable yeast population and local symptoms characteristic of pharyngeal thrush. The persistent Candida-infection was prolonged by inhalation of beclomethasone dipropionate corticosteroid. The severity of infection lesions was evaluated by determining viable cell number of Candia albicans and scores representing symptomatic curd-like white patch on pharyngeal tissue. The utility of this model was shown by the disappearance of lesions and fungal cells after treatment with fluconazole (FLCZ). The model would be useful for evaluating new chemotherapeutic or immunotherapeutic approaches against pharyngeal candidiasis, as well as in pathological studies. 相似文献
80.
Preparation and evaluation of lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin. 总被引:5,自引:0,他引:5
Yashu Yin Dawei Chen Mingxi Qiao Zhe Lu Haiyang Hu 《Journal of controlled release》2006,116(3):337-345
The purpose of this study was to design and evaluate lectin-conjugated PLGA nanoparticles for oral delivery of thymopentin. Thymopentin loaded PLGA nanoparticles (TP5-NPs) were prepared by a double emulsion-solvent evaporation technique. Novel WGA-PLGA conjugates were synthesized by coupling the amino groups of wheat germ agglutinin (WGA) to the carbodiimide-activated carboxylic groups of PLGA, and were incorporated into nanoparticles preparation to take mucoadhesive properties. Important characteristics such as particle size, zeta potential, entrapment efficiency, storage stability, as well as in vitro drug release behavior were investigated. The retention of biorecognitive activity of WGA after covalent coupling was confirmed by haemagglutination test. In vitro experiments with pig mucin (PM) demonstrated that the conjugation of WGA enhanced the interaction about 1.8-4.2 fold compared with that of the non-conjugated nanoparticles, and still exhibited sugar specificity. The pharmacodynamical studies on oral administration of WGA-TP5-NPs were performed in FACScan flow cytometry. The values of CD4(+)/CD8(+) ratios were significantly increased compared with that of TP5-NPs (p<0.01). The enhanced uptake was related to the increasing of WGA content on nanoparticles. These results confirmed that the conjugation of WGA onto PLGA nanoparticles effectively improved the intestinal absorption of TP5 due to specific bioadhesion on GI cell membrane. 相似文献