妊娠期糖尿病孕妇与正常孕妇血清铬含量的研究

目的　通过对血清铬含量的测定 ,探讨妊娠期糖尿病孕妇是否缺铬。方法　 2 0 0 0～ 2 0 0 1年 ,选择妊娠期糖尿病孕妇 5 0例 ,正常孕妇 4 7例 ,以电感耦合高频等离子体发射光谱法 (ICP AES)测定两组孕妇血清铬含量。结果　妊娠期糖尿病孕妇血清铬含量较正常孕妇明显降低 ,差异有显著性意义 (P <0 0 5 )。结论　建议妊娠期糖尿病孕妇适量补铬     

水中微量甲胺磷农药的检验

目的选择检出水中微量甲胺磷农药的最佳方案。方法分别使用液-液萃取法、固相萃取法、活性炭富集法提取甲胺磷含量极低的液体检材，提取液经MS／GC检验。结果液-液萃取法为阴性结果，固相萃取法、活性炭富集法为阳性结果。结论实验表明对于常规液-液萃取方法效果欠佳的甲胺磷含量极低的液体检材，采取固相萃取法或活性炭富集法进行萃取，可提高检出率。     

萘普生栓治疗产后宫缩痛临床观察

目的了解萘普生栓(NaproxenSuppositories)治疗产后宫缩痛的效果。方法对285例产后宫缩痛的产妇随机分成两组,实验组用萘普生一枚(0﹒25g)塞入肛门内2cm。对照组口服去痛片2片,记录疼痛开始减轻时间,镇痛效果、镇痛持续时间。结果①用药后15分钟疼痛开始减轻者:实验组80例,占55.17﹪;对照组0例。②疼痛缓解者:实验组108例,占74.5﹪。对照组60例,占42.8﹪。③镇痛时间超过8小时者:实验组110例,占79.1﹪。对照组20例,占16.7﹪。结论萘普生栓治疗产后宫缩痛高效、快速、持久。     

甘草体外抑制呼吸道合胞病毒作用研究

目的:开发安全有效的抗呼吸道合胞病毒的新药.方法:采用细胞病变抑制实验观察甘草在Hela细胞中对呼吸道合胞病毒的抑制作用.结果:甘草半数中毒浓度(TC50)为3.43g/L;抑制呼吸道合胞病毒的半数有效浓度(EC50)为0.2535g/L,治疗指数(TI)为13.53;甘草对呼吸道合胞病毒的抑制作用存在量效反应关系;在感染后0 h、2 h、4 h、6 h、8 h,甘草均有抑制呼吸道合胞病毒的作用.结论:甘草在Hela细胞中对呼吸道合胞病毒有明显的抑制作用,其作用机制是多途径的.     

鹿茸口服液对抗氧化酶的影响

目的:研究鹿茸口服液对青年及老年小鼠的抗氧化作用.方法:灌服鹿茸口服液后,测定小鼠SOD、CAT和GSHpx活性及MDA含量.结果:鹿茸口服液对老年小鼠SOD活性增强和MDA含量降低作用均明显强于对青年小鼠,并能增强老年小鼠肝CAT和GSHpx活性.结论:鹿茸口服液对老年小鼠具有抗氧化作用.     

肾上腺转移性肿瘤的彩色多普勒超声诊断及临床价值

目的探讨彩色多普勒超声诊断肾上腺转移性肿瘤的临床应用价值。方法回顾性分析52例经手术病理、CT、核磁共振相印证的转移性肾上腺肿瘤的超声资料。结果转移性肾上腺肿瘤呈圆形、椭圆形或不规则形,大小相差悬殊,肿块小于3cm者多为均质低回声,大于3cm者为不均匀强弱不等回声,边界较清,肿块内血供不丰富,可探及点状血流信号,为低速高阻动脉血流。本组4例误漏诊病例中,2例误诊为右肝肿瘤;2例因左侧肾上腺肿瘤小于1.5cm未发现而漏诊。彩色多普勒超声诊断肾上腺转移性肿瘤正确率为92.31%。结论超声可以从病灶大小、有无包膜和血流情况等征象来诊断和鉴别诊断肾上腺肿瘤。     

二羧乙基锗倍半氧化物的抗大鼠实验性胃溃疡作用及其作用机理研究

二羧乙基锗倍半氧物(Dicarboxyethyl GermaniumSesquioxide,DEG)是人工合成的有机锗化合物。它能对抗Shay幽门结扎性溃疡的形成,使胃液中PGE_2含量增加,胃蛋白酶活性和游离酸度明显降低。DEG还能对抗消炎痛型,五肽胃泌素型和酒精型溃疡的形成,促进醋酸型溃疡的愈合,但对应激型和利血平型溃疡无对抗作用。DEG的主细胞分泌功能比对照组明显减弱。实验结果表明,DEG的抗溃疡作用可能与增加胃内PGE_2含量、抑制胃液分泌和促进蛋白质合成有关。     

心理干预对子宫肌瘤患者术后性功能的影响

目的 探讨心理干预对子宫肌瘤患者术后性功能的影响.方法 将子宫肌瘤患者分为干预组和非干预组,对干预组的患者进行术前的认知行为治疗,采用女性性功能调查表对干预组和非干预组手术前后性功能进行评估.结果 干预组术后性功能评分显著优于非干预组.结论 手术前心理干预对于子宫肌瘤患者术后性功能的改善有重要作用.     

Development of cyclosporin A-loaded hyaluronic microsphere with enhanced oral bioavailability

To develop a hyaluronic microsphere with the improved oral bioavailability of poorly water-soluble cyclosporin A (CsA), the microspheres were prepared with varying ratios of sodium hyaluronate (HA)/sodium lauryl sulfate (SLS)/CsA using a spray-drying technique. The effects of HA and SLS on the dissolution and solubility of CsA in microspheres were investigated. The CsA-microsphere prepared with HA/SLS/CsA at the ratio of 4/2/1 gave the highest solubility and dissolution rate of CsA among those formulae tested. As solubility and dissolution rate of CsA were increased about 17- and 2-fold compared to CsA powder, respectively, this CsA-microsphere was selected as an optimal formula for oral delivery in rats. The CsA-microsphere and Sandimmun neoral sol gave significantly higher blood levels compared with CsA powder alone. Moreover, the AUC, T(max) and C(max) values of CsA in CsA-microsphere were not significantly different from those in Sandimmun neoral sol in rats, indicating that CsA-microsphere was bioequivalent to the commercial product in rats. Our results demonstrated that the CsA-microsphere prepared with HA and SLS, with improved bioavailability of CsA, might have been useful to deliver a poorly water-soluble CsA.     

Unusual morphologic features of low‐grade endometrial stromal sarcoma: A case report

BackgroundEndometrial stromal tumours are uncommon tumours of the uterus. They mainly occur in perimenopausal women. Tumours with typical clinicopathological features do not usually pose diagnostic problems. However, rare clinicopathological features can occur, and clinicians without significant experience may have difficulty diagnosing these tumours and managing these patients.MethodsHerein, we report a case of endometrial stromal sarcoma that occurred in a 25‐year‐old woman. The pathological features, immunophenotype, treatment and prognosis were discussed.ResultsThe tumour revealed morphological heterogeneity, and there were similar proliferative‐type endometrial stromal cells, an extensive amount of mature adipose tissue, and prominent rhabdomyoblastic and smooth muscle cells. Histopathological and immunohistochemical studies confirmed low‐grade endometrial stromal sarcoma with smooth muscle, adipocytic and rhabdomyoblastic differentiation (approximately 60% were differentiated tissues). The final treatment of the tumour was total abdominal hysterectomy with bilateral salpingo‐oophorectomy. There was no evidence of recurrence for 109 months postoperatively.ConclusionsWe found that low‐grade endometrial stromal tumours with extensive adipocytic and prominent rhabdomyoblastic differentiation are misdiagnosed because they are infrequent. They must be differentiated from rhabdomyosarcoma with accurate identification of adipocytes, and long‐term follow‐up is needed.