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991.
Continence for Women: Evidence-Based Practice 总被引:1,自引:0,他引:1
Carolyn M. Sampselle RNC PhD FAAN Patricia A. Burns NP PhD FAAN Molly C. Dougherty RN PhD FAAN Diane Kaschak Newman RNC MSN FAAN Karen Kelly Thomas RNC PhD Jean F. Wyman RN PhD CS FAAN 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1997,26(4):375-385
Approximately 20% of women ages 25–64 years experience urinary incontinence. The symptoms increase during perimenopause, when 31% of women report that they experience incontinent episodes at least once per month. Bladder training and pelvic muscle exercise are the recommended initial treatment and can be taught effectively in the ambulatory care setting. Bladder training enables women to accommodate greater volumes of urine and extend between-voiding intervals. Pelvic muscle exercise increases muscle strength and reduces unwanted urine leakage. Accumulated research results provide evidence-based guidelines for nursing practice. The Association of Women's Health, Obstetric, and Neonatal Nurses has identified continence for women as the focus of its third research utilization project. This article presents the rationale, evidence base, and educational strategies compiled by the Research Utilization 3 Nurse Scientist Team. Nurses can enable women to incorporate these noninvasive techniques into self-care. 相似文献
992.
Women's Sense of Well-Being Before and After Hysterectomy 总被引:3,自引:0,他引:3
993.
994.
Luft HS Garnick DW Phibbs CS Peltzman DJ Lichtenberg E McPhee SJ 《Journal of health care marketing》1991,11(3):2-11
The authors apply a conditional choice model to simulate the results of patient and physician choices of hospitals for a specific surgical procedure in response to improvements in quality or changes in charges. The model includes all zip code areas and relevant hospitals in a large metropolitan area and estimates the impact on admissions at each hospital. It can be used to estimate both the impact of decisions by a given hospital and the potential responses of competitors, as well as the effects of selective contracting with hospitals by certain payors. 相似文献
995.
Post‐traumatic Stress Disorder and Antepartum Complications: a Novel Risk Factor for Gestational Diabetes and Preeclampsia
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996.
C Chantler JE Carter M Bewick R Counahan JS Cameron CS Ogg DG Williams E Winder 《Archives of disease in childhood》1980,55(6):435-445
75 children aged under 15 years have entered the regular haemodialysis/renal transplant programme at Guy's Hospital in the 10 years since its inception; 13 children have subsequently died. A combination of hospital and home haemodialysis and renal transplantation was used. 64 children received 80 renal allografts; 37 1st grafts were from live, related donors and 27 were from cadaver donors. The 5-year acturial patient survival for the whole group and for those who had transplants was 76%. Live donor graft survival was 65% at 3 years, and 55% at 5 years; 1st cadaver graft survival was 42% at 3 years. Results obtained during the last 6 years of the 10-year period showed an improvement with a live related donor graft survival rate of 71%, and a 1st cadaver graft survival rate of 47% at 3 years. Particular experience was gained with home haemodialysis and live, related donor transplantation. Despite growth, and psychosocial and rehabilitation problems, the overall results were encouraging, particularly for the 46 children who had successful transplants. These children grew better, had fewer psychosocial difficulties, and were rehabilitated more successfully into normal life than those on long-term dialysis. We conclude that dialysis and transplantation should be offered to all suitable children with terminal renal failure. 相似文献
997.
TM Barratt JS Cameron C Chantler R Counahan CS Ogg JF Soothill 《Archives of disease in childhood》1977,52(6):462-463
A controlled trial of azathioprine treatment of steroid-responsive frequent-relapsing nephrotic syndrome of childhood failed to show a therapeutic effect on the stability of remission after withdrawal of corticosteroid treatment. 相似文献
998.
Ig repertoires generated at various developmental stages differ markedly in
diversity. It is well documented that Ig H chain genes in human fetal liver
are limited with regard to N-regional diversity and use of diversity
elements. It is unclear whether these characteristics persist in pre-B cell
H chain genes of adult bone marrow. Using Ig H chain CDR3 fingerprinting
and sequence analysis, we analyzed the diversity of Ig H chain third
complementarity determining regions (HCDR3) in adult bone marrow pre-B and
mature B lymphocytes. Pre-B cell HCDR3 sequences exhibited adult
characteristics with respect to HCDR3 size, distribution of N regions and
usage of diversity elements. This suggested that pre-B cells in adults are
distinct from fetal B cell precursors with regard to Ig H chain
diversification mechanisms. At the DNA sequence level, HCDR3 diversity in
mature B cells was similar to that in pre-B cells. Pre-B HCDR3s, however,
frequently contained a consecutive stretch of hydrophobic amino acids,
which were rare in mature B cells. We propose that highly hydrophobic pre-B
HCDR3s may be negatively selected on the basis of structural limitations
imposed by the antigen binding site. At the same time, usage of hydrophilic
HCDR3 sequences (thought to support HCDR3 loop formation) may be promoted
by positive selection.
相似文献
999.
Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27 总被引:14,自引:0,他引:14
Craig HD; Gunel M; Cepeda O; Johnson EW; Ptacek L; Steinberg GK; Ogilvy CS; Berg MJ; Crawford SC; Scott RM; Steichen-Gersdorf E; Sabroe R; Kennedy CTC; Mettler G; Beis MJ; Fryer A; Awad IA; Lifton RP 《Human molecular genetics》1998,7(12):1851-1858
Cerebral cavernous malformation (CCM) is a Mendelian model of stroke,
characterized by focal abnormalities in small intracranial blood vessels
leading to hemorrhage and consequent strokes and/or seizures. A significant
fraction of cases is inherited as an autosomal dominant trait with
incomplete penetrance. Among Hispanic Americans, virtually all CCM is
attributable to a founder mutation localized to 7q ( CCM1 ). Recent
analysis of non-Hispanic Caucasian kindreds, however, has excluded linkage
to 7q in some, indicating at least one additional CCM locus. We now report
analysis of linkage in 20 non-Hispanic Caucasian kindreds with familial
CCM. In addition to linkage to CCM1, analysis of linkage demonstrates
linkage to two new loci, CCM2 at 7p13-15 and CCM3 at 3q25.2-27. Multilocus
analysis yields a maximum lod score of 14.11, with 40% of kindreds linked
to CCM1, 20% linked to CCM2 and 40% linked to CCM3, with highly significant
evidence for linkage to three loci (linkage to three loci supported with an
odds ratio of 2.6 x 10(5):1 over linkage to two loci and 1.6 x 10(9):1 over
linkage to one locus). Multipoint analysis among families with high
posterior probabilities of linkage to each locus refines the locations of
CCM2 and CCM3 to approximately 22 cM intervals. Linkage to these three loci
can account for inheritance of CCM in all kindreds studied. Significant
locus- specific differences in penetrance are identified. These findings
have implications for genetic testing of this disorder and represent an
important step toward identification of the molecular basis of this
disease.
相似文献
1000.
目的 探讨胶质母细胞瘤(glioblastoma,GBM)发病的分子遗传学机理,确定GBM的发生发展主要和哪些染色体或染色体区域有关,哪些染色体区域上可能存在与GBM相关的肿瘤抑制基因(tumor suppressor gene,TSG)。方法 应用聚合酶链反应技术,采用荧光标记的引物和377型DNA序列自动分析仪,对21例GBM的所有22对常染色体上共计382个微卫星位点进行了杂合性丢失(loss of heterozygosity,LOH)分析,相邻2个微卫星位点之间的平均遗传学距离为10cM。结果 在所有被检测的染色体臂上都观察到LOH,其中以染色体10q、10p、9p、17p和13q的LOH率最高(>50%),这些染色体臂上已知的肿瘤抑制基因PTEN、DMBT1、p16、p53和Rb所在区域LOH率都较高;14q、3q、22q、11p、9q、19q上也存在较高的LOH率(>40.5%);首次发现多个共同微小丢失区域:9p22-23、10p12.2-14、10q21.3、13q12.1-14.1、13q14.3-31、17p11.2-12、17p13、3q24-27、11p12-13、14q31-32.3、14q21-24.1、22q13.2-13.3、4q35、4q31.1-31.2、6qtel、6q16.3。结论 GBM存在复杂的遗传学异常,涉及多条染色体臂。以10q、10p、9p、17p和13q的异常与GBM发生发展的关系最为密切。除了已知的肿瘤抑制基因PTEN、DMBT1、p16、p15、p53和Rb外,首次所发现的多个微小共同丢失区域上可能存在GBM相关的多个未知TSG。 相似文献