全文获取类型
收费全文 | 3278篇 |
免费 | 234篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 107篇 |
妇产科学 | 92篇 |
基础医学 | 368篇 |
口腔科学 | 33篇 |
临床医学 | 606篇 |
内科学 | 486篇 |
皮肤病学 | 55篇 |
神经病学 | 294篇 |
特种医学 | 56篇 |
外科学 | 296篇 |
综合类 | 39篇 |
一般理论 | 5篇 |
预防医学 | 491篇 |
眼科学 | 72篇 |
药学 | 222篇 |
中国医学 | 13篇 |
肿瘤学 | 247篇 |
出版年
2023年 | 19篇 |
2022年 | 27篇 |
2021年 | 55篇 |
2020年 | 38篇 |
2019年 | 47篇 |
2018年 | 70篇 |
2017年 | 55篇 |
2016年 | 65篇 |
2015年 | 85篇 |
2014年 | 81篇 |
2013年 | 172篇 |
2012年 | 223篇 |
2011年 | 272篇 |
2010年 | 135篇 |
2009年 | 100篇 |
2008年 | 230篇 |
2007年 | 263篇 |
2006年 | 222篇 |
2005年 | 221篇 |
2004年 | 250篇 |
2003年 | 213篇 |
2002年 | 184篇 |
2001年 | 14篇 |
2000年 | 13篇 |
1999年 | 24篇 |
1998年 | 36篇 |
1997年 | 40篇 |
1996年 | 30篇 |
1995年 | 25篇 |
1994年 | 18篇 |
1993年 | 18篇 |
1992年 | 12篇 |
1991年 | 25篇 |
1990年 | 4篇 |
1989年 | 14篇 |
1988年 | 17篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 21篇 |
1984年 | 17篇 |
1983年 | 22篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1980年 | 19篇 |
1979年 | 5篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1973年 | 4篇 |
排序方式: 共有3514条查询结果,搜索用时 15 毫秒
41.
Zaver M Bhujwalla Dmitri Artemov Kshama Natarajan Meiyappan Solaiyappan Peggy Kollars Paul E G Kristjansen 《Clinical cancer research》2003,9(1):355-362
PURPOSE: The availability of noninvasive techniques to detect the effects of antiangiogenic agents is critically important for optimizing treatment of cancer with these agents. Magnetic resonance imaging (MRI) is one such noninvasive technique that is routinely used clinically. EXPERIMENTAL DESIGN: In this study, we have evaluated the use of MRI of the intravascular contrast agent albumin-GdDTPA to detect the effects of the antiangiogenic agent TNP-470 on the vascular volume and permeability of the MatLyLu prostate cancer model. RESULTS: TNP-470-treated tumors demonstrated a significant decrease of vascular volume, as well as a significant reduction in vascular and permeable regions, compared with volume-matched control tumors. Although the fractional volume of permeable regions in the tumor decreased, the average value of tumor permeability did not decrease significantly. This was attributable to increase in permeability in some regions of the tumor. These regions were mostly associated with low vascular volume. ELISA assays of control and treated MatLyLu tumors also detected a significant increase of vascular endothelial growth factor in the TNP-470-treated tumors. CONCLUSION: MRI detected significant changes in tumor vascular characteristics after treatment with TNP-470. 相似文献
42.
A field of study for public health finance has never been adequately developed. Consequently, very little is known about the relationships, types, and amount of finances that fund the public health system in America. This research was undertaken to build on the sparse knowledge of public health finance by examining the value of performance measurement systems to financial analysis. A correlational study was conducted to examine the associations between public health system performance of the 10 essential public health services and funding patterns of 50 local health departments in a large state. The specific objectives were to investigate if different levels and types of revenues, expenditures, and other demographic variables in a jurisdiction are correlated to performance. Pearson correlation analysis did not conclusively show strong associations; however, statistically significant positive associations primarily between higher levels of performance and jurisdiction taxes per capita were found. 相似文献
43.
44.
Pan E Cao S Brodie PJ Callmander MW Randrianaivo R Rakotonandrasana S Rakotobe E Rasamison VE TenDyke K Shen Y Suh EM Kingston DG 《Journal of natural products》2011,74(5):1169-1174
Investigation of the Madagascan endemic plant Ambavia gerrardii for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the three new alkaloids 8-hydroxyeupolauridine (1), 9-methoxyeupolauridine 1-oxide (2), and 11-methoxysampangine (3) and the three known alkaloids 4-6. The structures of 1 and 2 were confirmed by synthesis. Compounds 3, 4, and 6 showed moderate to good antiproliferative activities, with IC50 values of 10.3, 3.5, and 0.60 μM, respectively, against the A2780 human ovarian cancer cell line and with IC50 values of 0.57, 1.77, and 0.58 μM, respectively, against the H460 human lung cancer cell line. 相似文献
45.
Annelou L.C. de Vries Thomas D. Steensma Theo A.H. Doreleijers Peggy T. Cohen‐Kettenis 《The journal of sexual medicine》2011,8(8):2276-2283
IntroductionPuberty suppression by means of gonadotropin‐releasing hormone analogues (GnRHa) is used for young transsexuals between 12 and 16 years of age. The purpose of this intervention is to relieve the suffering caused by the development of secondary sex characteristics and to provide time to make a balanced decision regarding actual gender reassignment.AimTo compare psychological functioning and gender dysphoria before and after puberty suppression in gender dysphoric adolescents.MethodsOf the first 70 eligible candidates who received puberty suppression between 2000 and 2008, psychological functioning and gender dysphoria were assessed twice: at T0, when attending the gender identity clinic, before the start of GnRHa; and at T1, shortly before the start of cross‐sex hormone treatment.Main Outcome MeasuresBehavioral and emotional problems (Child Behavior Checklist and the Youth‐Self Report), depressive symptoms (Beck Depression Inventory), anxiety and anger (the Spielberger Trait Anxiety and Anger Scales), general functioning (the clinician's rated Children's Global Assessment Scale), gender dysphoria (the Utrecht Gender Dysphoria Scale), and body satisfaction (the Body Image Scale) were assessed.ResultsBehavioral and emotional problems and depressive symptoms decreased, while general functioning improved significantly during puberty suppression. Feelings of anxiety and anger did not change between T0 and T1. While changes over time were equal for both sexes, compared with natal males, natal females were older when they started puberty suppression and showed more problem behavior at both T0 and T1. Gender dysphoria and body satisfaction did not change between T0 and T1. No adolescent withdrew from puberty suppression, and all started cross‐sex hormone treatment, the first step of actual gender reassignment.ConclusionPuberty suppression may be considered a valuable contribution in the clinical management of gender dysphoria in adolescents. de Vries ALC, Steensma TD, Doreleijers TAH, and Cohen‐Kettenis PT. Puberty suppression in adolescents with gender identity disorder: A prospective follow‐up study. J Sex Med 2011;8:2276–2283. 相似文献
46.
Aviad Haramati Sian Cotton Jamie S. Padmore Hedy S. Wald Peggy A. Weissinger 《Medical teacher》2017,39(2):118-119
The high prevalence of physician burnout is of great concern and may begin with observed declines in empathy and increases in stress and burnout in medical and health professions students. While underlying causes have been described, there is less certainty on how to create effective interventions in curricula and workplace. In October 2015, The Center for Innovation and Leadership in Education (CENTILE) at Georgetown University, together with MedStar Health, Georgetown’s clinical partner, and six academic institutions sponsored a conference in Washington, DC. The goal was to discuss the current state of stress and burnout in the health professions, and to share best practices on strategies to promote resilience, empathy and well-being in students, residents, faculty and practitioners across health professions. In this issue of Medical Teacher, three articles address pertinent themes of the conference. Maslach and Leiter provide insights into burnout and strategies to alleviate it. Ekman and Krasner discuss various types of empathy and how neuroscience can be used to effectively cultivate empathy. In the third paper, Kreitzer and Klatt highlight three successful curricular interventions that foster self-awareness and boost resilience. Ultimately, effective strategies will be needed to address this issue at both the individual and organizational levels. 相似文献
47.
48.
Meredith A. Dilley Mallikarjuna Rettiganti Lynn Christie Erin OBrien Megan Patterson Connelly Weeks Julia Aronson Amy M. Scurlock Tamara T. Perry Robbie D. Pesek Matthew C. Bell Joshua L. Kennedy Peggy Chandler James Magee Larry Simmons Sheva K. Chervinskiy Patrick Casey Stacie M. Jones 《Pediatric allergy and immunology》2019,30(3):363-369
49.
50.
Food has both nutritional and non‐nutritional functions and this paper reports some non‐nutritional uses of food in traditional Appalachian culture. The emphasis is upon occult and non‐occult uses of food in folk medicine. Specific examples of rituals are presented as collected in Appalachia. It is suggested that these traditions have been maintained due to the strength of the reference groups. 相似文献