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Jiménez Isabel Carabia Júlia Bobillo Sabela Palacio Carles Abrisqueta Pau Pagès Carlota Nieto Juan C. Castellví Josep Martínez-Ricarte Francisco Escoda Lourdes Perla Cristóbal Céspedes Torrez Dennis H. Boix Joan Purroy Noelia Puigdefàbregas Lluís Seoane Joan Bosch Francesc Crespo Marta 《Journal of neuro-oncology》2020,149(1):13-25
Journal of Neuro-Oncology - Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells... 相似文献
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Peter Kochunov L. Elliot Hong Emily L. Dennis Rajendra A. Morey David F. Tate Elisabeth A. Wilde Mark Logue Sinead Kelly Gary Donohoe Pauline Favre Josselin Houenou Christopher R. K. Ching Laurena Holleran Ole A. Andreassen Laura S. van Velzen Lianne Schmaal Julio E. Villaln-Reina Carrie E. Bearden Fabrizio Piras Gianfranco Spalletta Odile A. van den Heuvel Dick J. Veltman Dan J. Stein Meghann C. Ryan Yunlong Tan Theo G. M. van Erp Jessica A. Turner Liz Haddad Talia M. Nir David C. Glahn Paul M. Thompson Neda Jahanshad 《Human brain mapping》2022,43(1):194-206
The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive–compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA-defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross-diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large-scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross-diagnosis features. 相似文献
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Improving the analysis of routine outcome measurement data: what a Bayesian approach can do for you
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Rivka M. de Vries Rob R. Meijer Vincent van Bruggen Richard D. Morey 《International journal of methods in psychiatric research》2016,25(3):155-167
Since recent decades, clinicians offering interventions against mental problems must systematically collect data on how clients change over time. Since these data typically contain measurement error, statistical tests have been developed which should disentangle true changes from random error. These statistical tests can be subdivided into two types: classical tests and Bayesian tests. Over the past, there has been much confusion among analysts regarding the questions that are answered by each of these tests. In this paper we discuss each type of test in detail and explain which questions are, and which are not, answered by each of the types of tests. We then apply a test of each type on an empirical data set and compare the results. Copyright © 2015 John Wiley & Sons, Ltd 相似文献
96.
Eva Bernal Antoni Bayés-Genís Albert Ariza-Solé Francesc Formiga Maria T. Vidán Luis Alberto Escobar-Robledo Jaime Aboal Lídia Alcoberro Carme Guerrero Iván Ariza-Segovia Ana Hernández de Benito Pau Vilardell José Carlos Sánchez-Salado Victoria Lorente Antoni Bayés de Luna Manuel Martinez-Sellés 《Journal of electrocardiology》2018,51(4):747
97.
Puig N de la Rubia J Jarque I Salavert M Montesinos P Sanz J Martín G Sanz G Cantero S Lorenzo I Sanz MA 《International journal of hematology》2007,86(2):186-192
Infectious complications are a major cause of morbidity and mortality in patients who undergo autologous stem cell transplantation (ASCT). We examined 476 patients with hematologic malignancies (401) or solid tumors (75) who underwent ASCT between February 1990 and May 2005. Anti-infectious prophylaxis consisted of different combinations of ciprofloxacin, cotrimoxazole, fluconazole, aerosolized amphotericin B, acyclovir, and intravenous immunoglobulins. Overall, 454 patients (95%) developed fever in the first 60 days after ASCT. In the majority of patients, initial antibiotic therapy consisted of broad-spectrum beta-lactamic with or without amikacin. A glycopeptide was administered as initial therapy in 86 cases. Overall, there were 132 (29%) clinically documented infections (37 pneumonias), 79 (17%) microbiologically documented infections (65 bacteremias), and 243 (54%) fevers of unknown origin. Coagulase-negative staphylococci (18, 25%) and E coli (18, 25%) were the organisms most frequently isolated. The pattern of infection did not change throughout the study except for a significantly higher incidence of bacteremia due to gram-positive bacteria in the first 5 years of the study. Infection-related mortality was 5% (21 cases), with pneumonia the most frequent cause of death. ASCT should be considered a low-risk procedure, although new therapeutic approaches for patients developing severe respiratory infections are still needed. 相似文献
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Pau Golanó Jordi Vega Peter A. J. de Leeuw Francesc Malagelada M. Cristina Manzanares Víctor Götzens C. Niek van Dijk 《Knee surgery, sports traumatology, arthroscopy》2010,18(5):557-569
Understanding the anatomy of the ankle ligaments is important for correct diagnosis and treatment. Ankle ligament injury is
the most frequent cause of acute ankle pain. Chronic ankle pain often finds its cause in laxity of one of the ankle ligaments.
In this pictorial essay, the ligaments around the ankle are grouped, depending on their anatomic orientation, and each of
the ankle ligaments is discussed in detail. 相似文献
100.