全文获取类型
收费全文 | 118846篇 |
免费 | 47341篇 |
国内免费 | 161篇 |
专业分类
耳鼻咽喉 | 1899篇 |
儿科学 | 5621篇 |
妇产科学 | 1712篇 |
基础医学 | 21829篇 |
口腔科学 | 6000篇 |
临床医学 | 19219篇 |
内科学 | 31073篇 |
皮肤病学 | 8300篇 |
神经病学 | 17480篇 |
特种医学 | 3220篇 |
外科学 | 18477篇 |
综合类 | 646篇 |
一般理论 | 87篇 |
预防医学 | 9690篇 |
眼科学 | 1838篇 |
药学 | 8156篇 |
2篇 | |
中国医学 | 1077篇 |
肿瘤学 | 10022篇 |
出版年
2023年 | 241篇 |
2022年 | 404篇 |
2021年 | 2168篇 |
2020年 | 5540篇 |
2019年 | 11588篇 |
2018年 | 10991篇 |
2017年 | 12065篇 |
2016年 | 12750篇 |
2015年 | 12784篇 |
2014年 | 13095篇 |
2013年 | 14291篇 |
2012年 | 7188篇 |
2011年 | 7318篇 |
2010年 | 10648篇 |
2009年 | 6731篇 |
2008年 | 5115篇 |
2007年 | 3923篇 |
2006年 | 3980篇 |
2005年 | 3556篇 |
2004年 | 3476篇 |
2003年 | 3331篇 |
2002年 | 3303篇 |
2001年 | 1215篇 |
2000年 | 1059篇 |
1999年 | 759篇 |
1998年 | 577篇 |
1997年 | 510篇 |
1996年 | 461篇 |
1995年 | 402篇 |
1994年 | 400篇 |
1993年 | 376篇 |
1992年 | 378篇 |
1991年 | 357篇 |
1990年 | 329篇 |
1989年 | 280篇 |
1988年 | 312篇 |
1987年 | 278篇 |
1986年 | 244篇 |
1985年 | 259篇 |
1984年 | 284篇 |
1983年 | 270篇 |
1982年 | 332篇 |
1981年 | 280篇 |
1980年 | 256篇 |
1979年 | 196篇 |
1978年 | 181篇 |
1977年 | 159篇 |
1975年 | 142篇 |
1974年 | 151篇 |
1973年 | 143篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
181.
182.
183.
184.
Fluid role boundaries: exploring the contribution of the advanced nurse practitioner to multi‐professional palliative care
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
185.
J.J. Crowley R.B. Warren J.C. Cather 《Journal of the European Academy of Dermatology and Venereology》2019,33(9):1676-1684
Psoriasis is a chronic disease that requires long‐term treatment. Consequently, understanding the safety and tolerability of any potential treatment over time is critical to effective prescribing. The biologic agents currently available for the treatment of psoriasis target a number of different inflammatory cytokines involved in psoriasis disease pathogenesis. The monoclonal antibodies tildrakizumab, guselkumab and risankizumab target the p19 subunit that is specific to interleukin (IL)‐23. This article reviews published data on the safety of these IL‐23p19 inhibitors in patients with psoriasis compared with other currently available biologic therapies. Data from randomized, placebo‐ and active‐controlled phase 3 clinical trials show tildrakizumab, guselkumab and risankizumab to have a favourable risk–benefit profile in patients with moderate to severe psoriasis. No significant safety concerns have been observed for any of these IL‐23p19 inhibitors in the data published to date. The most commonly reported adverse events (AEs) associated with these agents in phase 3 studies were upper respiratory tract infections. No increase was seen in rates of serious infections, malignancies or major adverse cardiovascular events, with no signals suggestive of an elevated risk of opportunistic infections, active tuberculosis or reactivation of latent tuberculosis infection, mucocutaneous Candida infections, triggering or worsening of inflammatory bowel disease, demyelinating disorders or suicidal ideation. Selectively targeting IL‐23p19 may help avoid AEs that have been associated with biologic agents with other mechanisms of action. Data from long‐term extension studies and patient registries will further establish the safety profile of IL‐23p19 inhibitors for the treatment of moderate to severe psoriasis in routine practice. 相似文献
186.
Bryan E.K. Guevara Suhail Saleem Wan‐Ting Chen Pa‐Fan Hsiao Yu‐Hung Wu 《Journal of cutaneous pathology》2019,46(5):347-352
Lucio phenomenon is an atypical reaction of leprosy, characterized by vasculitic lesions that can mimic antiphospholipid syndrome (APS) clinically. Distinguishing the two can be difficult as antiphospholipid autoantibodies may be present in patients with leprosy. We report on a 32‐year‐old female patient presenting with a sudden onset of fever, hemorrhagic bullae, and skin necrosis on her lower legs. She was treated for APS due to the presence of antiphospholipid antibodies but had an inadequate response. A skin biopsy revealed thrombotic vasculopathy and necrotizing vasculitis associated with aggregation of foam cells in the perivascular area and subcutis, with acid‐fast bacilli in the histiocytes and blood vessel walls. Direct immunofluorescence showed IgM, C3, and fibrinogen deposition in the superficial and deep dermal blood vessels. The pathology confirmed the diagnosis of Lucio phenomenon, and appropriate therapy was given. It is essential to evaluate the patient comprehensively, including clinical, serological, and pathological aspects, to obtain the correct diagnosis. 相似文献
187.
188.
Victoria Alegría‐Landa Heinz Kutzner Luis Requena 《Journal of cutaneous pathology》2019,46(11):867-871
Carcinosarcomas are biphasic tumors composed of admixed malignant epithelial and mesenchymal components. Numerous terms have been used to name such neoplasms; therefore, terminological confusion is frequent. Most examples of carcinosarcomas are encountered in non‐cutaneous sites, with approximately 100 cases of cutaneous carcinosarcomas reported so far in the English literature. Although different theories have been suggested to explain the occurrence of these peculiar neoplasms, histogenetic mechanisms should be better hypothesized depending on each individual case. Even though prognosis tends to be related to the specific components of the lesion, especially the epithelial one, it seems that cases of cutaneous localization usually have a better outcome. We report an exceedingly rare case of syringocystadenocarcinoma papilliferum which showed an atypical stroma with sarcomatoid appearance, and highlight that the terminology used for this spectrum of lesions is disorganized and confusing. 相似文献
189.
190.