全文获取类型
收费全文 | 4912篇 |
免费 | 195篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 119篇 |
妇产科学 | 175篇 |
基础医学 | 481篇 |
口腔科学 | 73篇 |
临床医学 | 354篇 |
内科学 | 1364篇 |
皮肤病学 | 91篇 |
神经病学 | 663篇 |
特种医学 | 145篇 |
外科学 | 671篇 |
综合类 | 10篇 |
一般理论 | 2篇 |
预防医学 | 155篇 |
眼科学 | 143篇 |
药学 | 242篇 |
中国医学 | 22篇 |
肿瘤学 | 344篇 |
出版年
2023年 | 48篇 |
2022年 | 92篇 |
2021年 | 149篇 |
2020年 | 97篇 |
2019年 | 106篇 |
2018年 | 146篇 |
2017年 | 95篇 |
2016年 | 123篇 |
2015年 | 121篇 |
2014年 | 197篇 |
2013年 | 234篇 |
2012年 | 369篇 |
2011年 | 352篇 |
2010年 | 213篇 |
2009年 | 205篇 |
2008年 | 330篇 |
2007年 | 289篇 |
2006年 | 268篇 |
2005年 | 278篇 |
2004年 | 230篇 |
2003年 | 229篇 |
2002年 | 202篇 |
2001年 | 68篇 |
2000年 | 66篇 |
1999年 | 69篇 |
1998年 | 41篇 |
1997年 | 31篇 |
1996年 | 33篇 |
1995年 | 38篇 |
1994年 | 31篇 |
1993年 | 17篇 |
1992年 | 39篇 |
1991年 | 51篇 |
1990年 | 24篇 |
1989年 | 30篇 |
1988年 | 27篇 |
1987年 | 14篇 |
1986年 | 17篇 |
1985年 | 19篇 |
1984年 | 23篇 |
1983年 | 18篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 13篇 |
1979年 | 11篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1972年 | 4篇 |
排序方式: 共有5135条查询结果,搜索用时 0 毫秒
21.
22.
Anania Pasquale Battaglini Denise Balestrino Alberto DAndrea Alessandro Prior Alessandro Ceraudo Marco Rossi Diego Criminelli Zona Gianluigi Fiaschi Pietro 《Neurosurgical review》2021,44(3):1243-1253
Neurosurgical Review - Posterior cranial fossa tumours frequently develop hydrocephalus as first presentation in up to 80% of paediatric patients and 21.4% of adults, although it resolves after... 相似文献
23.
Nocturnal Paroxysmal Dystonia with Short-Lasting Attacks: Three Cases with Evidence for an Epileptic Frontal Lobe Origin of Seizures 总被引:9,自引:6,他引:3
Paolo Tinuper Angelina Cerullo Fabio Cirignotta Pietro Cortelli Elio Lugaresi Pasquale Montagna 《Epilepsia》1990,31(5):549-556
The epileptic or nonepileptic origin of nocturnal paroxysmal dystonia (NPD) has been debated. We studied three patients with frequent attacks during non-REM sleep. During prolonged video-EEG monitoring, two patients had a convulsive seizure after a typical NPD episode and on these occasions EEG showed epileptiform discharge. In the three patients, attacks occurred repeatedly with different intensity, representing "fragments" of the same seizure. These fragments of the attack could occur periodically every 20-40 s. We postulate that short NPD attacks are actually epileptic seizures originating from the frontal lobes. The rhythmicity of the episodes may be due to rhythmic oscillation of cortical function during non-REM sleep. 相似文献
24.
The authors describe a series of surgical approaches that they found particularly useful for the exposure and removal of lesions involving the skull base. These are: 1) fronto-naso-orbital approach; 2) frontotemporo-orbito-zygomatic approach; 3) subtemporal transpetrosal approach; 4) temporo-suboccipital transpetrosal approach (retrolabyrinthine presigmoid; transsigmoid; translabyrintine amend transcochlear presigmoid); 5) dorsolateral approach to the foramen magnum and lower clivus.As the approaches are complex and carry potential risks of morbidity, not only it is important to have a good knowledge of basic anatomy but also to closely follow the indications for each one. In this type of surgery where it is often difficult to achieve complete removal of the lesion by a single route of attack, more than one approach may be employed in different surgical steps. Finally, all these approaches demand extremely scrupulos surgical reconstruction to avoid dangerous postoperative complications that may jeopardize the previous work of the surgeon. 相似文献
25.
Structural and functional macrophages alterations by ceramics of different composition 总被引:2,自引:0,他引:2
Bosetti M Ottani V Kozel D Raspanti M De Pasquale V Ruggeri A Cannas M 《Biomaterials》1999,20(4):363-370
Biomaterials may initiate several and complex biological reactions in host tissues, and the cell-biomaterial interactions can determine the release of mediators including monocytes and lymphocytes chemotactic factors. The present work was aimed to investigate in vitro the macrophage biological reactions of a natural apatite obtained by heat treatment at 400 degrees C of bovine bone, compared to other ceramics usually used for dental and orthopedic applications, using synthetic apatite and three types of alumina as controls. Particles chemotactic activity and powders oxidative burst evidenced no monocyte macrophages sensitivity reaction for natural and synthetic hydroxyapatite powders at great granulometry (> 50 microm); data were confirmed by ultrastructural observations; electron microscopy analysis showed macrophages with the features of healthy cells in the presence of both natural and synthetic apatites while macrophages grown in the presence of alumina seemed to be negatively affected. In conclusion, among all ceramics tested, natural apatite displayed a good compatibility with living cells, being better tolerated than synthetic hydroxyapatite which in turn is better tolerated than alumina. 相似文献
26.
27.
Di Pasquale G Passarelli P Ribani MA Borgatti ML Urbinati S Pinelli G 《Archives of gerontology and geriatrics》1996,23(3):329-336
In patients with heart failure the incidence of thromboembolism is 0.9-5.5%/year (mean 1.9%/year), but no randomized studies are available to support the indication for anticoagulant therapy in those patients. Atrial fibrillation and previous thromboembolic events seem to be the major risk factors, whereas the effect of ventricular dysfunction has not been independently evaluated; nonetheless several studies suggest that thromboembolism is more likely among those patients with lower ejection fraction and lower peak exercise oxygen consumption. Anticoagulant therapy seems to be indicated also in patients with left ventricular aneurysm with mobile and protruding thrombi. Several studies of patients with dilated cardiomyopathy show that the incidence of thromboembolism ranges from 1.6 to 4.5%/year in patients not treated with anticoagulants, while it is virtually absent in anticoagulated patients. The clinical opportunity of long-term anticoagulant treatment in heart failure patients should be weighted not only on the clinical markers of thromboembolic risk, but also on the relative risk/benefit ratio of the single patient. 相似文献
28.
Emanuele Nicolai Alberto Cuocolo Leonardo Pace Antonio Nappi Pasquale Sullo Stefania Cardei Luigi Argenziano Fiorenzo Squame Peter J. Ell Marco Salvatore 《Journal of nuclear cardiology》1996,3(1):9-17
Background
Exercise and dipyridamole 99mTc-labeled methoxy isobutyl isonitrile (MIBI) myocardial scintigraphy have been widely used for the diagnosis of coronary artery disease (CAD). However, only limited data on adenosine 99mTc-labeled MIBI cardiac imaging are currently available. This study was designed to assess the accuracy of quantitative adenosinerest 99mTc-labeled MIBI tomography in the diagnosis and localization of CAD.Methods and Results
Fifty-seven consecutive patients with suspected CAD who underwent coronary angiography and 22 normal volunteers were studied. All patients underwent 99mTc-labeled MIBI tomography after administration of adenosine (140 μg/kg intravenously for 6 minutes) and at rest. A total of 171 vascular coronary territories were analyzed quantitatively. All patients with CAD (≥50% luminal stenosis) (n=55) had abnormal 99mTc-labeled MIBI tomograms. The normalcy rate was 86% by quantitative analysis. Overall sensitivity, specificity, and diagnostic accuracy for detection of individual stenosed vessels were 84%, 87%, and 85%, respectively. In patients with one-vessel CAD (n=24), sensitivity and diagnostic accuracy in the detection of individual stenosed vessels were significantly (p<0.05) higher compared with patients with multivessel CAD (n=31). Moreover, 75% of patients with one-vessel disease showed a scintigraphic pattern characterized by the presence of perfusion defects in only one coronary artery territory, and 74% of patients with multivessel disease showed a scintigraphic pattern characterized by the presence of perfusion defects in two or more coronary artery territories. Sensitivity, specificity, and diagnostic accuracy for detecting individual diseased vessels were similar in patients without previous myocardial infarction (n=18) compared with those with previous myocardial infarction (n=39). In myocardial territories related to noninfarcted areas (n=124), sensitivity and specificity in the detection of stenosed vessels were 75% and 88%. In infarcted areas (n=47), sensitivity and specificity in the detection of stenosed vessels were 98% and 80% (differences not significant vs noninfarcted areas).Conclusions
Adenosine-controlled coronary vasodilation combined with quantitative 99mTc-labeled MIBI tomography is accurate for identifying patients with CAD and localizing individual stenosed coronary arteries. 相似文献29.
Pasquale Sullo Alberto Cuocolo Emanuele Nicolai Stefania Cardei Antonio Nappi Fiorenzo Squame Eugenio M. Covelli Leonardo Pace Marco Salvatore 《European journal of nuclear medicine and molecular imaging》1996,23(6):648-655
The aim of this study was to evaluate the accuracy of quantitative 1-day exercise-rest technetium-99m tetrofosmin tomography in the identification of patients with coronary artery disease (CAD) and in the detection of individual stenosed coronary vessels. Sixty-one patients with suspected CAD who underwent coronary angiography and 13 normal volunteers were studied. All patients were submitted to two i.v. injections of99mTc-tetrofosmin, one at peak exercise (370 MBq) and the other (1110 MBq) at rest 3 h after exercise (images 15–30 min after injection for both studies). All patients with CAD (0% luminal stenosis) (n=50) had an abnormal99mTc-tetrofosmin tomogram. Only one patient without significant coronary narrowing showed abnormal findings. Overall sensitivity, specificity and diagnostic accuracy in the detection of individual stenosed vessels were 77%, 93% and 85%, respectively. Sensitivity and diagnostic accuracy in the identification of individuals stenosed coronary vessels were significantly higher (P<0.05) in patients with single-vessel disease (n=21) than in those with multivessel disease (n=29). Sensitivity, specificity and accuracy for detecting individual diseased vessels were similar in patients without previous myocardial infarction (n=26) and in those with previous myocardial infarction (n=35). In myocardial territories related to non-infarcted areas (n=128), sensitivity and specificity in the detection of stenosed vessels were 70% and 95%, respectively. In infarcted areas (n=55), sensitivity and specificity in the detection of stenosed vessels were 85% (P=NS vs non-infarcted areas) and 75% (P<0.05 vs non-infarcted areas), respectively. Finally, sensitivity was significantly lower (P<0.05) in vascular territories supplied by vessels with moderate stenosis (50%–75%) than in those supplied by vessels with severe stenosis (>75%). The results of this study demonstrate that quantitative 1-day exercise-rest99mTc-tetrofosmin single-photon emission tomographic imaging is a suitable and accurate technique to identify patients with CAD and to detect individual stenosed coronary vessels. 相似文献
30.
Analysis of the data from a carefully conducted multi-investigator study utilizing 261 subjects with a diagnosis of vulvovaginal candidiasis determined the cure rates in oral contraceptive users as compared to the cure rates in oral contraceptive non-users when treated with miconazole nitrate 2% Vaginal Cream (MONISTAT1). The criteria for a cure required that subjects have a negative KOH smear, negative NICKERSON'S Medium culture for species, and complete absence of the signs and symptoms of vulvovaginal candidiasis 30 or more days following the course of therapy. There was no significant difference in the cure rates of the oral contraceptive users when compared to the oral contraceptive non-users. It is concluded that there is no justification for routinely discontinuing oral contraceptive therapy during treatment for vulvovaginal candidiasis with miconazole nitrate 2% Vaginal Cream (MONISTAT). 相似文献