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Prodhan P Imamura M Garcia X Byrnes JW Bhutta AT Dyamenahalli U 《ASAIO journal (American Society for Artificial Internal Organs : 1992)》2012,58(2):143-147
The objective of this study was to investigate the effect of timely peritoneal dialysis (PD) catheter in children with abdominal compartment syndrome (ACS) while supported on extracorporeal membrane oxygenation (ECMO). We present a case series of four patients who developed significant intraperitoneal fluid accumulation and ACS at the general pediatric and cardiac intensive care units in a tertiary children's hospital. The hospital's ECMO database was queried for patients supported on ECMO who required PD catheter placement. These patients were assessed for clinical characteristics and outcomes. Four patients were identified with capillary leak syndrome associated with a primary diagnosis: cardiac transplant rejection in one, septic shock and acute respiratory distress syndrome in two, and neonatal hydrops fetalis in one patient. In each of these patients, a PD catheter was placed for severe abdominal distension and proven/suspected ACS. There was dramatic improvement in venous return after drainage of peritoneal fluid. Two patients were subsequently able to be separated successfully from ECMO support. One patient died of acute neurologic complication and the other because of severe gastrointestinal bleeding. After ruling out common causes for decreased venous return, ACS should be suspected as one of the important causes, especially in patients with massive capillary leak and increasing abdominal distension, among patients supported on ECMO. Timely placement of a PD catheter in patients who develop abdominal distension and ACS can substantially improve venous return and thus help maintain adequate tissue perfusion by improving ECMO flows. 相似文献
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Parthak Prodhan Sjirk J. Westra James Lin Sarit Karni-Sharoor Susan Regan Natan Noviski 《Pediatric radiology》2009,39(2):117-123
Background RSV-infected children demonstrate various radiographic features, some of which are associated with worse clinical outcomes.
Objective To investigate whether specific chest radiological patterns in RSV-infected children with acute respiratory failure (ARF)
in the peri-intubation period are associated with prolonged duration of mechanical ventilation.
Materials and methods We included RSV-infected children <1 year of age admitted with ARF from 1996 through 2002 to the pediatric intensive care
unit at Massachusetts General Hospital. Their chest radiographs were evaluated at three time-points: preintubation (day −1)
and days 1 and 2 after intubation. Univariate and multiple logistic regressions models were utilized to investigate our objective.
Results The study included 46 children. Using day 1 chest radiograph findings to predict duration of mechanical ventilation of >8 days,
a backward stepwise regression arrived at a model that included age and right and left lung atelectasis. Using day 2 chest
radiograph results, the best model included age and left lung atelectasis. A model combining the two days’ findings yielded
an area under the ROC curve of 0.92 with a satisfactory fit (P = 0.95).
Conclusion Chest radiological patterns around the time of intubation can identify children with RSV-associated ARF who would require
prolonged mechanical ventilation. 相似文献
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Parthak Prodhan Sarit Sharoor-Karni James Lin Natan Noviski 《The American journal of emergency medicine》2011,29(2):168-173
Background
Respiratory syncytial virus (RSV)-related disease is the leading cause of hospitalization among infants, with approximately 7% to 21% of these patients developing acute respiratory failure.Objective
The aim of this study was to identify clinical variables at initial presentation in the emergency department (ED) that may predict the subsequent need for mechanical ventilation among previously healthy, RSV-infected children who require pediatric intensive care unit (PICU) hospitalization.Study design
This is a retrospective study of 67 previously healthy, RSV-infected patients admitted from January 1997 to March 2000 to the PICU. The primary outcome for this study was the need for mechanical ventilation. The relationship between clinical variables at initial ED presentation and the need for mechanical ventilation were explored using univariate and multiple logistic regression analysis.Results
On multivariate analysis, the presence of lethargy (odds ratio [OR], 12.2; P = .005), grunting (OR, 9.3; P = .01), and a Paco2 65 mm Hg or greater (OR, 11.8; P = .013) were clinical factors at initial presentation in the ED associated with the subsequent need for mechanical ventilation among the study cohort. A developmental model that included lethargy, grunting, and a Paco2 of 65 mm Hg or greater performed well as a prediction model. The developmental model had a sensitivity of 71%, specificity of 96%, a positive predictive value of 86%, and a negative predictive value of 91%.Conclusions
The presence of lethargy, grunting, and a Paco2 of 65 mm Hg or greater at initial presentation in the ED were predictive for the subsequent need for mechanical ventilation in previously healthy, RSV-infected children admitted to the PICU. 相似文献24.
Prodhan P Dela Rosa RS Shubina M Haver KE Matthews BD Buck S Kacmarek RM Noviski NN 《Respiratory care》2008,53(10):1304-1309
OBJECTIVE: To correlate wheeze detection in the pediatric intensive care unit among staff members (a physician, nurses, and respiratory therapists [RTs]) and digital recordings from a computerized respiratory sound monitor (PulmoTrack). METHODS: We prospectively studied 11 patients in the pediatric intensive care unit. A physician, nurses, and RTs auscultated the patients and recorded their opinions about the presence of wheeze at baseline and then every hour for 6 hours. The clinician auscultated while the PulmoTrack recorded the lung sounds. The data were analyzed by a technician trained in interpretation of acoustic data and by a panel of experts blinded to the source of the recorded data, who scored all tracks for the presence or absence of wheeze. The degree of correlation among the expert panel, the staff, and the PulmoTrack was evaluated with the Kappa coefficient and McNemar's test. The determinations of the expert panel were taken as the true state (accepted standard). RESULTS: The PulmoTrack and expert panel were in agreement on detection of wheeze during inspiration, expiration, and the whole breath cycle; in all cases the Kappa coefficients were 0.54, 0.42, and 0.50 respectively. The PulmoTrack was significantly more sensitive than the physician (P = .002), nurses (P < .001), or RTs (P = .001). However, the specificity of the PulmoTrack was not significantly different from that of the physician, nurses, or RTs. CONCLUSIONS: Between the physician, RTs, and nurses there was agreement about the presence of wheeze in critically ill patients in the pediatric intensive care unit. Compared to the objective acoustic measurements from the PulmoTrack, the intensive care unit staff was similar in their ability to detect the absence of wheeze. The PulmoTrack was better than the staff in detecting wheeze. 相似文献
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Prodhan P Casavant D Medlock MD Yager P Kim J Noviski N 《Transplantation proceedings》2004,36(9):2570-2572
Many cadaveric organs for transplantation come from patients dying of sudden intracranial catastrophes. Cardiopulmonary dysfunction after such neurogenic insults is a well-recognized entity. The pulmonary dysfunction usually presents as florid pulmonary edema within minutes to hours after the initial intracranial insult and may occur in isolation or co-exist with overt or subclinical myocardial dysfunction. This may result in severe hypoxia, which threatens survival and outcomes in salvageable cases and organ preservation in patients who would be potential organ donors. Thus, rapid initiation of strategies aimed at ameliorating hypoxia after an acute neurogenic insult is paramount. Strategies aimed at improving acute hypoxia include maximizing ventilator support, diuretics, and volume resuscitation. Cardiac dysfunction may require use of ionotropes. We report the case of a 16-year-old female who developed catastrophic acute posterior fossa intracranial bleeding with resulting intractable hypoxia due to neurogenic cardiopulmonary dysfunction that responded dramatically to inhaled nitric oxide (INO). The patient went on to successfully donate organs following a non-heart-beating donor protocol. This therapy, to our knowledge, has never been described previously for use in patients with hypoxia secondary to neurogenic cardiopulmonary dysfunction. CONCLUSIONS: We document for the first time a dramatic response of hypoxia to INO in neurogenic cardiopulmonary dysfunction. This therapy ameliorates hypoxia, which may have vital implications in minimizing secondary brain injury in salvageable cases and optimizing organ preservation in potential organ donors with catastrophic intracranial insults. 相似文献
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