全文获取类型
收费全文 | 1770篇 |
免费 | 78篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 61篇 |
妇产科学 | 23篇 |
基础医学 | 296篇 |
口腔科学 | 40篇 |
临床医学 | 166篇 |
内科学 | 513篇 |
皮肤病学 | 32篇 |
神经病学 | 106篇 |
特种医学 | 26篇 |
外科学 | 225篇 |
综合类 | 9篇 |
预防医学 | 141篇 |
眼科学 | 26篇 |
药学 | 70篇 |
中国医学 | 1篇 |
肿瘤学 | 122篇 |
出版年
2023年 | 9篇 |
2022年 | 20篇 |
2021年 | 35篇 |
2020年 | 26篇 |
2019年 | 30篇 |
2018年 | 46篇 |
2017年 | 27篇 |
2016年 | 45篇 |
2015年 | 35篇 |
2014年 | 69篇 |
2013年 | 76篇 |
2012年 | 112篇 |
2011年 | 127篇 |
2010年 | 52篇 |
2009年 | 51篇 |
2008年 | 87篇 |
2007年 | 94篇 |
2006年 | 103篇 |
2005年 | 72篇 |
2004年 | 69篇 |
2003年 | 64篇 |
2002年 | 62篇 |
2001年 | 60篇 |
2000年 | 55篇 |
1999年 | 43篇 |
1998年 | 19篇 |
1997年 | 21篇 |
1996年 | 22篇 |
1995年 | 13篇 |
1994年 | 12篇 |
1993年 | 10篇 |
1992年 | 40篇 |
1991年 | 23篇 |
1990年 | 20篇 |
1989年 | 16篇 |
1988年 | 28篇 |
1987年 | 22篇 |
1986年 | 18篇 |
1985年 | 20篇 |
1984年 | 16篇 |
1983年 | 8篇 |
1979年 | 7篇 |
1977年 | 8篇 |
1976年 | 9篇 |
1975年 | 5篇 |
1974年 | 8篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1967年 | 4篇 |
1966年 | 5篇 |
排序方式: 共有1858条查询结果,搜索用时 15 毫秒
31.
32.
Marcello Fonseca Salgado‐Filho Samira Saady Morhy Henrique Doria de Vasconcelos Eric Benedet Lineburger Fabio de Vasconcelos Papa Eduardo Souza Leal Botelho Marcelo Ramalho Fernandes Maurício Daher David Le Bihan Chiara Scaglioni Tessmer Gatto Cláudio Henrique Fischer Alexander Alves da Silva Carlos Galhardo Júnior Carolina Baeta Neves Alexandre Fernandes Marcelo Luiz Campos Vieira 《Brazilian Journal of Anesthesiology》2018,68(1):1-32
Through the Life Cycle of Intraoperative Transesophageal Echocardiography (ETTI/SBA) the Brazilian Society of Anesthesiology, together with the Department of Cardiovascular Image of the Brazilian Society of Cardiology (DIC/SBC), createded a task force to standardize the use of intraoperative transesophageal echocardiography by Brazilian anesthesiologists and echocardiographers based on scientific evidence from the Society of Cardiovascular Anesthesiologists/American Society of Echocardiography (SCA/ASE) and the Brazilian Society of Cardiology. 相似文献
33.
34.
35.
Andrea Antonio Papa Emanuele Gallinoro Alberto Palladino Paolo Golino 《Acta myologica》2020,39(3):136
Dystrophinopathic cardiomyopathy (DCM) is an almost constant manifestation in Becker muscular dystrophy (BMD) patients significantly contributing to morbidity and mortality. The nearly complete replacement of the myocardium by fibrous and fatty connective tissue results in an irreversible cardiac failure, characterized by progressive reduction of the ejection fraction. According to PARADIGM-HF trial results, the European Society of Cardiology (ESC) guidelines recommend the use of sacubitril/valsartan in ambulatory patients with heart failure and reduced ejection fraction, who remain symptomatic despite an optimal medical therapy. To date, little is still known about the use of sacubitril/valsartan in DCM. We report the case of a patient with dystrophinopathic end stage dilated cardiomyopathy with reduced ejection fraction who successfully responded to sacubitril/valsartan treatment.Key words: dystrophinopathic cardiomyopathy, heart failure, sacubitril/valsartan, Becker muscular dystrophy 相似文献
36.
Fabrizio Tomai Achille Gaspardone Marco Papa Patrizio Polisca 《Catheterization and cardiovascular interventions》2002,55(1):97-99
We report a case of acute left ventricular failure after transcatheter closure of a single secundum atrial septal defect in a 68-year-old man with coronary artery disease. Just before the procedure, two coronary lesions had been treated with direct stenting. Transcatheter closure of atrial septal defects should always be deferred in ischemic heart disease patients who need percutaneous myocardial revascularization. 相似文献
37.
Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease 总被引:3,自引:0,他引:3
Danese S Sgambato A Papa A Scaldaferri F Pola R Sans M Lovecchio M Gasbarrini G Cittadini A Gasbarrini A 《The American journal of gastroenterology》2005,100(4):886-895
OBJECTIVES: Increased homocysteine contributes to the pathophysiology of several chronic inflammatory diseases. Whether homocysteine could participate in mucosal inflammation in inflammatory bowel disease (IBD) has not been explored yet. Our aims were to study the levels of plasma and mucosal homocysteine in IBD patients and to assess whether homocysteine can trigger an inflammatory reaction on human intestinal microvascular endothelial cells (HIMECs). METHODS: Homocysteine was measured in the plasma, mucosal biopsy, and lamina propria mononuclear cell (LPMC) supernatants from normal and IBD subjects. HIMEC were cultured in presence of homocysteine, TNF-alpha, or folic acid, alone or in combination. Expression of vascular cell adhesion molecule 1 (VCAM-1) and intercellular cell adhesion molecule 1 was measured by flow cytometry and monocyte chemoattractant protein-1 (MCP-1) production by ELISA. Phosphorylation of p38 and p42/44 was assessed by immunoblot in HIMEC extracts. T-cell- and monocyte-HIMEC adhesion assays were used to evaluate the impact of homocysteine on leukocyte adhesion to intestinal endothelial cells. RESULTS: Patients with IBD displayed significantly higher homocysteine plasma and mucosal levels than control subjects. IBD-derived LPMC released higher homocysteine than control-derived LPMC. Treatment of HIMEC with homocysteine, and synergistically with the combination of TNF-alpha and homocysteine, triggered HIMEC inflammation, resulting in VCAM-1 up-regulation, MCP-1 production, and p38 phosphorylation. These events lead to an increased capacity of HIMEC to adhere T- and monocyte cells and were blocked by folic acid treatment. CONCLUSIONS: Homocysteine is increased in both the mucosa and plasma of patients with Crohn's disease and ulcerative colitis and contributes to the inflammatory state of the mucosal IBD endothelium. Therefore, homocysteine could play a proinflammatory role in IBD, which can be efficiently targeted by folic acid supplementation. 相似文献
38.
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine 《Emerging infectious diseases》2015,21(2):242-250
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. 相似文献
39.
Rago Anna Papa Andrea Antonio Attena Emilio Parisi Valentina Golino Paolo Nigro Gerardo Russo Vincenzo 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(5):1003-1007
Cardiovascular Drugs and Therapy - The purpose of the present study was to compare the long-term effectiveness and safety of newly initiated anticoagulation with edoxaban (EDO) versus uninterrupted... 相似文献
40.
Barbieri M Rizzo MR Papa M Acampora R De Angelis L Olivieri F Marchegiani F Franceschi C Paolisso G 《Experimental gerontology》2005,40(7):599-604
The combined effect of Peroxisome proliferator-activated receptor gamma (PPARG) Pro/Ala and interleukin-6 G174C gene variants, was evaluated in 429 Caucasian subjects in order to determine whether subjects carrying both variants were at different risk for obesity. In particular, the combined contribution of these two variants (both independent and interaction effects) to the total variation of obesity-related factors was estimated. All subjects were genotyped for codon 12 Pro/Ala locus variability and for the interleukin-6-174 C/G promoter polymorphism. Subjects with the Ala variant had significantly lower BMI, insulin resistance, triglyceride levels than those without. Furthermore, subjects with Ala variant had significantly lower IL-6 levels (0.88 +/- 0.9 vs 1.61 +/- 2.25 pg/ml; p = 0.041). In contrast, the IL6-C variant was significantly associated with lower plasma IL-6 and with lower total cholesterol levels but was not significantly associated with any other obesity risk factors. Indeed, subjects carrying both PPARG and IL-6 gene variants, had a clearly more favourable profile of obesity related risk factors than subjects with one variant, having Ala+/C+ carriers lower BMI (22.8 +/- 2.3 vs 24.14 +/- 1.9; f = 5.31; p < 0.005), insulin resistance (1.49 +/- 0.70 vs 2.13 +/- 0.92; f = 4.342; p = 0.038) and triglyceride levels (79.15 +/- 32.9 vs 98 +/- 6.73 mg/dl; f = 3.120; p < 0.005). These findings suggest that the effect of the two genetic variants on 'obesity related' factors is additive. 相似文献