Über den Tonus der Muskeln

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原位肝移植的临床探讨

本文报告１１９例１３５次的位肝移植的临床试验。其术后早期肝植体功能障碍诊断至关重要。移植后中心问题是排斥反应。临床表现、实验参数、特殊检查和组织学检查等可客观地评价移植后肝功能障碍，并可排斥反应，提高移植后治疗效果。     

Urothelkarzinom Einfluss G-Protein-gekoppelter Rezeptoren auf die Zellmotilit?t und Zellproliferation Einfluss G-Protein-gekoppelter Rezeptoren auf die Zellmotilit?t und Zellproliferation

Zur Entwicklung neuer zellbiologischer Therapieans?tze haben wir die Expression und Signaltransduktion G-Protein-gekoppelter Rezeptoren, deren Aktivierung zu einer Stimulation der Zellmotilit?t führt, an Harnblasenkarzinomzellen untersucht. Die beiden Rezeptoragonisten Lysophosphatids?ure (LPA) und Thrombin führen zur Zunahme der Zellmotilit?t. Pertussistoxin (PTX) hemmt die LPA-induzierte Zellmotilit?t.     

MY4 expression on B-lymphocyte malignancies may be associated with a more adverse prognosis

We have noted what other preliminary reports have also described as a new specificity of the MY4 monoclonal antibody from Coulter Immunology which previously was designated to only have myelogenous CD14 specificity. The MY4 marker appears to characterize a subpopulation of some B-lymphocytic malignancies that are CD19, CD20, surface immunoglobulin as well as MY4 positive. The results occurred when other myelogenous markers such as CD11b, CD13 and CD33 were unreactive. Another monoclonal antibody marker of CD14 specificity, MO2, did not demonstrate a similar reactivity. Various other monoclonal antibodies of the same IgGI subclass as MY4 were also not reactive and thereby excludes non-specific adsorption as an explanation of the results. The six patients described in this report represented five non-Hodgkin's lymphoma cases and one chronic lymphocytic leukemia case. Fifteen B-lymphocytic leukemias and 30 other B-lymphocytic non-Hodgkin's lymphomas analysed during the same period were not MY4 positive. In reviewing the clinical course of the six patients compared to the general behavior of these types of malignancies and making a speculative generalization from the small group of cases, the MY4 antigen appeared to be expressed by low to intermediate grade B-lymphocytic malignancies of a type that were more rapidly progressive and/or had a greater tendency to undergo a transformation of their malignancy. Two of the three transformed cases were proceeded by chronic lymphocytic leukemia.