全文获取类型
收费全文 | 264篇 |
免费 | 10篇 |
国内免费 | 3篇 |
专业分类
儿科学 | 10篇 |
妇产科学 | 6篇 |
基础医学 | 20篇 |
口腔科学 | 5篇 |
临床医学 | 26篇 |
内科学 | 29篇 |
皮肤病学 | 6篇 |
神经病学 | 5篇 |
特种医学 | 37篇 |
外科学 | 73篇 |
综合类 | 33篇 |
预防医学 | 8篇 |
眼科学 | 1篇 |
药学 | 6篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 4篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 10篇 |
2013年 | 7篇 |
2012年 | 13篇 |
2011年 | 18篇 |
2010年 | 13篇 |
2009年 | 7篇 |
2008年 | 10篇 |
2007年 | 12篇 |
2006年 | 16篇 |
2005年 | 12篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 9篇 |
2001年 | 12篇 |
2000年 | 3篇 |
1999年 | 6篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 17篇 |
1995年 | 14篇 |
1994年 | 6篇 |
1993年 | 7篇 |
1992年 | 1篇 |
1991年 | 5篇 |
1989年 | 7篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有277条查询结果,搜索用时 484 毫秒
271.
Minimally invasive surgery for gastroesophageal reflux disease 总被引:3,自引:0,他引:3
Oelschlager BK Pellegrini CA 《Journal of laparoendoscopic & advanced surgical techniques. Part A》2001,11(6):341-349
Surgical treatment of gastroesophageal reflux disease (GERD) is indicated for patients with moderate to severe signs and symptoms or a need for increasing doses of antisecretory drugs. Long segment Barrett's metaplasia is another indication, especially in young patients. Preoperative evaluation differs somewhat depending on whether the patient's symptoms are typical or atypical of GERD. Laparoscopic fundoplication is described. Follow-up of as long as 8 years indicates that more than 90% of patients are satisfied with the results, although 14% are using antisecretory drugs regularly. Recurrent symptoms or dysphagia may indicate surgical failure, and medical therapy, esophageal dilatation, or surgery may be appropriate. Laparoscopic surgery in these patients takes longer than the original procedure but has many benefits if performed by an experienced surgeon. 相似文献
272.
Hyunki Kim Sharon L Samuel Guihua Zhai Samir Rana Marie Taylor Heidi R Umphrey Denise K Oelschlager Donald J Buchsbaum Kurt R Zinn 《Cancer biology & therapy》2014,15(8):1053-1060
TRA-8, a monoclonal antibody targeting death receptor, has demonstrated high therapeutic effect for triple negative breast cancer (TNBC) in preclinical models. Tamoxifen, the standard of care for ERα-positive breast cancer, induces apoptosis via ERβ, which commonly presents in TNBC cells. The current study investigates the combination effects of TRA-8 and tamoxifen for TNBC. In vitro assays were implemented with two ERβ-positive TNBC cell lines, SUM159 and 2LMP, and in vivo therapy studies were followed using orthotopic breast tumor mouse models. IC50 of tamoxifen for SUM159 and 2LMP were 29 μM and 38 μM, respectively. Synergy between TRA-8 (0–1000 ng/mL) and tamoxifen (20 μM) was observed for both the cell lines. Tamoxifen (400 mg/kg diet) markedly suppressed the growth of SUM159 tumors for 6 weeks after therapy initiation, but it did not induce antitumor effect for 2LMP tumors. TRA-8 (0.1 mg, weekly, i.p.) successfully arrested the growth of both SUM159 and 2LMP tumors during therapy, but an antagonistic effect was observed when tamoxifen was combined. TRA-8 uptake into tumors was not changed by tamoxifen treatment. Histological analysis confirmed that caspase-3 activation induced by TRA-8 was significantly decreased when tamoxifen was used in combination. In conclusion, our findings suggest that the combined use of TRA-8 and tamoxifen may cause antagonistic effects for TNBC patients. 相似文献
273.
Total knee arthroplasty is not the only available surgical option for arthritic knees. It varies according to patient''s age and severity of the disease. 105 arthritic knees were surgically treated at the Joint Replacement Centre of Army Hospital (R&R) in last 4 years. 77 knees were osteoarthritic and 28 were rheumatoid. 24 of these were treated by arthroscopic debridement, 7 underwent unicondylar knee replacement and 74 underwent total knee replacement using Freeman Samuelsun (F/S) or Low Contact Stress (LCS) implants. The indications, contraindications, results and complications of these procedures are discussed.KEY WORDS: Arthroscopic debridement knee, Knee arthroplasty, Osteoarthritis, Rheumatoid arthritis, Unicondylar knee replacement 相似文献
274.
Saurabh?KhandelwalEmail author Rebecca?Petersen Roger?Tatum Huseyin?Sinan Daniel?Aaronson Fernando?Mier Ana?V.?Martin Carlos?A.?Pellegrini Brant?K.?Oelschlager 《Journal of gastrointestinal surgery》2011,15(2):235-239
Introduction
Although patients with achalasia complain mainly of dysphagia, we have observed that they also have a high rate of respiratory problems. We hypothesized that the latter may be due to poor esophageal clearance leading to aspiration. This study examines the effect of Heller myotomy on these symptoms. 相似文献275.
BK Goyal Premansu Roy PM Bhat NK Das KG Paul BS Duggal 《Medical Journal Armed Forces India》2012,68(2):129-131
Background
Hysteroscopic surgery requires pre-operative cervical ripening to facilitate adequate dilatation of the cervix for insertion of operative hysteroscope. This study was conducted to compare the efficacy of intracervical misoprostol with vaginal misoprostol in achieving cervical ripening before operative hysteroscopy.Methods
In this randomised comparative study conducted at a tertiary care teaching hospital, 56 patients needing operative hysteroscopy were divided into two groups of 28 patients, one for intracervical misoprostol and the other for vaginal misoprostol. Four hundred microgram of misoprostol was inserted on the night before and in the morning of operative hysteroscopy intracervically in group I and vaginally in group II.Results
Primary outcome measure was number of patients achieving 7 mm preoperative dilatation of cervix. Largest Hegar dilator that could be passed into the uterine cavity past the internal optic sheath without resistance was noted in each case. Mean cervical dilatation prior to operative hysteroscopy was calculated. In addition, incidence of slipping of vulsellum and cervical laceration was also noted. Time to achieve full cervical dilatation was recorded. In 23/28 cases of group I and 5/28 in group II, size 7 Hegar dilator could be passed without effort. Mean cervical dilatation was 7.5 mm in group I and 5.7 mm in group II. Slipping of the vulsellum and cervical lacerations were seen in significantly less patients in group I. Mean time to achieve cervical dilatation to 10 mm was 43.39 seconds in group I and 103.96 seconds in group II (P<0.0001).Conclusion
Intracervical administration of misoprostol is an effective method of achieving cervical ripening for easy cervical dilatation up to 10 mm prior to operative hysteroscopy.Key Words: cervical ripening, intracervical administration, misoprostol, operative hysteroscopy 相似文献276.
Long-term outcomes confirm the superior efficacy of extended Heller myotomy with Toupet fundoplication for achalasia 总被引:1,自引:0,他引:1
Background The standard Heller myotomy (SM) for achalasia extends 1 to 2 cm on to the stomach. The authors perform an extended myotomy
(EM) (>3 cm) with the goal of reducing postoperative dysphagia. This study examines the long-term efficacy and durability
of EM compared with SM.
Methods Patients with achalasia who underwent a laparoscopic Heller myotomy were identified from a prospective database that includes
symptom evaluation and results of esophageal functional studies. From September 1994 to August 1998, the authors performed
SM with Dor fundoplication, and from September 1998 through 2003, they performed EM with Toupet fundoplication. In 2001, they
performed a telephone survey of all available patients. This was repeated in 2005 for the EM group. The survey included scales
of symptom frequency (0 [never], 1 [once per month], 2 [once per week], 3 [once per day], 4 [more than once per day]) and
severity (0 [no symptoms] to 10 [symptoms equal to preoperative state]) as well as the need to undergo postoperative intervention
for dysphagia.
Results For this study, 52 patients underwent SM with Dor fundoplication (median follow-up period, 46 ± 24 months), and 63 patients
underwent EM with Toupet fundoplication (median follow-up period, 45 ± 17 months. Postoperative dysphagia severity was significantly
better in the EM group (4.8 ± 2.3 vs 3.1 ± 2.6; p < 0.005). There was no significant difference in postoperative heartburn frequency, esophageal acid exposure, or lower esophageal
sphincter pressure. In the SM group, 9 patients (17%) required reintervention for dysphagia: 14 endoscopic interventions for
5 patients (10%) and reoperation for 4 patients. Three patients (5%) in the EM group required reintervention for dysphagia:
one endoscopic intervention each and no reoperations (p < 0.05). A total of 30 patients in the EM group were contacted in both 2001 (median follow-up period, 19 ± 11 months) and
2005 (median follow-up period, 63 ± 10 months). There was no significant change over time in dysphagia severity (2.6 ± 1.9
vs 3.7 ± 2.0; p = 0.19).
Conclusions For the treatment of achalasia, EM with Toupet fundoplication provides excellent durable dysphagia relief that is superior
to SM with Dor fundoplication. 相似文献
277.