Lipodystrophia centrifugalis abdominalis infantilis

We describe the first case of lipodystrophia centrifugalis abdominalis infantilis to occur outside Japan. A 7-year-old Chinese boy presented with the classical features, which include the early onset of localized depression of the skin of the abdomen, centrifugal progression of the skin lesion and an erythematous scaling advancing edge. The subcutaneous fat is decreased in the depressed areas.     

激光溶脂技术的临床应用

目的:探讨激光溶脂技术的临床应用方法和疗效。方法:2006年3月￣2006年6月对54例患者采用了激光溶脂技术进行局部减脂塑身,均来自保加医疗美容上海和香港两诊所门诊病人。术后随访3月,根据术者和患者的综合判断,评价该技术的疗效。结果:术后3周术区开始缩小,3月效果非常明显。18例仅行溶脂的病例无瘀血发生,2￣5天后完全消肿,皮肤柔软平整,无脂肪液化后囊肿形成。其余溶脂后再吸脂患者,皮肤平整,2月后恢复柔软。全部患者均未出现皮肤松弛现象。结论:激光溶脂技术是一种创伤小、恢复快、疗效好的减脂塑身方法。     

口腔黏膜细胞与膀胱黏膜下脱细胞基质复合物构建组织工程化尿道的实验研究

目的 探讨以兔口腔黏膜细胞与同种异体膀胱黏膜下脱细胞基质(BAMG)复合物构建组织工程化尿道的可行性.方法 新西兰雄性兔24只,距尿道外口2.0 cm剥离尿道黏膜(2.0 cm×0.8 cm)后,随机分实验组和对照组,每组12只.切取实验组兔口腔黏膜组织分离细胞,在有灭活的3T3细胞培养皿上进行培养扩增,将培养获得的第2代口腔黏膜细胞种植于BAMG(2.2 cm×1.0 cm)上,植入实验组兔尿道缺损区域;对照组单纯采用无细胞植入的BAMG修复尿道.分别于术后1、2、6个月观察动物排尿情况,行尿道造影,8 F尿管插管确定有无狭窄;随后处死实验兔,取修复段尿道黏膜组织行组织学检查.结果 细胞培养获得的口腔黏膜细胞形态均一,生长良好;组织形态学、扫描电镜观察见口腔黏膜细胞与BAMG具有良好的相容性.实验组兔术后1、2、6个月伤口愈合良好、排尿通畅,无尿瘘发生,组织学和尿道造影检查显示带细胞修复的尿道形态完整、清晰宽敞,无狭窄发生;术后6个月植入的口腔黏膜细胞仍然存在,并明显扩增.对照组兔则出现排尿困难、尿道狭窄,光镜下发现黏膜及黏膜下存在严重的炎症反应.结论 兔口腔黏膜细胞与同种异体BAMG复合后,可成功用于尿道缺损的修复,构建组织工程化尿道.     

Prevalence of Retrograde Accessory Pathway Conduction During Atrial Fibrillation

Retrograde Conduction in Atrial Fibrillation. Introduction : Although atrial fibrillation occurs frequently in patients with the preexcitation syndrome, its pathogenesis remains controversial. The purpose of this study was to test the hypothesis that retrograde conduction over the accessory pathway occurs during atrial fibrillation and can serve as an important source of new wavefronts in atrial fibrillation.
Methods and Results : Eight patients undergoing surgical division of their accessory path-way(s) were studied. A plaque electrode array containing 56 (7 × 8) bipolar electrodes (5-mm resolution) was placed epicardially at the AV junction over the accessory pathway and atrial fibrillation was electrically induced. Excluding one patient who had only preexcited QRS complexes during atrial fibrillation and another whose accessory pathway was outside the mapped region, 4 of the 6 patients studied showed retrograde conduction over the accessory pathway during atrial fibrillation (mean atrial cycle length 157 ± 59 msec). In these patients, 186 atrial wavefronts near the accessory pathway were analyzed. Among 67 wavefronts immediately following nonpreexcited QRS complexes, 17 originated from retrograde conduction. This constituted 9% (17/186) of total atrial wavefronts near the accessory pathway. Estimated atrial refractory period during atrial fibrillation ranged from 81 to 165 msec.
Conclusions : (1) In patients with the preexcitation syndrome and atrial fibrillation, retrograde conduction over the accessory pathway contributed up to 9% of total atrial wavefronts near the accessory pathway. (2) The presence of an excitable gap in human atrial fibrillation was suggested by atrial preexcitation during retrograde conduction.     

Does Helicobacter pylori infection affect gastric emptying in patients with functional dyspepsia?

The objectives of the study were first, to determine if gastric emptying was altered in patients with functional dyspepsia with and without Helicobacter pylori infection compared with normal healthy volunteers; and second, to determine if there were further alterations in gastric emptying when the infection was eradicated. Gastric emptying was measured using a ^99mtechnetium radiolabelled solid meal and gastric emptying time was measured as t_1/2, viz. time taken for half the radiolabelled meal to be emptied from the stomach. The mean gastric emptying time for H. pylori-positive patients (n= 20) was 56.4±24.8 min; H. pylori-negative patients (n= 19) 67.8±31.8 min; and normal controls (n= 20) 58.8 ± 18.8 min. No significant difference was obtained between the groups (ANOVA; P= 0.348). Thirteen of 18 H. pylori-positive patients successfully eradicated the infection following treatment with omeprazole 40 mg o.m. and amoxycillin 500 mg t.d.s. for 2 weeks. The mean difference in the gastric emptying time before and H. pylori eradication was 23.9 + 13.2 min (P= 0.556). There was no significant difference in the frequency of specific dyspeptic symptoms as well as the overall mean symptom score between the H. pylori-positive and -negative patients. Gastric emptying was not different between patients with functional dyspepsia and normal controls. Helicobacter pylori infection does not appear to affect gastric emptying in patients with functional dyspepsia.     

咬合引导的颌骨重建精确度分析及功能评价

目的: 探讨颌骨缺损重建术中移植骨定位的平面优先原则,确保新建的颌骨功能定位与咀嚼功能恢复,为临床治疗提供指导。 方法: 对60例颌骨缺损患者,通过数字化虚拟手术设计,确定平面的位置并以其作为参考平面,以咬合关系为引导,进行颌骨定位重建,最终完成种植修复。采集术后1个月和6个月时的CT数据,并与术前设计方案进行对比,分析移植骨就位和种植体植入的精确度,测定咬合力分布情况,进行功能评价。 结果: 术后1个月时,上颌骨移植腓骨和髂骨就位的精确度分别为(90.28±0.29)%和(89.87±0.41)%,下颌骨分别为(82.21±0.32)%和(89.52±0.18)%,上颌和下颌种植体的精确度分别为(91.72±0.21)%和(86.07±0.26)%。术后6个月时,上颌骨移植腓骨和髂骨就位的精确度分别为(89.24±0.20)%和(89.86±0.37)%,下颌骨分别为(75.39±0.25)%和(85.02±0.17)%,上颌和下颌种植体的精确度分别为(90.22±0.27)%和(85.57±0.31)%。单侧颌骨缺损的咬合力分布健侧为(68.14±8.32)%,患侧为(35.22±5.73)%;而双侧缺损的左、右两侧分别为(52.18±1.75)%和(47.82±2.41)%。 结论: 咬合引导的颌骨重建能够预先确定移植骨的空间位置、种植体的植入位点与方向,最终实现精准的咬合重建,恢复咀嚼功能,是颌骨功能性重建的有力保障。     

浅谈仪器性能验证中的携带污染率的检测

目的：初步探讨仪器性能验证中关于携带污染率有关内容。方法：以科美CC600化学发光分析仪及Stago STA全自动血凝仪为例,设定这两种仪器的携带污染率检测的方案,进行检测并分析其所得结果。结果：科美CC600化学发光分析仪、Stago STA全自动血凝仪的携带污染率的检测方案不同,但结果均符合仪器相关要求。结论：在携带污染率的检测中应根据仪器不同,选择适合的检测方案并合理分析其仪器的相关性能。     

血必净注射液治疗急性痛风性关节炎的临床观察

[目的] 观察血必净注射液治疗急性痛风性关节炎的临床疗效.[方法] 将60例急性痛风性关节炎患者随机分为对照组与治疗组,每组各30例,均予常规西医治疗,治疗组加用血必净注射液,治疗两周观察疗效,比较两组临床总有效率、C反应蛋白(CRP)及血尿酸(SUA)水平的变化.[结果] 治疗组临床总有效率为93%,对照组为73%,治疗组与对照组相比有统计学差异(P<0.05).[结论] 血必净注射液治疗急性痛风性关节炎疗效满意.     

口服结肠靶向给药系统的研究进展

口服结肠靶向给药系统在药物转运和治疗结肠局部疾病方面具有重要作用。本文总结了口服结肠靶向给药系统近年来的研究概况,并对结肠靶向药物制剂的体内、外评价方法作一介绍。