全文获取类型
收费全文 | 671篇 |
免费 | 89篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 39篇 |
妇产科学 | 10篇 |
基础医学 | 63篇 |
口腔科学 | 25篇 |
临床医学 | 123篇 |
内科学 | 170篇 |
皮肤病学 | 41篇 |
神经病学 | 17篇 |
特种医学 | 104篇 |
外科学 | 75篇 |
综合类 | 13篇 |
预防医学 | 26篇 |
眼科学 | 4篇 |
药学 | 14篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 8篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 15篇 |
2016年 | 24篇 |
2015年 | 18篇 |
2014年 | 31篇 |
2013年 | 29篇 |
2012年 | 13篇 |
2011年 | 17篇 |
2010年 | 30篇 |
2009年 | 50篇 |
2008年 | 15篇 |
2007年 | 13篇 |
2006年 | 24篇 |
2005年 | 17篇 |
2004年 | 16篇 |
2003年 | 13篇 |
2002年 | 7篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 13篇 |
1998年 | 33篇 |
1997年 | 35篇 |
1996年 | 38篇 |
1995年 | 29篇 |
1994年 | 25篇 |
1993年 | 32篇 |
1992年 | 6篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 18篇 |
1988年 | 13篇 |
1987年 | 21篇 |
1986年 | 14篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 10篇 |
1980年 | 5篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 8篇 |
1975年 | 3篇 |
1973年 | 2篇 |
1966年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有769条查询结果,搜索用时 0 毫秒
91.
92.
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry 总被引:8,自引:1,他引:8
Nistico L; Buzzetti R; Pritchard LE; Van der Auwera B; Giovannini C; Bosi E; Larrad MT; Rios MS; Chow CC; Cockram CS; Jacobs K; Mijovic C; Bain SC; Barnett AH; Vandewalle CL; Schuit F; Gorus FK; Tosi R; Pozzilli P; Todd JA 《Human molecular genetics》1996,5(7):1075-1080
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus
is determined by a combination of environmental and genetic factors, which
include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin
gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2
cannot explain the clustering of type 1 diabetes in families, and a role
for other genes is inferred. In the present report we describe linkage and
association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte
associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong
candidate gene for T cell- mediated autoimmune disease because it encodes a
T cell receptor that mediates T cell apoptosis and is a vital negative
regulator of T cell activation. In addition, we provide supporting evidence
that CTLA-4 is associated with susceptibility to Graves' disease, another
organ- specific autoimmune disease.
相似文献
93.
94.
S Caserío C Gallego P Martin MT Moral CR Pallás A Galindo 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(10):1571-1577
Aim: To analyse the main prenatal and postnatal features of congenital chylothorax (CC), and the outcome including mid‐term follow‐up. Methods: We searched our databases for CC diagnosed between 1990 and 2006. Data of 29 cases were retrieved and analysed. Follow‐up until 3 years of age was available for all patients. Results: Most patients were diagnosed prenatally (94%) and most cases were complicated by foetal hydrops (66.7%). The overall survival rate at 3 years was 56%. A significantly poorer outcome was observed when foetal hydrops, preterm birth < 34 weeks, large effusions and/or early‐onset pneumothorax were present. An important but not significant improvement in the survival rate was observed through the study period; while in 1990–1998, the survival rate was 41.7%, from 1999 to 2006 it was 66.7% (p = 0.19). In the mid‐term follow‐up, we did not observe any recurrence of CC and most infants remain asymptomatic. However, 27% of survivors were diagnosed as having asthma in early infancy. Conclusion: CC still carries a significant risk of perinatal mortality. However, continuous advances in foetal and neonatal medicine are improving the prognosis of these patients, and nowadays most of them are likely to survive. Beyond the neonatal period, most survivors have an uneventful outcome. 相似文献
95.
Chondromalacia patellae: assessment with MR imaging 总被引:10,自引:0,他引:10
Yulish BS; Montanez J; Goodfellow DB; Bryan PJ; Mulopulos GP; Modic MT 《Radiology》1987,164(3):763-766
Magnetic resonance (MR) images of the posterior patellar hyaline articular cartilage were obtained in 23 subjects to determine if MR imaging could accurately demonstrate the patellar cartilage. Arthroscopy was used as the standard of reference. Three subjects were asymptomatic volunteers. In the remaining 20 who had patellofemoral pain, arthroscopy was performed before MR imaging in seven and afterward in 12; one did not undergo arthroscopy. MR imaging showed focal areas of swelling of the patellar cartilage, focal hypointensity, surface irregularity, areas of thinning, and areas of cartilage loss with exposure of subchondral bone. The surgical findings agreed with those from MR images in all seven patients who underwent arthroscopy before MR imaging and in ten of the 12 who underwent surgery afterward. MR imaging is an accurate means of examining the posterior patellar cartilage and should be considered as an alternative to diagnostic arthroscopy when chondromalacia patellae is suspected. 相似文献
96.
97.
98.
Bangert BA; Modic MT; Ross JS; Obuchowski NA; Perl J; Ruggieri PM; Masaryk TJ 《Radiology》1995,195(2):437
99.
100.