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排序方式: 共有3876条查询结果,搜索用时 31 毫秒
61.
Overweight,obese, underweight,and frequency of sugar consumption as risk indicators for early childhood caries in Brazilian preschool children 下载免费PDF全文
Cecilia Claudia Costa Ribeiro Mariana Carvalho Batista da Silva Ana Margarida Melo Nunes Erika Bárbara de Abreu Fonseca Thomaz Cadidja Dayane Sousa Carmo Marizélia Rodrigues Costa Ribeiro Antônio Augusto Moura da Silva 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2017,27(6):532-539
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Fonseca Eduardo Kaiser Ururahy Nunes Sameshima Yoshino Tamaki 《Abdominal imaging》2018,43(12):3513-3514
Abdominal Radiology - 相似文献
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Lucas F Soveral Gabriela G Korczaguin Pedro S Schmidt Isabel S Nunes Camilo Fernandes Carlos R Z rate-Blad s 《World journal of gastroenterology : WJG》2022,28(33):4762-4772
Fecal microbiota transplantation (FMT) is a successful method for treating recurrent Clostridioides difficile (C. difficile) infection (rCDI) with around 90% efficacy. Due to the relative simplicity of this approach, it is being widely used and currently, thousands of patients have been treated with FMT worldwide. Nonetheless, the mechanisms underlying its effects are just beginning to be understood. Data indicate that FMT effectiveness is due to a combination of microbiological direct mechanisms against C. difficile, but also through indirect mechanisms including the production of microbiota-derived metabolites as secondary bile acids and short chain fatty acids. Moreover, the modulation of the strong inflammatory response triggered by C. difficile after FMT seems to rely on a pivotal role of regulatory T cells, which would be responsible for the reduction of several cells and soluble inflammatory mediators, ensuing normalization of the intestinal mucosal immune system. In this minireview, we analyze recent advances in these immunological aspects associated with the efficacy of FMT. 相似文献
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William Marciel de Souza Gustavo Olszanski Acrani Marilia Farignoli Romeiro Osvaldo Reis Júnior Aline Lavado Tolardo Amanda Araújo Serrão de Andrade João Lídio da Silva Gonçalves Vianez Júnior Daniele Barbosa de Almeida Medeiros Márcio Roberto Teixeira Nunes Luiz Tadeu Moraes Figueiredo 《Archives of virology》2016,161(8):2325-2328
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Isabel Guerreiro Andreia Nunes Joost M. Woltering Ana Casaca Ana Nóvoa Tania Vinagre Margaret E. Hunter Denis Duboule Moisés Mallo 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(26):10682-10686
Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thoracic region extends well into Hox10-expressing areas of the embryo, suggesting that these proteins are unable to block rib formation. Here, we show that this is not a result of the loss of rib-repressing properties by the snake proteins, but rather to a single base pair change in a Hox/Paired box (Pax)-responsive enhancer, which prevents the binding of Hox proteins. This polymorphism is also found in Paenungulata, such as elephants and manatees, which have extended rib cages. In vivo, this modified enhancer failed to respond to Hox10 activity, supporting its role in the extension of rib cages. In contrast, the enhancer could still interact with Hoxb6 and Pax3 to promote rib formation. These results suggest that a polymorphism in the Hox/Pax-responsive enhancer may have played a role in the evolution of the vertebrate spine by differently modulating its response to rib-suppressing and rib-promoting Hox proteins. 相似文献
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Fátima Karoline Araújo Alves Dultra Adna Conceição Barros Helenemarie Schaer‐Barbosa Andréia Leal Figueiredo Clarissa Araújo Silva Gurgel Eduardo Antônio Gonçalves Ramos Ana Maria da Silva Carvalho Jean Nunes dos Santos 《Journal of oral pathology & medicine》2012,41(1):47-53
J Oral Pathol Med (2012) 41 : 47–53 Objective: The aim of this study was to investigate the presence of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors. Methods: Twenty‐seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E‐cadherin. Results: A significant difference regarding the mean density of CD1a‐positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied (P = 0.001). No CD1a‐positive cells were detected in most cases (n = 5) of cystic adenoid carcinomas. CD1a‐positive cells were detected in one mucoepidermoid carcinoma case, and six low‐grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a‐positive cells between the three malignant tumors showed no significant difference (P = 0.127). No significant difference was observed in the presence of E‐cadherin between tumors (P = 0.73), but it was detected in 24 cases. Conclusions: The lack of CD1a‐positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E‐cadherin mediates cell adhesion in these tumors although we did not demonstrate significance. 相似文献
70.
Rodrigo Dias Nunes Flávia Duarte Schutz Jefferson Luiz Traebert 《The journal of maternal-fetal & neonatal medicine》2018,31(14):1900-1905
Purpose: Cerebral palsy is often associated with prematurity and magnesium sulfate (MgSO4) has been used as a neuroprotector, with favorable results. However, its mechanism of action has not been fully elucidated. This study aimed to evaluate the association between MgSO4 at the imminent premature delivery and neonatal hemodynamic effects.Materials and methods: A cross-sectional study involving 94 newborns (NB) between 24 and 32?weeks at a Brazilian hospital was performed. Bivariate analysis between the use or the non-use of MgSO4 and hemodynamic characteristics was performed, using the Chi-square test.Results: NB were evaluated between those who received MgSO4 (27.7) and those who did not (72.3%). Normal heart rate was verified in 62.8% of NB, normal respiratory rate in 70.2%, and normal temperature in 22.3%. Oxygen saturation higher or equal than 95% was evidenced in 85.1% of NB, normal hemoglucotest in 74.5%, and hemoglobin greater or equal than 16.4?g/dL in 30.9%. Non-invasive ventilation was performed in 48.9% of NB, while 51.1% were submitted to endotracheal ventilation. There was no significance relation detected between the use of MgSO4 and the hemodynamic characteristics.Conclusions: MgSO4 does not appear to influence hemodynamic factors as a cause of the neuroprotection in premature NB. 相似文献