凯西莱联用复方丹参注射液治疗酒精性肝病临床观察

目的探讨凯西莱联用复方丹参注射液治疗酒精性肝病(ALD)的临床效果。方法将160例ALD患者随机分为治疗组和对照组,每组80例,对患者治疗前后进行临床评估和检测肝功能、AFP、肝纤维化等指标变化情况。结果治疗组治疗28天后临床症状和体征除肝区疼痛明显改善外(P<0.05),其余症状与对照组比较差异无显著性(P>0.05);两组治疗后肝功能、肝纤维化四项及AFP均有明显改善,但治疗组A/G、AST以及肝纤维化四项指标改善程度均优于对照组(P<0.01)。无明显毒副作用。结论凯西莱能有效改善ALD患者的临床症状、体征及肝功能、AFP,联合应用复方丹参注射液疗效更佳,尤其是抗肝纤维化效果更为明显,且毒副作用少,具有临床应用价值。     

Extracts of Monascusus Purpureus beyond Statins——Profile of Efficacy and Safety of the Use of Extracts of Monascus Purpureus

Monascus purpureus is a fungus that has been tradi-tionally used in China for thousands of years to produce ricewine . Traditionally the fungus is used to ferment non-gluti-nous cooking of rice ,to produce a kind of famous red ricewine .Its main traditional indications consist of disordersdue to the accumulation of fats (nosologically linked withthe problems of stasis of circulation in traditional Chinesemedicine) ,liver disorders and some forms of tumor as ithelps i mprove the circulation of …     

Sexual precocity: sex incidence and aetiology

The aetiology of 197 girls and 16 boys presenting with sexual precocity was reviewed. Ninety one girls and four boys had central precocious puberty (M:F 23:1); a cause was identified in all the boys but in only six girls. All boys with precocious puberty need detailed investigation; in girls investigation should be based on clinical findings, particularly the consonance of puberty.     

显微注射后家兔转基因受精卵的体外培养和移植成活率的观察研究

目的：研究家兔受精卵经显微注射转基因过程的耐受性，建立转基因动物技术平台。方法：(1)家兔超数排卵诱导；(2)对2000个家兔受精卵进行显微注射技术操作；(3)对1280个受精卵进行显微注射后体外培养观察；(4)216个注射后受精卵向13只受体母兔输卵管进行移植．结果：(1)经显微注射后受精卵进行体外培养有68％的受精卵能够发育至桑椹胚和囊胚；(2)目前有7只受体母兔经输卵管转基因受精卵移植分别产下3，4，5，2，6，13，7只仔兔。结论：(1)受精卵能够在体外经受显微注射转基因过程的损伤，但暴露于体外的操作时间应尽可能的缩短；(2)显微注射操作技术的熟练程度是实验成功的关键。     

同种异体原位心脏移植术后心电图分析

目的：探讨同种异体原位心脏移植术后患者的心电图改变特点，方法：对3例心脏移植的患者术后分别进行体表12导联心电图跟踪观察，主要观察心率、心律、ST-T演变情况，结果：共同表现的ST段抬高系心肌再灌注后损伤性改变，不完全性右束支传导阻滞与手术中机械刺激或损伤有关，由于去神经作用心率变化较小，应用标准术式患者易出现心律失常，应用双腔静脉原位心脏移植术后心律失常发生率较少，结论：心脏移植术前、术后心电图追踪观察有助于指导治疗和评估预后。     

Effect of amniotic fluid cellular content on attic aeration pathways: histologic observations of infants aged 2 to 4 months

HYPOTHESIS: The tissue-fixed amniotic fluid cellular content (AFCC) in the middle ear and mastoid antrum causes foreign body type reactions that may later severely restrict the aeration pathways to the main attic and to Prussak's space. BACKGROUND: It was shown by Aschoff 100 years ago that AFCC remained in the neonate ears and caused sterile otitis media. Recent data show that children born through thick meconium are at risk for large quantities of AFCC entering the middle ear cleft, the ensuing inflammatory reaction being related to the amount of AFCC. Spread of AFCC in the neonate occurred along the aeration pathways with corresponding tissue fixation but further systematic data in young infants are lacking. METHODS: Five temporal bones of three infants aged 2 to 4 months were embedded in celloidin, serially sectioned at 20 microns, and every 10th section stained with Hematoxylin and eosin and mounted on slides. All slides were studied and relevant details of aeration pathways and all compartments photographed. RESULTS: The histologic changes were characterized by the development of masses of pseudocystic granulation tissue, with some remnants of the original AFCC, mainly in the form of fragments of hair. The tympanic isthmus was involved to varying extent, maximally to half of its size. Posterior tympanum and the stapes region had masses of fresh granulation tissue, the maturing of which might cause marked indrawing of the posterior pars tensa and further reduction of the tympanic isthmus. Aeration of Prussak's space was severely involved in two bones, favored by the narrow pathway through the posterior pouch. Features of recent acute or secretory otitis media were associated with the early changes caused by AFCC. CONCLUSIONS: The granulation tissue in this age group is immature and its final fate is decided by the nature of the future ear disease. If the AFCC contamination is slight, the granulation tissue after maturing may appear only in the form of thin cords and sheets, a frequent chance finding in ear surgery. Large amount of AFCC may lead to chronic inflammation, which may predispose the child to recurring middle ear infections during infancy. Further histologic and clinical studies in older infants and young children are needed to find out the final outcome after a massive AFCC contamination of the new-born middle ear.     

尿微量蛋白与老年2型糖尿病合并缺血性心脏病关系的研究

目的探讨在老年2型糖尿病合并缺血性心脏病患者中尿微量蛋白在加重缺血性心脏病进展方面的作用。方法将66例老年2型糖尿病合并缺血性心脏病患者按24h尿微量蛋白排泄量分为:尿微量蛋白正常组及尿微量蛋白阳性组,分别对血脂、空腹血糖、血清胰岛素、胰岛素敏感指数、纤维蛋白原、颈动脉内-中膜厚度、颈总动脉粥样硬化等级积分、硬化斑块指数、心脏彩超室间隔厚度及射血分数等加重缺血性心脏病进展等指标进行比较分析。结果66例老年2型糖尿病合并缺血性心脏病患者尿微量蛋白阳性组高密度脂蛋白、载脂蛋白A、胰岛素敏感指数、年龄、纤维蛋白原、硬化斑块指数、颈总动脉粥样硬化等级积分、室间隔厚度及射血分数显著高于尿微量蛋白阴性组(P<0.05,P<0.01)。结论尿微量蛋白的出现能够加速糖尿病合并缺血性心脏病的发展进程,它的出现预示着缺血性心脏病的预后不良。