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排序方式: 共有5195条查询结果,搜索用时 9 毫秒
81.
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Amirahmadi Roxana Sullivan Scott Britton Noel Siegel Ariel Spiegel Rory Miceli Jennifer Duong Vu Sholander Jeffrey T. Fontaine Magali J. McCurdy Michael T. 《Annals of hematology》2022,101(9):2045-2052
Annals of Hematology - Despite the low risk of peripherally inserted central catheter (PICC) insertion-related bleeding, the practice of administering prophylactic platelets varies greatly.... 相似文献
83.
Dr. M. Bouysset J. Tebib E. Noel C. Nemoz J. P. Larbre M. Bouvier 《Clinical rheumatology》1991,10(4):408-412
Summary Three hundred and eight unselected rheumatoid feet underwent a weight — bearing X-ray examination. If the malformations of the forefoot studied here present a statistical association, the primus metatarsus adductus is closely connected with tarsal arthritis and flattened foot but does not depend on the duration of the disease. The spread forefoot is indeed related to the duration of the disease and the presence of a metatarsal erosion at the foot level, but is not affected by the lesions of the midfoot. It appears then that an early orthopaedic treatment should be prescribed, once the first signs of involvement of the first ray or pronounced pronation of the hindfoot are noticed; it must affect the hindfoot, the midfoot and the first ray which progress together. 相似文献
84.
Patrizio Caturegli Noel R Rose Miho Kimura Hiroaki Kimura Shey-Cherng Tzou 《Thyroid》2003,13(5):419-426
The pathogenesis of autoimmune diseases is frequently studied in murine models, in which disease outcome is traditionally assessed by light microscopy. To determine whether digital imaging improves reliability of the histopathologic assessment, and whether flow cytometry is applicable directly on the murine thyroid, we studied 395 CBA/J mice 3 weeks after thyroglobulin immunization, and 192 nonimmunized CBA/J mice. Digital imaging significantly improved reliability of the histopathological assessment (r = 0.988, 95% confidence interval: 0.980-0.992, p < 0.0001), and flow cytometry on the murine thyroid could be performed successfully. We also found that normal thyroids contained a higher than expected number of hematopoietic cells in the interstitium. We suggest that digital imaging offers a better means of estimating disease outcome, and that flow cytometry performed at the target organ levels reflects the autoimmune pathogenesis more closely than when performed on peripheral lymphoid organs. These methods should also be applicable to other organ systems targeted by autoimmune attack, such as heart, exocrine, and other endocrine glands. 相似文献
85.
We sought to examine how patients’ treatment decisions incorporate potentially conflicting information from standard clinical indicators (e.g., tumor size) and genomic tests for breast cancer recurrence risk. Participants were 77 early stage breast cancer survivors who previously received genomic testing. They read six hypothetical vignettes that varied recurrence risk indicated by standard tests (low or high risk) coupled with the genomic test (low, intermediate or high risk). For each vignette, women reported their perceived recurrence risk and treatment preferences. Test results indicating high recurrence risk increased perception of risk and preference for chemotherapy (p < .001 for all). Perceived risk explained (i.e., mediated) the effect of test results on chemotherapy preferences. When test results conflicted, women gave more weight to genomic over standard test results. Hypothetical genomic test results had the intended effect of influencing women’s perceptions of recurrence risk and interest in chemotherapy. 相似文献
86.
Alison J. Cody Noel D. McCarthy Melissa Jansen van Rensburg Tomide Isinkaye Stephen D. Bentley Julian Parkhill Kate E. Dingle Ian C. J. W. Bowler Keith A. Jolley Martin C. J. Maiden 《Journal of clinical microbiology》2013,51(8):2526-2534
Sequence-based typing is essential for understanding the epidemiology of Campylobacter infections, a major worldwide cause of bacterial gastroenteritis. We demonstrate the practical and rapid exploitation of whole-genome sequencing to provide routine definitive characterization of Campylobacter jejuni and Campylobacter coli for clinical and public health purposes. Short-read data from 384 Campylobacter clinical isolates collected over 4 months in Oxford, United Kingdom, were assembled de novo. Contigs were deposited at the pubMLST.org/campylobacter website and automatically annotated for 1,667 loci. Typing and phylogenetic information was extracted and comparative analyses were performed for various subsets of loci, up to the level of the whole genome, using the Genome Comparator and Neighbor-net algorithms. The assembled sequences (for 379 isolates) were diverse and resembled collections from previous studies of human campylobacteriosis. Small subsets of very closely related isolates originated mainly from repeated sampling from the same patients and, in one case, likely laboratory contamination. Much of the within-patient variation occurred in phase-variable genes. Clinically and epidemiologically informative data can be extracted from whole-genome sequence data in real time with straightforward, publicly available tools. These analyses are highly scalable, are transparent, do not require closely related genome reference sequences, and provide improved resolution (i) among Campylobacter clonal complexes and (ii) between very closely related isolates. Additionally, these analyses rapidly differentiated unrelated isolates, allowing the detection of single-strain clusters. The approach is widely applicable to analyses of human bacterial pathogens in real time in clinical laboratories, with little specialist training required. 相似文献
87.
88.
Chih‐Yi Liu Andrey Bychkov Shipra Agarwal Yun Zhu Jen‐Fan Hang Chiung‐Ru Lai Hee Young Na Weiwei Li Zhiyan Liu Deepali Jain Ayana Suzuki Mitsuyoshi Hirokawa Noel Chia Min En Nga Tikamporn Jitpasutham Somboon Keelawat So Yeon Park Shinya Satoh Chien‐Chin Chen Dilini Gunawardena Priyanthi Kumarasinghe Chan Kwon Jung Kennichi Kakudo 《Diagnostic cytopathology》2021,49(1):60-69
89.
Noel C. Larson Steven D. Barger Sumner J. Sydeman 《International journal of behavioral medicine》2013,20(2):277-285