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Colegate-Stone T Raymond T Khot U Parker MC Stewart M 《Annals of the Royal College of Surgeons of England》2008,90(6):W3-W5
A case is reported in which endoscopic trans-anal rectal mucosal ablation (ETARMA) was employed in combination with laparoscopic partial proctectomy in order to decrease complications associated with open surgery. 相似文献
123.
Rita Ehrlich Nisha S. Kheradiya Diana M. Winston Daniel B. Moore Barbara Wirostko Alon Harris 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2009,247(5):583-591
Background The global society is aging at an increasing rate, with a continually larger proportion of the population consisting of those
over the age of 65. Age-related vascular changes have been demonstrated in ocular tissue, and the incidence and prevalence
of diseases such as macular degeneration, glaucoma and vascular occlusive diseases increase significantly with age.
Methods This article reviews the current body of literature examining age-associated ocular vascular changes, and summarizes the aggregate
findings. We discuss the potential role of the aging vasculature in the etiology of age-associated ocular disease, focusing
on glaucoma.
Results Our working hypothesis is that although advancing age is a physiological phenomenon, there are stepwise hemodynamic and vascular
changes that occur, predisposing the eye and other tissue beds to pathological conditions. Advancing age does not independently
give rise to disease, but does generate increasingly vulnerable vascular beds that are susceptible to further insults.
Conclusions These results compel a need for further investigation of age-related changes in ocular physiology and pathophysiology.
Funded in part by an unrestricted grant from Research to Prevent Blindness, New York, NY, USA. 相似文献
124.
Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients 总被引:1,自引:0,他引:1
Santiago G. Miriuka Loralie J. Langman Jovan Evrovski Steven E. S. Miner Nisha D''Mello Diego H. Delgado Betty Y. L. Wong Heather J. Ross David E. C. Cole 《Transplant international》2005,18(1):29-35
Genetic determinants for high homocysteine (Hcy) levels are now well known. We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls. At least one copy of the G allele of the MTRR A66G SNP was found in a significantly greater proportion of cardiac transplant (CTX) recipients compared with controls (94.0% vs. 79.9% respectively). None of the SNP analyzed were correlated with total Hcy plasma levels or the presence of transplant coronary artery disease. However, MS A2756G was significantly associated with cobalamin levels (AA genotype: 290 +/- 122 pmol/l; AG: 381 +/- 151 pmol/l and GG: 415 +/- 100 pmol/l), as was MTRR A66G (AA: 478 +/- 219 pmol/l, AG: 306 +/- 124 pmol/l and GG: 306 +/- 123 pmol/l). MTRR A66G was also correlated with serum folate. No association was found with thromboembolic events. In conclusion, there was a significant difference in the frequency of the G allele genotype of the MTRR A66G in CTX patients versus controls. Differences in cobalamin and folate levels with the MTRR A66G and MS A2756G polymorphisms were noted. Thus, SNP in Hcy-regulating genes may be important determinants of vitamin metabolism in CTX, raising the question of increased vitamin requirements to minimize increased plasma Hcy in this high-risk group. 相似文献
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Susana B Read Nisha V Kulprathipanja German G Gomez David B Paul Ken R Winston Joan M Robbins Carol A Kruse 《Journal of interferon & cytokine research》2003,23(7):379-393
By flow cytometry, a panel of 18 primary glioma cell explants exhibited high expression of class I HLA-A, B, C, but class II HLA-DR expression was absent. Freshly isolated normal brain cells displayed little or no HLA antigens. Alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the HLA of the patient, were generated in a one-way mixed lymphocyte response (MLR). The specificity of aCTL was confirmed to be to target cells (patient glioma cells or lymphoblasts) expressing the relevant HLA antigens. However, nontumor patient-specific aCTL did not lyse normal brain cells. Titration of antibodies to HLA class I into cytotoxicity assays blocked lysis of gliomas by aCTL, confirming aCTL T cell receptor (TCR) interactions with the class I antigen on gliomas. Furthermore, aCTL interactions with glioma cells caused their apoptosis. Coincubations of aCTL with gliomas resulted in upregulated cytokine secretion. Importantly, dexamethasone, an immunosuppressive steroid used for brain edema, did not affect aCTL lytic function against tumor, indicating that steroid-dependent patients may benefit from the immunotherapy. We also explored the use of interferon-gamma (IFN-gamma) to increase aCTL tumor recognition. Coincubation of gliomas with exogenous IFN-gamma (500 U/ml, 48 h) caused a 3-fold upregulation of HLA class I and a slight induction of class II antigen expression. Gene-modified glioma cells producing IFN-gamma similarly displayed upregulated HLA expression. Glioma cells incubated with exogenous IFN-gamma or IFN-gamma-transduced glioma cells were more susceptible to lysis by aCTL than their parental counterparts, thus supporting the concept of combining IFN-gamma cytokine gene therapy with adoptive aCTL immunotherapy for brain tumor treatment. 相似文献
127.
Efficacy of Glucose or Amino Acid–Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration 下载免费PDF全文
128.
Nisha M Kalyanasundaram M Paily KP Abidha Vanamail P Balaraman K 《Parasitology research》2007,100(3):575-579
Methanolic extracts of 20 medicinal plants were screened at 1–10 mg/ml for in vitro macrofilaricidal activity by worm motility
assay against adult Setaria digitata, the cattle filarial worm. Four plant extracts showed macrofilaricidal activity by worm motility at concentrations below
4 mg/ml and an incubation period of 100 min. Complete inhibition of worm motility and subsequent mortality was observed at
3, 2, 1 and 1 mg/ml, respectively, for Centratherum anthelminticum, Cedrus deodara, Sphaeranthus indicus and Ricinus communis. 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) reduction assay was carried out at 1 mg ml−1 and 4-h incubation period, and the results showed that C. deodara, R. communis, S. indicus and C. anthelminticum exhibited 86.56, 72.39, 61.20 and 43.15% inhibition respectively in formazan formation compared to the control.
This research is supported by The International Foundation for Science (IFS) and Organization for Prohibition of Chemical
Weapons (OPWC), Stockholm, Sweden through a Grant to Dr. Nisha Mathew (Grant No. F/2929-1). 相似文献
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