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991.
Karasu S Tokat AO Cetinkanat CG Karakaya J Cakmak H Aydin E Yazici U Gülhan E 《The Tohoku journal of experimental medicine》2012,226(2):145-150
Pneumothorax is the accumulation of air in the pleural space. Pneumothorax may occur spontaneously (primary spontaneous pneumothorax, PSP). Chest tube drainage (CTD) is the most common choice for treatment of PSP. This study aimed to evaluate patients treated with CTD, regarding demographic and diagnostic characteristics, and to compare the effectiveness of apical and axillary approaches. We retrospectively analyzed a total of 217 patients with PSP regarding symptoms, duration of complaints, and treatment procedures. There were 196 (90.3%) male patients and mean age was 25.22 ± 5.37 years. The approach of CTD was determined randomly; being performed with the apical approach on 93 (42.9%) and axillary on 124 patients (57.1%). There were no statistically significant differences between the two groups in terms of age, sex, BMI, collapse size, and complaint duration. However, a statistically significant relationship was determined between collapse size and leading symptoms where the significance was related to dyspnea (p < 0.001). This led to the thought that dyspnea increases with the increase of collapse size. The patients who were admitted to hospital in the later term when compared with others, had a larger collapse size (p < 0.001). This also led to the thought that collapse increases in relation to time due to late admission of patients. Hospitalization time was significantly shorter in patients who had apical CTD (p < 0.001). In conclusion, inserting the tube from the apex could shorten the treatment period. 相似文献
992.
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994.
Kamal AH Maguire JM Wheeler JL Currow DC Abernethy AP 《Journal of palliative medicine》2012,15(1):106-114
Although dyspnea is frequently encountered in the palliative care setting, its optimal management remains uncertain. Clinical approaches begin with accurate assessment, as delineated in part one of this two-part series. Comprehensive dyspnea assessment, which encompasses the physical, emotional, social, and spiritual aspects of this complex symptom, guide the clinician in choosing therapeutic approaches herein presented as part two. Global management of dyspnea is appropriate both as complementary to disease-targeted treatments that target the underlying etiology, and as the sole focus when the symptom has become intractable, disease is maximally treated, and goals of care shift to comfort and quality of life. In this setting, current evidence supports the use of oral or parenteral opioids as the mainstay of dyspnea management, and of inhaled furosemide and anxiolytics as adjuncts. Nonpharmacologic interventions such as acupuncture and pulmonary rehabilitation have potential effectiveness, although further research is needed, and use of a simple fan warrants consideration given its potential benefit and minimal burden and cost. 相似文献
995.
996.
Scheibe F Ladhoff J Huck J Grohmann M Blazej K Oersal A Baeva N Seifert M Priller J 《Journal of cerebral blood flow and metabolism》2012,32(8):1578-1588
Preclinical trials confirmed the potential of mesenchymal stromal cells (MSCs) to improve functional recovery after experimental stroke. Beneficial effects of MSCs are often attributed to their immunosuppressive/immunomodulatory functions. Surprisingly, the influence of MSCs on the immune system after stroke is poorly understood, but requires special consideration because cerebral ischemia is associated with stroke-induced immunodepression that predisposes to bacterial infections with increased mortality. In this study, we intravenously transplanted syngeneic murine bone marrow-derived MSCs (mMSCs) into C57BL/6 mice at 6 hours after transient middle cerebral artery occlusion (MCAo; 60 minutes) to investigate the impact of MSCs on stroke-induced immunodepression. Transplantation of syngeneic splenocytes or phosphate-buffered saline (PBS) served as controls. An immune status was determined by flow cytometry on days 3 and 14 after MCAo, which did not reveal any negative effects of cell transplantation on stroke-induced immunodepression. Although our mMSCs were found to exert immunosuppressive effects in vitro, stroke-mediated immune cell dysfunction was not altered by mMSCs in ex-vivo stimulation assays with lipopolysaccharide or concanavalin A. Moreover, systemic inflammatory cytokine levels (interleukin-6, tumor necrosis factorα, interferonγ, monocyte chemoattractant protein-1) remained unchanged in the sera of mice after cerebral ischemia and cell transplantation. These results reduce safety concerns about MSC administration in ongoing clinical stroke trials. 相似文献
997.
We describe a patient with idiopathic restless legs syndrome (iRLS) who was responsive to rasagiline treatment. A 70-year-old woman presented with an 8-year history of iRLS symptoms and a 1-year history of resting tremor. The patient met the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria (UK Parkinson Disease [PD] Brain Bank criteria) for the diagnosis of idiopathic PD and the criteria of the International Restless Legs Syndrome Study Group for the diagnosis of iRLS. One milligram of rasagiline once daily was started with the diagnosis of early PD as monotherapy. At week 8, the patient was almost iRLS symptoms free. Rasagiline has also been shown to mildly improve PD symptoms. Rasagiline was well tolerated during the follow-up. We suggest that rasagiline could represent a useful therapeutic option in the treatment of iRLS. 相似文献
998.
This paper presents automatic detection and localization of myocardial infarction (MI) using K-nearest neighbor (KNN) classifier.
Time domain features of each beat in the ECG signal such as T wave amplitude, Q wave and ST level deviation, which are indicative
of MI, are extracted from 12 leads ECG. Detection of MI aims to classify normal subjects without myocardial infarction and
subjects suffering from Myocardial Infarction. For further investigation, Localization of MI is done to specify the region
of infarction of the heart. Total 20,160 ECG beats from PTB database available on Physio-bank is used to investigate the performance
of extracted features with KNN classifier. In the case of MI detection, sensitivity and specificity of KNN is found to be
99.9% using half of the randomly selected beats as training set and rest of the beats for testing. Moreover, Arif-Fayyaz pruning
algorithm is used to prune the data which will reduce the storage requirement and computational cost of search. After pruning,
sensitivity and specificity are dropped to 97% and 99.6% respectively but training is reduced by 93%. Myocardial Infarction
beats are divided into ten classes based on the location of the infarction along with one class of normal subjects. Sensitivity
and Specificity of above 90% is achieved for all eleven classes with overall classification accuracy of 98.8%. Some of the
ECG beats are misclassified but interestingly these are misclassified to those classes whose location of infarction is near
to the true classes of the ECG beats. Pruning is done on the training set for eleven classes and training set is reduced by
70% and overall classification accuracy of 98.3% is achieved. The proposed method due to its simplicity and high accuracy
over the PTB database can be very helpful in correct diagnosis of MI in a practical scenario. 相似文献
999.
Sayar N Terzi S Yilmaz HY Atmaca H Kocak F Dayi SU Cakmak N Tarhan A Ozler A Yesilcimen K 《Heart and vessels》2006,21(5):331-333
Brucella endocarditis is a zoonosis transmitted by contaminated dairy products. Endocarditis is a rare complication of brucellosis
and mainly the aortic valve is infected. We present the case of a female patient with prosthetic mitral valve endocarditis
associated with QT prolongation and torsades de pointes. Transesophageal echocardiography revealed vegetation on both anterior
and posterior mitral annulus. She was seropositive with Brucella agglutination titers of up to 1/320. The QT interval was markedly prolonged upon admission (QTc 530 ms). She experienced
torsades de pointes several times. She underwent reoperation under an appropriate antibiotic regimen. She continued on triple
antibiotic therapy for 12 months. She is now well and free of symptoms. 相似文献
1000.