Therapeutic-preventive effect of sodium selenite on the course of experimental myocardial infarct]

An occlusion of the left coronary artery in rats tends to signally raise the intensity of free radical oxidation of myocardial-lipids, which is revealed by the chemofluorescent method. A direct correlational link between the intensity of the lipids peroxidation and the extent of the myocardial damage was established. Subcutaneous injection of sodium selenite in a dose of 30 gamma/kg 2 hours prior to ligation and once daily for a space of 7 days produces a distincly reduced intensity of free-radical processes in the myocardium, decreases the extent of infarction and prevents the appearance of gross changes on the ECG.     

The autoimmune process in acute radiation sickness and the effect of antibiotics on its development

Summary Materials are presented on the formation of autoantibodies during irradiation of rabbits in a dose of 600 R and the influence produced on their titer by antibiotics (penicillin, streptomycin, oxytetracycline, chloramphenicol).Methods are described for the detection of autoantibodies by means of sedimenting the antigen-antibody complex with subsequent nephelometry. Autoantibodies to the liver, spleen, kidney, lymphatic glands, aorta, heart, large and small intestine were determined.It has been found that in rabbits, on the second day after their exposure to ionizing radiation, there form auto-antibodies, whose titer increases with the progression of radiation sickness.Antibiotics inhibit the development of the autoimmune process.(Presented by Active Member of the Academy of Medical Sciences of the USSR V. V. Parin). Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 62, No. 10, pp. 38–41, October, 1966.