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991.
Uta M. Demel Marlitt Bger Schayan Yousefian Corinna Grunert Le Zhang Paul W. Hotz Adrian Gottschlich Hazal Kse Konstandina Isaakidis Dominik Vonficht Florian Grünschlger Elena Rohleder Kristina Wagner Judith Dnig Veronika Igl Bernadette Brzezicha Francis Baumgartner Stefan Habringer Jens Lber Bjrn Chapuy Carl Weidinger Sebastian Kobold Simon Haas Antonia B. Busse Stefan Müller Matthias Wirth Markus Schick Ulrich Keller 《The Journal of clinical investigation》2022,132(9)
992.
Niggemeyer Heinz Dubrauszky Viktor 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1953,120(6):627-650
Research in Experimental Medicine - Bisher bekannte Anschauungen über die Pathogenese metadiphtherischer Erkrankungen werden besprochen. In Tierversuchen wird festgestellt: Ein von uns... 相似文献
993.
AbstractApoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal on apoptotic cells which antagonises Toll-like receptor (TLR) signalling, we examined whether the tolerogenic capacity of Anx can be exploited to downregulate antigen-specific immune responses. The treatment of bone marrow-derived dendritic cells (BMDC) with particles harbouring Anx as well as the model antigen ovalbumin (OVA) attenuated the response of OVA-specific OT-II T cells. The co-culture of Anx-particle-treated DC and T cells resulted in an anergy-like phenotype characterized by reduced proliferation and cytokine secretion. Here we demonstrate that the anti-inflammatory effects of Anx which are mediated through DC can be used as a tool to generate a particle-based antigen delivery system that promotes antigen-specific immunosuppression. Such Anx-particles may be a new therapeutic approach for the treatment of autoimmune diseases. 相似文献
994.
Udo Buchholz Franziska Reber Ann-Sophie Lehfeld Bonita Brodhun Walter Haas Benedikt Schaefer Fabian Stemmler Christina Otto Corinna Gagell Christian Lück Ronny Gamradt Maxi Heinig Christian Meisel Uwe Kölsch Martin Eisenblätter Heiko J. Jahn 《International journal of hygiene and environmental health》2019,222(2):315-318
In Germany community-acquired Legionnaires' disease is usually caused by the species Legionella pneumophila. Recurrent cases of Legionnaires' disease are rarely reported and are due either to a second infection (reinfection) or a relapse of a previous case. We report a case of recurrent Legionnaires' disease in an 86-year-old female patient infected with Legionella pneumophila serogroup 1, monoclonal antibody-subtype Knoxville, sequence type unknown. Between the two disease incidents the patient had completely recovered. Legionella pneumophila was detected with the monoclonal antibody-subtype Knoxville, sequence type 182, in the drinking water of the patient's apartment. Exposure to contaminated drinking water was interrupted after the first incident exposure through the application of point-of-use water filters. The filters were later removed due to low water pressure, and the second illness occurred thereafter. It is unclear if immunological predisposition has contributed to this case of probable reinfection of Legionnaires' disease. Clinical, microbiological and epidemiological information combined suggest this is a case of reinfection of Legionnaires' disease. In cases of recurrent Legionnaires' disease complete collection of patient and water samples is necessary to differentiate relapse from reinfection cases, to implicate the source of infection and to gain more evidence for the role of immunological predisposition. 相似文献
995.
996.
Cellularity,characteristics of hematopoietic parameters and prognosis in myelodysplastic syndromes 下载免费PDF全文
997.
For patients with AIDS receiving antiretroviral treatment (ART) in South Africa via public clinics, improvements in nutritional status and economic productivity are likely to depend on adherence to drug regimen and quality of diet reflected in protein and micronutrient intakes. This study randomized 643 patients receiving ART from public clinics in the Free State Province into a Control group, a treatment group receiving adherence support, and a treatment group receiving adherence support and a nutritious food supplement. The data on food insecurity levels and time spent on various activities were analyzed for assessing the impact of the intervention programs. The main results were, first, changes between survey rounds 1 and 3 were significant at the 5% level for outcomes such as food insecurity levels and CD4 cell counts. Moreover, there was a significant reduction in food insecurity levels of patients with BMI less than 25 who received the nutritious food supplement. Second, the estimated parameters from models for patients’ food insecurity levels showed that household incomes were significantly associated with lower food insecurity levels. Third, patients’ BMI was a significant predictor of time spent on sedentary, moderate and overall activity levels, and it was important to separately evaluate the effects of BMI for under-weight and over-weight patients. Overall, the results indicated the need for reducing food insecurity levels, and for designing different interventions for under-weight and over-weight patients with AIDS for enhancing their labor productivity. 相似文献
998.
Household food security impacts heavily on quality of life. We determined factors associated with food insecurity in 886 households in rural and urban Free State Province, South Africa. Significantly more urban than rural households reported current food shortage (81% and 47%, respectively). Predictors of food security included vegetable production in rural areas and keeping food for future use in urban households. Microwave oven ownership was negatively associated with food insecurity in urban households and using a primus or paraffin stove positively associated with food insecurity in rural households. Interventions to improve food availability and access should be emphasized. 相似文献
999.
Martina Kluth Ramin Ahrary Claudia Hube-Magg Malik Ahmed Heinke Volta Catina Schwemin Stefan Steurer Corinna Wittmer Waldemar Wilczak Eike Burandt Till Krech Meike Adam Uwe Michl Hans Heinzer Georg Salomon Markus Graefen Christina Koop Sarah Minner Ronald Simon Guido Sauter Thorsten Schlomm 《Oncotarget》2015,6(29):27966-27979
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical consequences of this alteration have not been studied in detail. Dual labeling fluorescence in situ hybridization using probes for 12p13 (CDKN1B; p27) and centromere 12 as a reference was used to successfully analyze more than 3700 prostate cancers with clinical follow-up data assembled in a tissue microarray format. CDKN1B was selected as a probe because it is located in the center of the deletion, which spans > 10 Mb and includes > 50 genes in 80% of cancers with 12p deletion. Deletion of 12p was found in 13.7% of cancers and included 13.5% heterozygous and 0.2% homozygous deletions. 12p deletion were linked to advanced tumor stage (p < 0.0001), high Gleason grade (p < 0.0001), rapid tumor cell proliferation (p < 0.0001), lymph node metastasis (p = 0.0004), and biochemical recurrence (p = 0.0027). Multivariate analysis including pT stage (p < 0.0001), Gleason grade (p < 0.0001), pN status (p = 0.0001), preoperative PSA levels (p = 0.0001), and resection margin status (p = 0.0001) revealed an independent prognostic value of 12p deletion (p = 0.0014). Deletion of 12p was unrelated to the ERG fusion status. Deletion of 12p was only marginally linked to reduced p27 expression, which by itself was unrelated to clinical outcome. This argues against p27 as the key target gene of 12p deletions. In summary, the results of our study demonstrate that 12p deletion is frequent in prostate cancer and provides independent prognostic information. 12p deletion analysis alone, or in combination with other prognostic parameters may thus have clinical utility. 相似文献
1000.