A 308-nm monochromatic excimer light in the treatment of palmoplantar psoriasis

BACKGROUND: Various reports have shown the efficacy of narrow-band UVB (311-313 nm) and excimer laser (308 nm) in the treatment of psoriasis. OBJECTIVE: To prove the efficacy of light produced by xenon-chloride excimer at 308 nm (monochromatic excimer light, MEL) in the treatment of palmoplantar psoriasis (PP). METHODS: Fifty-four patients (29 male and 25 female) affected by PP were treated with MEL every 7-14 days. A mean number of 10 sessions was performed with an increase of the dose depending on patient's skin type and response. RESULTS: All 54 patients completed the treatment. After 4 months of MEL we observed a complete remission in 31 patients, a partial remission in 13 patients, and a moderate improvement in 10 patients. CONCLUSIONS: These results suggest that MEL can be considered as a valid therapeutic option for treatment of selected forms of PP.     

交流示波极谱滴定法测定盐酸环丙沙星及其制剂的含量

目的：采用交流示波极谱滴定法测定了盐酸环丙沙星及其制剂的含量。方法：在ｐＨ５．０－５．５的醋酸－醋酸钠缓冲液溶液中，环丙沙星与四苯硼钠定量反应形成１：１沉淀。过量的四苯硼钠用醋酸亚铊标准溶液回滴至示波极谱图上四苯硼钠切口消失。结果：该法平均回收率为９９．１８％，ＲＳＤ为０．４９％。结论：本法简便，快速，结果准确，可靠。     

In vitro dissolution of gallstones with MTBE: correlation with characteristics at CT and MR imaging

The authors undertook a study to determine whether in vitro computed tomography (CT) or magnetic resonance (MR) imaging could enable the prediction of the outcome of gallstone dissolution with methyl tert-butyl ether (MTBE). In vitro CT and MR images were obtained of gallstones removed at surgery from 40 and 30 patients, respectively. The patterns of the gallstones seen on CT scans were categorized as dense, moderately dense, faint, isodense, rimmed, and laminated. Gallstones were categorized by maximal signal intensities seen on T1-weighted MR images. After imaging, gallstones underwent in vitro MTBE dissolution. CT appearances correlated well with dissolution rates. Greatest weight change was noted in gallstones with homogeneously faint and isodense patterns, and least weight change was seen in stones with a homogeneously dense pattern. Rimmed and laminated stones with foci of high attenuation dissolved significantly to 5% or less of the original weight, a finding indicating that such foci do not preclude dissolution. Dissolution rates correlated with attenuation values of homogeneous stones (r = .8) and of the rim portion of rimmed stones (r = .8). No correlation was found between T1-weighted signal intensities on MR images and MTBE dissolution rates.     

抗癌及癌化学预防药物的研究:3-α-酮醛香豆素衍生物的合成及其抗致突活性与结构间的关系

α-酮醛及其衍生物在抗病毒、抗肿瘤方面有一定活性。我们合成了18个新的3-α-酮醛香豆素衍生物,研究该类化合物的质谱裂解方式与氢核磁共振谱的特征峰。体外药理筛选发现其中部分化合物有不同程度的抗致突活性,对其构效关系进行了分析,并提出了这类化合物产生抗致突活性的可能亚结构。     

睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究

睾丸酮、雌二醇和棉酚合并用药的雄性抗生育作用及其安全性的研究叶惟三，但凌，郭燕，钱晓菁，应骏，薛社普（中国医学科学院，中国协和医科大学基础医学研究所，北京１００００５）减轻有抗男性生育活性棉酚的副作用是发展棉酚成为男性避孕药急待解决的问题［１，２］。...     

Educational levels of hospital nurses and surgical patient mortality

CONTEXT: Growing evidence suggests that nurse staffing affects the quality of care in hospitals, but little is known about whether the educational composition of registered nurses (RNs) in hospitals is related to patient outcomes. OBJECTIVE: To examine whether the proportion of hospital RNs educated at the baccalaureate level or higher is associated with risk-adjusted mortality and failure to rescue (deaths in surgical patients with serious complications). DESIGN, SETTING, AND POPULATION: Cross-sectional analyses of outcomes data for 232 342 general, orthopedic, and vascular surgery patients discharged from 168 nonfederal adult general Pennsylvania hospitals between April 1, 1998, and November 30, 1999, linked to administrative and survey data providing information on educational composition, staffing, and other characteristics. MAIN OUTCOME MEASURES: Risk-adjusted patient mortality and failure to rescue within 30 days of admission associated with nurse educational level. RESULTS: The proportion of hospital RNs holding a bachelor's degree or higher ranged from 0% to 77% across the hospitals. After adjusting for patient characteristics and hospital structural characteristics (size, teaching status, level of technology), as well as for nurse staffing, nurse experience, and whether the patient's surgeon was board certified, a 10% increase in the proportion of nurses holding a bachelor's degree was associated with a 5% decrease in both the likelihood of patients dying within 30 days of admission and the odds of failure to rescue (odds ratio, 0.95; 95% confidence interval, 0.91-0.99 in both cases). CONCLUSION: In hospitals with higher proportions of nurses educated at the baccalaureate level or higher, surgical patients experienced lower mortality and failure-to-rescue rates.