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991.
Anette Schrag MD PhD Annika Spottke MD Niall Patrick Quinn MD FRCP Richard Dodel MD MPH 《Movement disorders》2009,24(6):813-818
The objective of the study is to examine the comparative responsiveness of outcome measures to assess progression over time in Parkinson's disease (PD). One hundred twenty‐eight patients participating in a clinic‐based naturalistic study of PD were assessed with the Hoehn and Yahr, UPDRS, MMSE, PDQ‐39, PDQL, EQ‐5D, and BDI scales at baseline and at 1 year. In addition, 82 patients in a community‐based study of patients with PD who had completed self‐rated Schwab and England, PDQ‐39, EQ‐5D, and BDI scales at baseline, were sent the same questionnaires at 1 and 4 years. Responsiveness was assessed using t‐tests, standardised effect size, and standardised response mean. In both samples, the Hr‐QoL measures were less responsive to change over time than the impairment and disability scales (Hoehn and Yahr, UPDRS, Schwab and England scales). In addition, in the clinic‐based sample, Hoehn and Yahr and UPDRS ADL scale (“on”) were more responsive to progression over time than UPDRS motor part and ADL part (“off”). Hr‐QoL measures are less responsive to change over time than measures of impairment and disability. Although this suggests that these measures are less accurate in detecting subtle changes, it may also indicate that the multifactorial subjective assessment of Hr‐QoL adapts to changes over time. Global assessment of overall impairment and disability (which incorporates motor and nonmotor features of PD), however, appeared relatively responsive to change over time in patients in a naturalistic setting. © 2009 Movement Disorder Society 相似文献
992.
Carole A. Ridge Ronan P. Killeen Katherine M. Sheehan Ronan Ryan Niall Mulligan David Luke Martin Quinn Jonathan D. Dodd 《Clinical imaging》2010,34(3):231-233
A 53-year-old woman presented to the emergency department with a 2-week history of dyspnoea and chest pain. Computed tomography pulmonary angiography was performed to exclude acute pulmonary embolism (PE). This demonstrated a large right atrial mass and no evidence of PE. Transthoracic echocardiography followed by cardiac magnetic resonance imaging confirmed a mobile right atrial mass. Surgical resection was then performed confirming a giant right atrial myxoma. We describe the typical clinical, radiologic, and pathologic features of right atrial myxoma. 相似文献
993.
Daniel V T Catenacci Niall C Tebbutt Irina Davidenko André M Murad Salah-Eddin Al-Batran David H Ilson Sergei Tjulandin Evengy Gotovkin Boguslawa Karaszewska Igor Bondarenko Mohamedtaki A Tejani Anghel A Udrea Mustapha Tehfe Ferdinando De Vita Cheryl Turkington Rui Tang Agnes Ang Yilong Zhang David Cunningham 《The lancet oncology》2017,18(11):1467-1482
994.
Niall P McGoldrick Joseph S Butler Maire Lavelle Stephen Sheehan Sean Dudeney Gary C O Toole 《World journal of orthopedics》2016,7(5):293-300
Soft tissue sarcoma accounts for approximately 1% of all cancers diagnosed annually in the United States. When these rare malignant mesodermal tumours arise in the pelvis and extremities, they may potentially encase or invade large calibre vascular structures. This presents a major challenge in terms of safe excision while also leaving acceptable surgical margins. In recent times, the trend has been towards limb salvage with vascular reconstruction in preference to amputation. Newer orthopaedic and vascular reconstructive techniques including both synthetic and autogenous graft reconstruction have made complex limb-salvage surgery feasible. Despite this, limb-salvage surgery with concomitant vascular reconstruction remains associated with higher rates of post-operative complications including infection and amputation. In this review we describe the initial presentation and investigation of patients presenting with soft tissue sarcomas in the pelvis and extremities, which involve vascular structures. We further discuss the key surgical reconstructive principles and techniques available for the management of these complex tumours, drawn from our institution's experience as a national tertiary referral sarcoma service. 相似文献
995.
Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis: Results From a Canadian Oral Health Study 下载免费PDF全文
Murray Baron Marie Hudson Marie Dagenais David Macdonald Geneviève Gyger Tarek El Sayegh Janet Pope Audrey Fontaine Ariel Masetto Debora Matthews Evelyn Sutton Norman Thie Niall Jones Maria Copete Dean Kolbinson Getulio Nogueira‐Filho David Robinson Marvin Fritzler Mianbo Wang Mervyn Gornitsky 《Arthritis care & research》2016,68(5):673-680
996.
997.
Niall Emmart Yang Chen & Charles C. Weems 《Communications In Computational Physics》2015,18(1):104-124
This paper presents a parallel algorithm for finding the smallest eigenvalue
of a family of Hankel matrices that are ill-conditioned. Such matrices arise in random
matrix theory and require the use of extremely high precision arithmetic. Surprisingly,
we find that a group of commonly-used approaches that are designed for high
efficiency are actually less efficient than a direct approach for this class of matrices.
We then develop a parallel implementation of the algorithm that takes into account
the unusually high cost of individual arithmetic operations. Our approach combines
message passing and shared memory, achieving near-perfect scalability and high tolerance
for network latency. We are thus able to find solutions for much larger matrices
than previously possible, with the potential for extending this work to systems with
greater levels of parallelism. The contributions of this work are in three areas: determination
that a direct algorithm based on the secant method is more effective when
extreme fixed-point precision is required than the algorithms more typically used
in parallel floating-point computations; the particular mix of optimizations required
for extreme precision large matrix operations on a modern multi-core cluster, and the
numerical results themselves. 相似文献
998.
Marta?Pinto-GrauEmail authorView authors OrcID profile Emmet?Costello Sarah?O’Connor Marwa?Elamin Tom?Burke Mark?Heverin Niall?Pender Orla?Hardiman 《Journal of neurology》2017,264(7):1397-1401
The Beaumont Behavioural Inventory (BBI) is a behavioural proxy report for the assessment of behavioural changes in ALS. This tool has been validated against the FrSBe, a non-ALS-specific behavioural assessment, and further comparison of the BBI against a disease-specific tool was considered. This study cross-validates the BBI against the ALS-FTD-Q. Sixty ALS patients, 8% also meeting criteria for FTD, were recruited. All patients were evaluated using the BBI and the ALS-FTD-Q, completed by a carer. Correlational analysis was performed to assess construct validity. Precision, sensitivity, specificity, and overall accuracy of the BBI when compared to the ALS-FTD-Q, were obtained. The mean score of the whole sample on the BBI was 11.45 ± 13.06. ALS-FTD patients scored significantly higher than non-demented ALS patients (31.6 ± 14.64, 9.62 ± 11.38; p < 0.0001). A significant large positive correlation between the BBI and the ALS-FTD-Q was observed (r = 0.807, p < 0.0001), and no significant correlations between the BBI and other clinical/demographic characteristics indicate good convergent and discriminant validity, respectively. 72% of overall concordance was observed. Precision, sensitivity, and specificity for the classification of severely impaired patients were adequate. However, lower concordance in the classification of mild behavioural changes was observed, with higher sensitivity using the BBI, most likely secondary to BBI items which endorsed behavioural aspects not measured by the ALS-FTD-Q. Good construct validity has been further confirmed when the BBI is compared to an ALS-specific tool. Furthermore, the BBI is a more comprehensive behavioural assessment for ALS, as it measures the whole behavioural spectrum in this condition. 相似文献
999.
Soiza RL Hughes NJ Leslie SJ Peden NR Hargreaves AD 《International journal of cardiology》2006,111(2):324-325
AIM: To assess if the TIMI Risk Score could predict early readmission. PARTICIPANTS: 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome. METHODS: A computerised clinical information system was interrogated to verify readmission. Area under the receiver operator characteristic curve and chi-square test for trend between TIMI Risk Score and readmission rate were calculated. RESULTS: Median follow up was 73 days. There was a strong association between TIMI Risk Score and readmission rate (chi-square test for trend, p<0.001), with an area under the receiver operator characteristic curve of 0.60 (95% C.I. 0.55-0.65). CONCLUSION: The TIMI Risk Score can predict readmission. This study reinforces its utility as a tool for identifying patients more likely to benefit from aggressive intervention. 相似文献
1000.
Deborah Mascalzoni A Cecile JW Janssens Alison Stewart Peter Pramstaller Ulf Gyllensten Igor Rudan Cornelia M van Duijn James F Wilson Harry Campbell Ruth Mc Quillan 《European journal of human genetics : EJHG》2010,18(3):296-302
Family-based research in genetically isolated populations is an effective approach for identifying loci influencing variation in disease traits. In common with all studies in humans, those in genetically isolated populations need ethical approval; however, existing ethical frameworks may be inadequate to protect participant privacy and confidentiality and to address participants'' information needs in such populations. Using the ethical–legal guidelines of the Council for International Organizations of Medical Sciences (CIOMS) as a template, we compared the participant information leaflets and consent forms of studies in five European genetically isolated populations to identify additional information that should be incorporated into information leaflets and consent forms to guarantee satisfactorily informed consent. We highlight the additional information that participants require on the research purpose and the reasons why their population was chosen; on the potential risks and benefits of participation; on the opportunities for benefit sharing; on privacy; on the withdrawal of consent and on the disclosure of genetic data. This research raises some important issues that should be addressed properly and identifies relevant types of information that should be incorporated into information leaflets for this type of study. 相似文献