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11.
Francesco Zanon Lina Marcantoni Enrico Baracca Gianni Pastore Giuseppina Giau Gianluca Rigatelli Daniela Lanza Claudio Picariello Silvio Aggio Sara Giatti Marco Zuin Loris Roncon Domenico Pacetta Franco Noventa Frits W. Prinzen 《Journal of interventional cardiac electrophysiology》2018,52(1):31-37
Purpose
Late cure after a previously failed ablation of ventricular arrhythmias (VAs) is a relatively common phenomenon. The present study sought to delineate the incidence and electrophysiological characteristics of late cure in idiopathic VA patients.Methods
Totally, 45 idiopathic VA cases (mean age 44?±?18 years, 27 males) either failed acutely or recurred within 12 h were enrolled in this study. Based on intensive clinical observations in the acute period, 19 (42%) patients demonstrated late cure in the first week after the procedure.Results
The late cure patients had significantly better acute and cumulative ablation effects during the procedure than did those without a late cure. Additionally, they had a prediction that originated from the right ventricular outflow tract, aortic-mitral continuum, and left summit area relative to other sites (13/18 vs 6/27, p?<?0.01). In a median follow-up of 24 [14, 46] months, 7/19 (37%) patients had their VAs recurred. The late cure group had significantly more patients cured at long-term follow-up than those without (12/19 vs 0/26, p?<?0.01). A cutoff value of the “time to eliminate VAs” >?7.0 s was able to predict a long-term recurrence of the VAs with 62.5% sensitivity and 85.7% specificity.Conclusions
The late cure of VAs occurs in more than one third of patients who have a seemingly unsuccessful ablation session, which is clustered in the first week after the procedure. However, long-term recurrence of VAs occurred in 37% of the late cure patients, emphasizing the importance of long-term follow-up.12.
Gonçalves DA Silva EV Graça FA Lira EC Zanon NM Mendes GE Burdmann EA Migliorini RH Kettelhut IC Navegantes LC 《The American journal of tropical medicine and hygiene》2008,79(5):771-778
This study investigated the in vivo effects of the Bothrops jararaca venom (BjV) on general metabolic profile and, specifically, on muscle protein metabolism in rats. The crude venom (0.4 mg/kg body weight, IV) was infused in awake rats, and plasma activity of enzymes and metabolites levels were determined after 1, 2, 3, and 4 hours. BjV increased urea, lactate, and activities of creatine kinase, lactate dehydrogenase, and aspartate aminotransferase after 4 hours. The content of liver glycogen was reduced by BjV. Protein metabolism was evaluated by means of microdialysis technique and in isolated muscles. BjV induced increase in the muscle interstitial-arterial tyrosine concentration difference, indicating a high protein catabolism. The myotoxicity induced by this venom is associated with reduction of protein synthesis and increase in rates of overall proteolysis, which was accompanied by activation of lysosomal and ubiquitin-proteasome systems without changes in protein levels of cathepsins and ubiquitin-protein conjugates. 相似文献
13.
B?.?Puccini L.?NassiEmail author C.?Minoia S.?Volpetti R.?Ciancia P.?C.?Riccomagno A.?Di Rocco A.?Mulè C.?Toldo M.?C.?Sassone R.?Guariglia C.?Filì E.?Finolezzi S.?Falorio S.?Zanon A.?Furlan G.?Doa F.?Zaja 《Annals of hematology》2017,96(7):1147-1153
Several studies suggested that staging bone marrow biopsy (BMB) could be omitted in patients with classical Hodgkin’s lymphoma (cHL) when a positron emission tomography/computed tomography (PET/CT) is performed at baseline.To address the concordance between BMB and PET/CT in the detection of bone marrow involvement (BMI) and the BMB role in determining the Ann Arbor stage, we retrospectively collected data on 1244 consecutive patients with cHL diagnosed from January 2007 to December 2013. One thousand eighty-five patients who had undergone both BMB and PET/CT were analyzed, comparing the Ann Arbor stage assessed with PET/CT only to that resulting from PET/CT combined with BMB.One hundred sixty-nine patients (16%) showed at least one focal skeletal lesion (FSL) at PET/CT evaluation. Only 55 patients had a positive BMB (5.1%); 34 of them presented at least one FSL at PET/CT. To the contrary, 895 out of 1030 patients with a negative BMB did not show any FSL (86.9%). Positive and negative predictive values of PET/CT for BMI were 20 and 98%, respectively; sensitivity and specificity were 62 and 87%, respectively. Fifty-four out of 55 patients with a positive BMB could have been evaluated as an advanced stage just after PET/CT; only one patient (0.1%) would have been differently treated without BMB.Our data showed a very high negative predictive value of PET/CT for BMI and a negligible influence of BMB on treatment planning, strengthening the recent indications that BMB could be safely omitted in cHL patients staged with PET/CT. 相似文献
14.
Human amniotic fluid-derived stem cells are rejected after transplantation in the myocardium of normal, ischemic, immuno-suppressed or immuno-deficient rat 总被引:10,自引:0,他引:10
15.
Aléssio AC Annichino-Bizzacchi JM Bydlowski SP Eberlin MN Vellasco AP Höehr NF 《American journal of medical genetics. Part A》2004,(3):256-260
Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms, folate, and B12 levels could contribute to plasma homocysteine (Hcy) variation. Although well established in adults, few studies have been performed in childhood. In this study, we investigated association of polymorphisms C677T and A1298C in the MTHFR gene and A66G in the MTRR gene with Hcy levels in children. These polymorphisms, as well as Hcy, folate, and vitamin B12 levels were investigated in 220 normal children with ages ranging from 1 to 8 years. Plasma Hcy, folate, and vitamin B12 levels were normal in all children. None of the polymorphisms could be considered an independent risk factor for hyperhomocysteinemia during childhood. The median Hcy levels in 37 children (17%) doubly heterozygous for C677T and A1298C mutations in the MTHFR gene were not different from the other genotypes. However, the association of the different genotypes with Hcy, folate, and vitamin B12 levels demonstrated significant P-values. The folate levels demonstrated a statistically significant decrease (P = 0.0477) from the C677T mutation in the MTHFR gene (TT genotype) when compared to the other groups. Folate was the only independent risk factor for hyperhomocysteinemia. Thus, monitoring the concentrations of folate would be more helpful for evaluating hyperhomocysteinemia and for preventing cardiovascular disease. 相似文献
16.
M. Neri G. B. Migliori A. Spanevello D. Berra E. Nicolin C. V. Landoni L. Ballardini M. Sommaruga P. Zanon 《Allergy》1996,51(5):313-319
The aims of the present study were as follows:
- 1). to evaluate the medical outcomes of two treatment and educational asthma programs
- 2). to determine by cost-analysis both cost and economic outcome of the programs
- 3). to perform a cost-benefit analysis (determining the net cost-benefit) and a cost-effectiveness analysis (determining the cost per unit of effect and the incremental cost-effectiveness ratio) from the perspective of health program policy makers (HPP; indirect costs, i.e., loss of productivity, excluded) and of society as a whole (Saw; all costs included).
17.
Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype 下载免费PDF全文
18.
The patients' movement in bed, is a procedure that demand great physical effort and use of good corporal mechanics for the nursing personnel, relative of preventing them back pain problems. Recognizing the importance of the movement and positioning, to promote safety and comfort to the patient, and before the professionals' complaints, described in the literature, this work has for objectives: to identify and analyzer the postures assumed by the nursing workers and identify the means and difficulties found during the execution of the referred activity. Through the technique of direct observation they were filmed, through videotapes, thirty procedures of patient's movement in the bed executed by nursing workers of an orthopedic clinic of an university hospital. The results evidence that the thirty procedures were executed along 197.41 minutes and that the corporal postures more frequently assumed they were, in respect to back, arms and legs, back inclined/arms with elbow down of row of seats/legs extension (53.76%). In agreement with the beginnings of the corporal mechanics and of the ergonomics, such postures are considered painful to the man, due to the muscle-skeletal aggressions and to the physical overload that they cart. The workers aimed the aspects little space (58.82%), physical load (52.94%) and absence of the personal (47.06%), as the main difficulties found in the execution of patient's movement in the bed, corroborating with the discoveries of the literature, characterizing that activity as painful. They pointed: the adequate technique (36.29%), used of sheet (35.29%) and space adequate (23.52%), as aspects that would facilitate the execution of the procedure. 相似文献
19.
20.
Percutaneous implantation of a catheter with subcutaneous reservoir for intraarterial regional chemotherapy: Technique and preliminary results 总被引:5,自引:0,他引:5
Grosso M Zanon C Mancini A Garruso M Gazzera C Anselmetti GC Veglia S Gandini G 《Cardiovascular and interventional radiology》2000,23(3):202-210
Purpose: We present the technique and the preliminary results of percutaneous implantation of intraarterial catheters connected to
a subcutaneous infusion reservoir for prolonged regional chemotherapy of hepatic and extrahepatic tumors.
Methods: Two hundred patients with primary or secondary hepatic neoplasms, pelvic, pancreatic, renal, lingual, and breast cancer underwent
the procedure. The access was the left axillary artery (188 patients) and the femoral artery (12 patients). The catheter tip
was placed in the hepatic (170 patients), hypogastric (18), splenic (4), internal thoracic (2), gastroduodenal (3), renal
(2) or the external carotid artery (1). The catheter was connected to a subcutaneous reservoir and filled with heparin; chemotherapeutic
infusion was subsequently started.
Results: One hundred percent immediate technical success was obtained. Forty-three of 200 (21.5%) patients had a complication: 29
patients had a catheter dislodgment, nine had arterial thrombosis, three had a pseudoaneurysm of the left axillary artery
and two had a port pocket hematoma. Most complications (37/43, 86%) were treated percutaneously without interruption of chemotherapy.
In only six cases (3% of the total population) was chemotherapy discontinued due to the complication itself. The mean duration
of catheter patency was 7.2 months.
Conclusion: Percutaneous placement of an intraarterial catheter is feasible and causes less discomfort to the patient than the surgical
approach. The technique has an acceptable complication rate (21.5%), similar to that for surgical implantation (17.8%), with
the advantage that in most cases the complications can be resolved percutaneously. This technique represents an alternative
to surgical implantation in the treatment of liver metastases from colorectal cancer and opens new therapeutic possibilities
for the local prolonged treatment of other kinds of tumor, though its clinical efficacy must be assessed in selected trials. 相似文献