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111.
Tamara Rogers Luba Kalaydjieva Joachim Hallmayer P. Brent Petersen Peter Nicholas Carmen Pingree William M. McMahon Donna Spiker Linda Lotspeich Helena Kraemer Patty McCague Sue Dimiceli Nassim Nouri Tawna Peachy Joan Yang David Hinds Neil Risch Richard M. Myers 《Journal of autism and developmental disorders》1999,29(3):195-201
Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families. 相似文献
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David Ribes Hélène E. L. Hachem Lucie Oberic François Vergez Audrey Delas Julie Belliere Caroline Protin Nassim Kamar Inès Ferrandiz Suzanne Tavitian Camille Laurent Antoine Huart Dominique Chauveau Loïc Ysebaert Stanislas Faguer 《American journal of hematology》2018,93(3):356-362
Treatment of indolent B‐cell non‐Hodgkin lymphomas (iNHL) of renal significance is challenging given the need for deep and prolonged hematological response to restore and control renal function overtime, yet to be balanced with the risk of adverse drug‐related events. This prospective single‐center study included 20 patients with iNHL of renal significance (tubulointerstitial presentation [n = 8], glomerulopathy with or without monoclonal Ig deposits [n = 12]) who received a steroid‐sparing regimen of rituximab plus bendamustine (BR), with either no or <1 month of steroid intake (as a first line therapy in 80%). Seventeen patients (85%) achieved a complete (CHR, n = 12) or a partial (PHR, n = 5) hematological response. Nine out of the 12 patients (75%) with iNHL‐related glomerulopathy had a complete (CRR) or a partial (PRR) renal response. Among the six patients with glomerulopathy and CHR, five had a CRR (83%) compared to 1/6 (17%) that did not reach CHR. eGFR increased from 38 to 58 mL/min/1.73 m2, and returned to baseline in five patients. Among the eight patients with a tubulointerstitial presentation, six (75%) had a renal response (5 CRR), and eGFR increased from 29 to 48 mL/min/1.73 m2. One patient with a PHR had a renal relapse. Mortality rate was 10% at 12 months. The BR regimen was well tolerated overall. Thus, despite severe renal disease at presentation, a relapsing iNHL in 20% of patients and several comorbidities, the BR regimen was efficient and safe in our series. It should be further assessed as a first line therapy for patients with iNHL of renal significance. 相似文献
114.
Incidental finding of arteria lusoria during transradial coronary catheterization: Significance in interventional cardiology
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Arsalan Rafiq MD Surendra Chutani MD Nassim R. Krim MD 《Catheterization and cardiovascular interventions》2018,91(7):1283-1286
Arteria lusoria is the most common anomaly of the aortic arch with an incidence of 0.5%–2.5%. It is mostly diagnosed incidentally while performing imaging for evaluation of other unrelated medical conditions. The aberrant right subclavian artery arises beyond the origin of the left subclavian artery from the aortic arch. This results in a complex right‐subclavian‐aortic anatomy which leads to difficulty in transradial coronary angiography. This can lead to prolonged procedure time and increased use of catheters by unaware interventionists. This is even more important if this is encountered in the setting of an acute myocardial infarction. Our review takes into account clinical significance of this uncommon anomaly in the field of interventional cardiology. 相似文献
115.
Elizabeth R. Lemoine BA Janelle S. Nassim BSc Jasmine Rana BA Susan Burgin MD 《International journal of dermatology》2018,57(2):233-236
Challenge: Trainees’ motivational and emotional states can influence their learning and career decisions, but historically these “affective” learning factors have received little attention in medical education. In this “Tips” piece, we outline strategies to positively influence trainees’ intrinsic motivation and emotion toward their training to ultimately enhance their overall learning experience. 相似文献
116.
Thomas Prudhomme Mathieu Roumigui Thibaut Benoit Marine Lesourd Jean Baptiste Beauval Nicolas Doumerc Federico Sallusto Michel Souli Nassim Kamar Xavier Gam 《Clinical transplantation》2019,33(12)
The main objective of this preliminary study was to evaluate the feasibility and safety of 3‐D laparoscopic living donor left nephrectomy (LDLN). The secondary objective was to compare intraoperative and postoperative outcomes between 3‐D and 2‐D laparoscopic LDLN. All patients who underwent a laparoscopic LDLN from January 2015 to April 2018 in a university center were included. All surgeries were performed by three experienced surgeons. Seventy three patients were included the following: 16 underwent a 3‐D laparoscopic LDLN (3‐D group), and 57 underwent a 2‐D laparoscopic LDLN (2‐D group). Operative time and warm ischemia time (WIT) were significantly lower in the 3‐D group (operative time: 80.9 ± 10.2 vs 114.1 ± 32.3 minutes in the 3‐D and 2‐D groups, P = .0002) (WIT: 1.7 ± 0.6 vs 2.3 ± 0.9 minutes in the 3‐D and 2‐D groups, P = .02). No conversion to open surgery occurred in both groups. Length of hospital stay was significantly shorter in the 3‐D group. No major postoperative complications (Clavien ≥ III) occurred. One‐year postoperative GFR was similar to 3‐D and 2‐D groups. Our preliminary study demonstrates that 3‐D laparoscopic LDLN is a feasible and safe surgical procedure. Intraoperative and postoperative outcomes were similar in both 2‐D and 3‐D vision systems, but 3‐D vision systems allow reduction in WIT and operative time. 相似文献
117.
Vishwanath Kumble Bhat Eva Bernhart Ioanna Plastira Kaiji Fan Nassim Ghaffari-Tabrizi-Wizsy Christian Wadsack Gerald Rechberger Thomas Eichmann Martin Asslaber Ivelina Spassova Monique E. Verhaegen Ernst Malle Jürgen C. Becker Wolfgang Sattler 《The Journal of investigative dermatology》2019,139(4):807-817
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Juan Del Coso Nassim Hamouti Roberto Aguado-Jimenez Ricardo Mora-Rodriguez 《European journal of applied physiology》2010,108(3):523-532
To determine which active-recovery protocol would reduce faster the high blood H+ and lactate concentrations produced by repeated bouts of high-intensity exercise (HIE). On three occasions, 11 moderately
trained males performed 4 bouts (1.5 min) at 163% of their respiratory compensation threshold (RCT) interspersed with active-recovery:
(1) 4.5 min pedalling at 24% RCT (SHORT); (2) 6 min at 18% RCT (MEDIUM); (3) 9 min at 12% RCT (LONG). The total work completed during recovery was the same in all three trials. Respiratory gases and arterialized-blood samples
were obtained during exercise. At the end of exercise, LONG in comparison to SHORT and MEDIUM increased plasma pH (7.32 ± 0.02 vs. ~7.22 ± 0.03; P < 0.05), while reduced lactate concentration (8.5 ± 0.9 vs. ~10.9 ± 0.8 mM; P < 0.05). Ventilatory equivalent for CO2 was higher in LONG than SHORT and MEDIUM (31.4 ± 0.5 vs. ~29.6 ± 0.5; P < 0.05). Low-intensity prolonged recovery between repeated bouts of HIE maximized H+ and lactate removal likely by enhancing CO2 unloading. 相似文献
120.
Panageas KS Iwamoto FM Cloughesy TF Aldape KD Rivera AL Eichler AF Louis DN Paleologos NA Fisher BJ Ashby LS Cairncross JG Roldán Urgoiti GB Wen PY Ligon KL Schiff D Robins HI Rocque BG Chamberlain MC Mason WP Weaver SA Green RM Kamar FG Abrey LE Deangelis LM Jhanwar SC Rosenblum MK Lassman AB 《Neuro-oncology》2012,14(6):761-767
Anaplastic oligodendroglial tumors are rare neoplasms with no standard approach to treatment. We sought to determine patterns of treatment delivered over time and identify clinical correlates of specific strategies using an international retrospective cohort of 1013 patients diagnosed from 1981-2007. Prior to 1990, most patients received radiotherapy (RT) alone as initial postoperative treatment. After 1990, approximately 50% of patients received both RT and chemotherapy (CT) sequentially and/or concurrently. Treatment with RT alone became significantly less common (67% in 1980-1984 vs 5% in 2005-2007, P < .0001). CT alone was more frequently administered in later years (0% in 1980-1984 vs 38% in 2005-2007; P < .0001), especially in patients with 1p19q codeleted tumors (57% of codeleted vs 4% with no deletion in 2005-2007; P < .0001). Temozolomide replaced the combination of procarbazine, lomustine, and vincristine (PCV) among patients who received CT alone or with RT (87% vs 2% in 2005-2007). In the most recent time period, patients with 1p19q codeleted tumors were significantly more likely to receive CT alone (with temozolomide), whereas RT with temozolomide was a significantly more common treatment strategy than either CT or RT alone in cases with no deletion (P < .0001). In a multivariate polytomous logistic regression model, the following were significantly associated with type of treatment delivered: date (5-year interval) of diagnosis (P < .0001), 1p19q codeletion (P < .0001), pure anaplastic oligodendroglioma histology (P < .01), and frontal lobe predominance (P < .05). Limited level 1 evidence is currently available to guide treatment decisions, and ongoing phase III trials will be critical to understanding the optimal therapy. 相似文献