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101.
Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection 总被引:4,自引:1,他引:4
Ferri C; La Civita L; Fazzi P; Solfanelli S; Lombardini F; Begliomini E; Monti M; Longombardo G; Pasero G; Zignego AL 《Rheumatology (Oxford, England)》1997,36(3):360-365
A possible aetiopathogenetic role of hepatitis C virus (HCV) has been
reported in various immune-mediated disorders, such as mixed
cryoglobulinaemia, which may be complicated by interstitial lung
involvement; moreover, different viruses, including HCV, have been
correlated with idiopathic pulmonary fibrosis. Here, a cohort of eight
HCV-positive patients (M/F = 4/4, mean age 61 +/- 8 S.D. yr) with
interstitial lung fibrosis and a variable number of rheumatic disorders are
described. Interstitial lung involvement appeared medially 4.5 +/- 3.2 S.D.
yr after the clinical onset of chronic hepatitis. During the clinical
follow-up, some rheumatic symptoms were also recorded: articular
involvement (four patients): mild sicca syndrome (one patient); severe
polymyositis and cranial neuropathy (one patient); serum cryoglobulins
and/or autoantibodies (eight patients). In all patients, a moderate (four
patients) or severe (four patients) lung fibrosis was evaluated by means of
high-resolution computed tomography. The presence of parenchymal
radiotracer uptake on 67Ga scan (7/7 patients) and increased percentages of
neutrophils (4/4 patients) and lymphocytes (2/4) at bronchoalveolar lavage
suggested an active lung involvement. Different degrees of reduction of
single breath diffusing capacity for carbon monoxide (DLco) (mean value
57.6 +/- 15%, range 37- 80) were observed in all cases, while spirometric
abnormalities, consistent with a global restrictive pattern, were less
frequently found. In all cases, anti-HCV antibodies and HCV viraemia were
demonstrated: viral genome was also detected in peripheral lymphocytes from
4/4 subjects and in one case in lung biopsy specimens. A desquamative
interstitial pneumonia pattern was demonstrated in two cases by lung
biopsy. The present work supports the hypothesis that HCV chronic infection
could represent a trigger factor for interstitial lung fibrosis and various
rheumatic disorders.
相似文献
102.
O Falusi AL French EC Seaberg PC Tien DH Watts H Minkoff E Piessens A Kovacs K Anastos MH Cohen 《Clinical infectious diseases》2002,35(11):1414-1417
We assessed the prevalence and predictors of latent Toxoplasma infection in a large group of human immunodeficiency virus (HIV)-infected and HIV-uninfected at-risk US women. The prevalence of latent Toxoplasma infection was 15% (380 of 2525 persons) and did not differ by HIV infection status. HIV-infected women aged > or =50 years and those born outside of the United States were more likely to have latent Toxoplasma infection, with prevalences of 32% and 41%, respectively. 相似文献
103.
Epstein AL; Samoszuk M; Stathopoulos E; Naeve GS; Clevenger CV; Weil S; Marder RJ 《Blood》1987,70(4):1124-1130
A monoclonal antibody, designated BM-1, which is reactive in B5 formalin-fixed, paraffin-embedded tissues, has been generated against a cytoplasmic and nuclear antigen expressed in human myeloid precursor cells and derived leukemias. Using the avidin-biotin-complex immunoperoxidase procedure, BM-1 was found to stain selectively myeloid precursor cells in normal bone marrow and mature granulocytes in the blood. In a screen of 26 normal adult and fetal human organs fixed in B5 formalin, BM-1 was negative in all nonhematopoietic tissues with the exception of tissue granulocytes and scattered cells in the peripheral cortex of the thymus. Likewise a screen of 30 solid tumor cell lines including a spectrum of carcinomas, sarcomas, and neural-derived tumors was negative. BM-1 was also negative with 21 T and B cell lymphomas and 11 Hodgkin's disease tumors. A preliminary study of tumors of the hematopoietic system revealed that BM-1 was reactive with M2 and M3 acute myelogenous leukemias (AML), chronic myelogenous leukemias (CML) and myelomonocytic leukemias, and granulocytic sarcomas. M1, M4, M5, and M6 AML clot preparations were negative in this study, indicating that BM-1 may have a role in the histopathologic diagnosis of myelogenous leukemia. Myeloid leukemic cell lines HL-60, ML-2, KG1, and TPH-1-O showed BM-1 nuclear and/or cytoplasmic reactivity in a subpopulation of cells, but erythroid and lymphoid leukemias and all lymphoma cell lines were negative. Immunoperoxidase studies of a panel of fetal tissues showed BM-1 positive cells in the peripheral cortex of the thymus and portal myelopoietic regions of the liver at 18 weeks gestation. Finally, DNA-cellulose and solid phase radioimmunoassay (RIA) techniques developed in our laboratory demonstrate that the BM-1 antigenic domain is reactive only after binding to eukaryotic but not prokaryotic single- or double-stranded DNA. Immunoblot techniques using a DNA-cellulose purified protein sample revealed that BM-1 recognizes a 183 kD protein. These studies indicate that BM-1 is recognizing a myeloid-specific antigen that, because of its DNA binding characteristics, may have an important role in the differentiation of myeloid cells at the molecular level. 相似文献
104.
105.
Medhat A. F. SHALABY Suliman M. AL HUMAYED Ahmed M. DEWEDAR Tunis A. EL‐SAEED 《International journal of rheumatic diseases》2008,11(3):311-314
Rosai‐Dorfman disease (RDD) is a rare benign reactive lymphoproliferative disorder characterised by a histopathological pattern with sinus histiocytosis and hemophagocytosis. It usually presents with fever, elevated erythrocyte sedimentation rate, cervical lymphadenopathy, other lymph node and extra‐nodal site involvement. We present the case of a 25‐year‐old female patient with polyarthritis mimicking rheumatoid arthritis (RA). When the para‐aortic lymph node was biopsied, it showed extensive histiocytic proliferation; some clusters of plasma cells, lymphocytes and rare multinucleated cells were seen, suggesting a diagnosis of RDD. There is nothing in the literature regarding the polyarthritic presentation of the disease. To the best of our knowledge, our patient is the first case of RDD presenting with a clinical picture mimicking atypical seronegative RA. 相似文献
106.
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109.
Quality of Life Questionnaires for the Assessment of Pelvic Organ Prolapse: Use in Clinical Practice
Ahmed AL‐BADR 《Lower urinary tract symptoms.》2013,5(3):121-128
Over the past decade, the use of quality of life (QOL) questionnaires in the evaluation of pelvic organ prolapse (POP) has become a standard part of most clinical studies. Investigators have attempted to correlate QOL scores with objective findings and treatment efficacy and as outcome measures in comparing different treatment modalities. Many of the QOL questionnaires are available in short forms, making them easier to adapt to clinical settings. This article includes an overview of several validated QOL questionnaires and their application in studies whose results provide useful guidelines for health care professionals who diagnose and manage women with POP. 相似文献
110.
Alison M Hall Lee AL Poole Bryan Renton Alexa Wozniak Michael Fisher Timothy Neal Christopher M Halloran Trevor Cox Peter A Hampshire 《Critical care (London, England)》2013,17(2):R49