全文获取类型
收费全文 | 4050篇 |
免费 | 230篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 117篇 |
妇产科学 | 27篇 |
基础医学 | 580篇 |
口腔科学 | 86篇 |
临床医学 | 256篇 |
内科学 | 1153篇 |
皮肤病学 | 23篇 |
神经病学 | 253篇 |
特种医学 | 180篇 |
外科学 | 758篇 |
综合类 | 19篇 |
预防医学 | 78篇 |
眼科学 | 22篇 |
药学 | 212篇 |
中国医学 | 6篇 |
肿瘤学 | 552篇 |
出版年
2024年 | 1篇 |
2023年 | 37篇 |
2022年 | 66篇 |
2021年 | 132篇 |
2020年 | 62篇 |
2019年 | 75篇 |
2018年 | 135篇 |
2017年 | 88篇 |
2016年 | 118篇 |
2015年 | 133篇 |
2014年 | 160篇 |
2013年 | 179篇 |
2012年 | 353篇 |
2011年 | 351篇 |
2010年 | 173篇 |
2009年 | 155篇 |
2008年 | 254篇 |
2007年 | 289篇 |
2006年 | 270篇 |
2005年 | 214篇 |
2004年 | 225篇 |
2003年 | 238篇 |
2002年 | 195篇 |
2001年 | 37篇 |
2000年 | 41篇 |
1999年 | 46篇 |
1998年 | 52篇 |
1997年 | 35篇 |
1996年 | 34篇 |
1995年 | 31篇 |
1994年 | 20篇 |
1993年 | 26篇 |
1992年 | 34篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1970年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有4330条查询结果,搜索用时 31 毫秒
51.
Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection
下载免费PDF全文
![点击此处可从《Digestive endoscopy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Naoto Iwai Osamu Dohi Yuji Naito Yutaka Inada Akifumi Fukui Shun Takayama Kazuyuki Ogita Kei Terasaki Takahiro Nakano Tomohiro Ueda Tetsuya Okayama Naohisa Yoshida Kazuhiro Katada Kazuhiro Kamada Kazuhiko Uchiyama Takeshi Ishikawa Osamu Handa Tomohisa Takagi Hideyuki Konishi Nobuaki Yagi Yoshito Itoh 《Digestive endoscopy》2018,30(5):616-623
52.
Makio Kusaoi Go Murayama Naoto Tamura Ken Yamaji 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(5):530-547
The aim of this paper was to explain the insurance coverage status of therapeutic apheresis (excluding CHDF) in Japan, alongside the social system of medical reimbursement and concerns regarding the future sustainability of the healthcare system. Insurance schemes and premiums differed for individuals at different levels in the society (eg, municipal residents, employees, and public servants). Insurance premiums and their rates varied depending on the total household income, the number of people living together, age, and the place of residence. In addition, the medical expense subsidies for children through public expenditure were also described. Japan's generous insurance system and multiple medical expense subsidies provide financial support for patients. With Japan's history of medical expense subsidies based on the policy of supporting intractable diseases, we have established an environment where all citizens can receive therapeutic apheresis when needed if they are affected by a disease for which insurance coverage is indicated. 相似文献
53.
Yukiko Hasuike Naoto Kakita Makoto Aichi Satoko Masachika Mari Kantou Shoko Ikeda Takahashi Masayoshi Nanami Yasuyuki Nagasawa Takahiro Kuragano Takeshi Nakanishi 《Journal of vascular surgery》2019,69(1):174-180.e2
Objective
For patients with end-stage renal disease on hemodialysis, the durability of vascular access (VA) is still far from optimal, and access survival after intervention for access failure is an important aspect. Procoagulant status is a leading cause of access failure. Coagulation-fibrinolysis imbalance can occur in hemodialyzed patients, but the influence of the imbalance has not been fully elucidated.Methods
We prospectively examined coagulation-fibrinolysis balance to assess the risk of access failure after the intervention of revascularization in a cohort of 462 hemodialysis patients. Thrombin-antithrombin complex (TAT) and plasmin-α2-plasmin inhibitor complex (PIC) are markers for coagulation and fibrinolysis. Median follow-up was 243 days. The end point was clinical access failure: revascularization or access revision. The survival curve for VA patency was assessed using the Kaplan-Meier method and compared using the log-rank test. Cox proportional hazards regression models that allowed adjustment for baseline differences in age, sex, dialysis vintage, diabetes mellitus, and various factors (quantity of blood flow, prothrombin time-international normalized ratio, fibrin degradation products, C-reactive protein, interleukin-6, tumor necrosis factor-α, and pentraxin-3) were used.Results
The 162 patients who reached an end point had smaller access flow volume and smaller percentage of arteriovenous fistula and higher TAT/PIC ratio. Kaplan-Meier analysis indicated that the patients with elevated TAT/PIC ratio showed poorer outcome (P < .001). On Cox regression modeling, elevated TAT/PIC was an independent risk factor for access failure (hazard ratio, 1.58; P = .03).Conclusions
Our results suggest that coagulation-fibrinolysis imbalance is a significant risk factor for access failure and may predict VA failure in hemodialyzed patients after access intervention. 相似文献54.
55.
Ha Ngoc Giang Kenji Kinashi Wataru Sakai Naoto Tsutsumi 《Macromolecular chemistry and physics.》2012,213(9):982-988
A new class of photorefractive (PR) composite based on a fully functionalized polymer with high phase‐stability is reported. The polymer containing non‐linear optical (NLO) chromophores and charge‐transporting carbazole moieties is synthesized by a polymer‐analogous reaction. The polymer is doped with plasticizer, NLO dye, and sensitizer to fabricate the PR composite. The NLO dye is the same as the NLO chromophore moiety in the polymer side chain. The PR performance of the composite is evaluated by degenerated four‐wave mixing and two‐beam coupling measurements. A diffraction efficiency of 30% at a relatively low applied electric field of 45 V μm?1 is achieved. Despite a high concentration of NLO dye, the composites show good stability for a long period without phase separation. 相似文献
56.
Naoto Shirasu Hiromi Yamada Hirotomo Shibaguchi Motomu Kuroki Masahide Kuroki 《International journal of cancer. Journal international du cancer》2014,135(11):2697-2710
Conventional photodynamic therapy (PDT) for cancer is limited by the insufficient efficacy and specificity of photosensitizers. We herein describe a highly effective and selective tumor‐targeted PDT using a near‐infrared (NIR) photosensitizer, IRDye700DX, conjugated to a human monoclonal antibody (Ab) specific for carcinoembryonic antigen (CEA). The antitumor effects of this Ab‐assisted PDT, called photoimmunotherapy (PIT), were investigated in vitro and in vivo. The Ab‐IRDye conjugate induced potent cytotoxicity against CEA‐positive tumor cells after NIR‐irradiation, whereas CEA‐negative cells were not affected at all, even in the presence of excess photoimmunoconjugate. We found an equivalent phototoxicity and a predominant plasma membrane localization of Ab‐IRDye after both one and six hours of incubation. Either no or little caspase activation and membrane peroxidation were observed in PIT‐treated cells and a panel of scavengers for reactive oxygen species showed only partial inhibition of the phototoxic effect. Strikingly, Ab‐IRDye retained significant phototoxicity even under hypoxia. We established a xenograft model, which allowed us to sensitively investigate the therapeutic efficacy of PIT by non‐invasive bioluminescence imaging. Luciferase‐expressing MKN‐45‐luc human gastric carcinoma cells were subcutaneously implanted into both flanks of nude mice. NIR‐irradiation was performed for only the tumor on one side. In vivo imaging and measurement of the tumor size revealed that a single PIT treatment, with intraperitoneal administration of Ab‐IRDye and subsequent NIR‐irradiation, caused rapid cell death and significant inhibition of tumor growth, but only on the irradiated side. Together, these data suggest that Ab‐IRDye‐mediated PIT has great potential as an anticancer therapeutics targeting CEA‐positive tumors. 相似文献
57.
Healing of two‐wall intra‐bony defects treated with a novel EMD‐liquid—A pre‐clinical study in monkeys
下载免费PDF全文
![点击此处可从《Journal of clinical periodontology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
58.
59.
60.
Yoshiyuki Nakatsuji Kendo Kiyosawa Eiji Tanaka Takeshi Sodeyama Naoto Horigome Shoji Kajikawa Shigeko Naito Yoshihiro Akahane 《Liver international》1991,11(3):176-184
ABSTRACT— To clarify the discrepancy in hepatitis B surface antigen (HBsAg) subtypes present in the serum and liver, as well as among hepatocytes, liver specimens which were resected from 37 HBsAg-positive patients with hepatocellular carcinoma (HCC) were examined. We evaluated HBsAg and the subtypic determinants of HBsAg and hepatitis B core antigen (HBcAg) using the peroxidase-antiperoxidase (PAP) staining method. Hepatitis B antigens were more frequently detected in small tumors (HBsAg in 67%, HBcAg in 40%) than in large ones (HBsAg in 36%, HBcAg in 14%). The prevalence of each subtypic determinant in the HBsAg positive non-tumorous vs. tumorous areas was 100% vs. 67% in a, 100% vs. 57% in d, 100% vs. not tested in y, 100% vs. 53% in r and 25% vs. 0% in w (a, d, y, r and w represent subtypic determinants). There was virtually no difference in a set of subtypic determinants between the serum and liver. However, there were some variations in a set of subtypic determinants among the hepatocytes. On the other hand, liver tissue of compound subtype adyr in serum contained both cells with a,d,r and with a,y,r as well as a few cells with a,d,y,r. These findings suggest that HBV genomes in hepatocytes of type B chronic liver disease may differ genetically among cells even in the same liver tissue. 相似文献