全文获取类型
收费全文 | 4910篇 |
免费 | 295篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 118篇 |
妇产科学 | 66篇 |
基础医学 | 752篇 |
口腔科学 | 76篇 |
临床医学 | 331篇 |
内科学 | 1288篇 |
皮肤病学 | 256篇 |
神经病学 | 332篇 |
特种医学 | 104篇 |
外科学 | 460篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 263篇 |
眼科学 | 147篇 |
药学 | 367篇 |
中国医学 | 14篇 |
肿瘤学 | 593篇 |
出版年
2024年 | 5篇 |
2023年 | 29篇 |
2022年 | 91篇 |
2021年 | 156篇 |
2020年 | 103篇 |
2019年 | 97篇 |
2018年 | 161篇 |
2017年 | 123篇 |
2016年 | 148篇 |
2015年 | 116篇 |
2014年 | 170篇 |
2013年 | 242篇 |
2012年 | 344篇 |
2011年 | 366篇 |
2010年 | 198篇 |
2009年 | 197篇 |
2008年 | 343篇 |
2007年 | 360篇 |
2006年 | 336篇 |
2005年 | 317篇 |
2004年 | 319篇 |
2003年 | 283篇 |
2002年 | 275篇 |
2001年 | 42篇 |
2000年 | 29篇 |
1999年 | 41篇 |
1998年 | 53篇 |
1997年 | 51篇 |
1996年 | 33篇 |
1995年 | 27篇 |
1994年 | 20篇 |
1993年 | 26篇 |
1992年 | 14篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 16篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 8篇 |
1981年 | 3篇 |
1975年 | 2篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 13篇 |
1971年 | 3篇 |
1969年 | 3篇 |
排序方式: 共有5225条查询结果,搜索用时 15 毫秒
81.
Humic acid induces the endothelial nitric oxide synthase phosphorylation at Ser1177 and Thr495 Via Hsp90α and Hsp90β upregulation in human umbilical vein endothelial cells
下载免费PDF全文
![点击此处可从《Environmental toxicology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Masato Tanaka Miki Miyajima Naoko Hishioka Ryo Nishimura Yusuke Kihara Toshiyuki Hosokawa Masaaki Kurasaki Shunitz Tanaka Takeshi Saito 《Environmental toxicology》2015,30(2):223-231
Humic acid (HA) has been implicated as a contributory factor for blackfoot disease, which is an endemic peripheral vascular disease. We investigated the effect of HA on the regulation of endothelial nitric oxide (NO) synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) to evaluate the involvement of eNOS and related factors in peripheral vascular impairment with HA exposure. Treatment of HUVECs with HA induced upregulation of eNOS. This result coincides with those of previous studies. Furthermore this is the first study to report that HA induces upregulation of heat shock protein (Hsp)90α, Hsp90β, eNOS phosphorylation at Ser1177, and eNOS phosphorylation at Thr495, as compared to that in the control. In contrast, treatment with BAPTA, an intracellular Ca2+ chelator, inhibited upregulation of these proteins induced by HA. This study demonstrates that HA treatment leads to increases in both Hsp90α and Hsp90β proteins and indicates that Hsp90α leads to eNOS phosphorylation at Ser1177 and that Hsp90β leads to eNOS phosphorylation at Thr495, respectively. Upregulation of eNOS, Hsp90α, and Hsp90β in HUVECs is regulated by intracellular Ca2+ accumulation induced by HA. These results suggest that upregulation of eNOS phosphorylation at Ser1177 and eNOS phosphorylation at Thr495 produce NO and superoxide anions, respectively, resulting in generation of peroxynitrite, which causes impairment of vascular endothelial cells. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 223–231, 2015. 相似文献
82.
83.
Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
84.
Naoko Ito Masatoki Sato Nobuo Momoi Yoshimichi Aoyagi Kisei Endo Mina Chishiki Yukihiko Kawasaki Mitsuaki Hosoya 《Pediatrics international》2015,57(6):1172-1174
A 9‐year‐old girl developed influenza A H1N1 pdm09‐associated myocarditis and pericarditis 2 days after starting zanamivir therapy. The virus was detected in the respiratory tract but not in the serum or pericardial effusion. The virus sampled from the respiratory tract had normal susceptibility to neuraminidase inhibitors. Although no differences in interferon‐γ, interleukin (IL)‐1β, and tumor necrosis factor‐α were observed between the plasma and pericardial effusion, some inflammatory cytokines or chemokines (IL‐6 and IL‐8) and vascular endothelial growth factor were remarkably elevated in the pericardial effusion compared with the plasma. This suggested that the influenza virus, after infecting the respiratory tract, affected the myocardium, causing myocarditis to gradually develop, which might have been followed by an autoreactive pericarditis causing increased pericardial effusion. Therefore, influenza‐associated myocarditis should be considered when influenza patients have respiratory and cardiac involvement, even during treatment with a neuraminidase inhibitor. 相似文献
85.
The age-related changes in acute insulin response after glucose loading and the influence of suppression of body weight gain were investigated by using blood samples from portal and peripheral veins. We placed indwelling catheters in the portal vein of 12- and 24- wk-old Otsuka Long-Evans Tokushima fatty (OLETF) rats (n = 8, 12), and age-matched control Long-Evans Tokushima Otsuka (LETO) rats (n = 8, 6). To suppress the body weight gain, 6 out of 12 OLETF rats were fed chow containing 50 ppm voglibose (VOG) from 8 until 24 wk of age. After fasting for 17 h, rats underwent 1 g/kg oral glucose tolerance test (OGTT). Peripheral glucose levels after glucose loading were significantly higher in 12- and 24-wk-old OLETF rats than in the age-matched LETO rats. Values for delta insulin 15 min/delta glucose 15 min (delta I15 min/delta G15 min) in portal blood were 0.029 +/- 0.011 and 0.009 +/- 0.009 (12 wk of age) and 0.03 +/- 0.03 and -0.01 +/- 0.01 (24 wk of age) in the LETO rats and OLETF rats. At the age of 24 wk, the body weights in VOG-treated OLETF rats were significantly lower than those in the OLETF rats. And there was significantly greater acute insulin response to glucose in VOG-treated OLETF rats than in the OLETF rats. Acute insulin response to glucose decreased with advancing age and the suppression of body weight gain preserved the response in spontaneously type 2 diabetic rats with visceral fat obesity. 相似文献
86.
87.
Asaoka Kohei Watanabe Yuki Itoh Kazuhiro Hosono Naoko Hirota Tomoya Ikawa Masamichi Yamaguchi Tomohisa Hatta Satomi Imamura Yoshiaki Nishino Ichizo Yamauchi Takahiro Iwasaki Hiromichi 《Clinical rheumatology》2021,40(6):2477-2483
Clinical Rheumatology - Eosinophilic fasciitis (EF) is a rare connective tissue disease that causes inflammation and fibrosis of the fascia, inducing pain and motor dysfunction. Characteristic skin... 相似文献
88.
Shingo Nasu Kunimitsu Kawahara Yuki Han Norio Okamoto Yoshitaka Tamura Hidekazu Suzuki Takayuki Shiroyama Yumiko Samejima Tomohiro Kanai Yoshimi Noda Ayako Tanaka Naoko Morishita Kayo Ueda Shoji Hashimoto Tomonori Hirashima Takayuki Nagai 《Internal medicine (Tokyo, Japan)》2021,60(3):445
Miliary tuberculosis is a potentially lethal type of tuberculosis that results from the hematogenous dissemination of Mycobacterium tuberculosis bacilli. We herein describe the case of a 34-year-old man that presented with a one-month history of cough and fever, while his sputum smear results were negative. Chest computed tomography revealed bilateral centrilobular ground-glass opacification (GGO), suggestive of hypersensitivity pneumonitis; thus, bronchoscopy was performed. Cryobiopsy specimens revealed necrotic granulomas. A re-examination of sputum after bronchoscopy identified Mycobacterium tuberculosis, and miliary tuberculosis was diagnosed. A cryobiopsy might be useful for diagnosing miliary tuberculosis pathologically, particularly when miliary nodules may be masked by GGO. 相似文献
89.
Tatsuya Shimizu Chie Saito Megumi Watanabe Ryota Ishii Tetsuya Kawamura Kei Nagai Akiko Fujita Shuzo Kaneko Hirayasu Kai Naoki Morito Joichi Usui Masahiro Yokosawa Yuya Kondo Sae Inoue Naoko Okiyama Kunihiro Yamagata 《Internal medicine (Tokyo, Japan)》2021,60(7):1101
A 40-year-old Japanese woman developed malignant-phase hypertension complicated by thrombotic microangiopathy, progressing to end-stage renal disease. Five years later, she was diagnosed with pulmonary arterial hypertension and interstitial pneumonia. Despite a lack of overt skin sclerosis, nucleolar staining in our indirect immunofluorescence analysis and nailfold capillaroscopy facilitated the diagnosis of anti-PM/Scl antibody-positive systemic sclerosis. We observed the persistent presence of anti-PM/Scl antibodies throughout the clinical course, suggesting that her kidney disease was scleroderma renal crisis. Anti-PM/Scl antibodies can be associated with multiple organ diseases. Careful attention to a patient''s antinuclear antibody pattern and dermatological findings may help clarify the etiology of undiagnosed diseases. 相似文献
90.
Shinichi Wada Mayu Kamei Naoko Uehara Koji Tsuzaki Toshiaki Hamano 《Internal medicine (Tokyo, Japan)》2021,60(10):1607
A 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX-1 antibodies. He was diagnosed with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS). He died from aspiration pneumonia on day 9. Small-cell lung carcinoma (SCLC), which had not been obvious on computed tomography, was found during the autopsy. Patients with PCD-LEMS who test positive for SOX-1 antibodies should be carefully evaluated for SCLC. 相似文献