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21.
Meital Portugal-Cohen Liran Horev Claas Ruffer Gerrit Schlippe Werner Voss Ze’evi Ma’or Miriam Oron Yoram Soroka Marina Frušić-Zlotkin Yoram Milner Ron Kohen 《Biomedicine & Pharmacotherapy》2012
Background
Psoriasis and atopic dermatitis (AD) are challenging to treat due to the absence of suitable monitoring procedure and their recurrences. Alteration of skin hydrophilic biomarkers (SHB) and structural elements occur in both disorders and may possess a distinct profile for each clinical condition.Objective
To quantify skin cytokines and antioxidants non-invasively in psoriatic and in AD patients and to evaluate skin auto-fluorescence in psoriatic patients.Methods
A skin wash sampling technique was utilized to detect the expression of SHB on psoriatic and AD patients and healthy controls. Inflammatory cytokine (TNFα, IL-1α and IL-6) levels, total antioxidant scavenging capacity and uric acid content were estimated. Additionally, measurement of the fluorescent emission spectra of tryptophan moieties, collagen cross-links and elastin cross-links were performed on psoriatic patients and healthy controls.Results
Our findings demonstrate significant alterations of the SHB levels among psoriasis, AD and healthy skin. Differences were also observed between lesional and non-lesional areas in patients with psoriasis and AD. Ultra-structural changes were found in psoriatic patients both in lesional and non-lesional areas.Conclusion
Employing non-invasive measurements of skin wash sampling and skin auto-fluorescence might serve as complementary analysis for improved diagnosis and treatment of psoriasis and AD. Furthermore, they may serve as an additional monitoring tool for various diseases, in which skin dysfunction is involved. 相似文献22.
23.
Eshkol-Yogev Inbar Kaufman Anat Haddad Marwan Zilberman Meital 《Odontology / the Society of the Nippon Dental University》2022,110(2):296-304
Odontology - The development of hydrogels for maxillofacial bone regeneration holds vast potential. However, some challenges need to be addressed to further their application in clinical settings.... 相似文献
24.
Avinoam Pirogovsky Meital Adi Amit Dagan Levana Sinai Dalia Sthoeger Naphtali Barzilai Elvan Tabachnik 《Pediatric radiology》2001,31(10):709-711
A 2-year-old boy with new-onset nephrotic syndrome developed recurrent vomiting, apathy and papilloedema. Superior sagittal
sinus thrombosis was diagnosed on cranial CT and MRI. He gradually recovered after treatment with heparin, fresh frozen plasma
and warfarin with complete resolution of the thrombosis after 1 month. Superior sagittal sinus thrombosis is an extremely
rare complication of nephrotic syndrome in children. Early diagnosis is essential for institution of anticoagulation therapy
and a successful outcome.
Received: 21 November 2000 Accepted: 19 March 2001 相似文献
25.
Gil-Ad I Zolokov A Lomnitski L Taler M Bar M Luria D Ram E Weizman A 《International journal of oncology》2008,33(2):277-286
Evidence has been provided of the anti-proliferative activity of certain antidepressants, mainly the selective serotonin reuptake inhibitors (SSRIs). We tested the effect of different antidepressants on cell viability and proliferation of human colorectal carcinoma cell lines HT29 and the multi-drug resistant (MDR) LS1034. The SSRIs, paroxetine and sertraline, induced a dose-dependent inhibition of cell viability and proliferation in the two cell lines (IC50 8-15 micro M). When compared to cytotoxic agents e.g. doxorubicin, vincristine and 5-fluorouracil, the SSRIs showed comparable activity (HT29) or a superior effect (LS1034). Using flow cytometry analysis, we found that the two SSRIs arrested cells at the G0/G1 stage and stimulated DNA fragmentation in a dose-dependent manner. The SSRIs (10 and 20 microM) increased caspase-3 activation. Western blot analysis showed an increase after 24 h in c-Jun and a decrease in the expression of the anti-apoptotic protein Bcl-2. The results suggest a proapoptotic activity for the active SSRIs accompanied by mitogen-activated protein kinase cascade activation and Bcl-2 inhibition. In vivo, we used CD1 nude mice xenografted subcutaneously with HT29 cells. On day 8, after cell inoculation sertraline or paroxetine (15 mg/kg x3/week i.p.) were administered to animals (6/group), which were monitored weekly (for 5 weeks) for tumor volume and body weight. At 5 weeks, the animals survived, with no significant difference in body weight. Sertraline, though not paroxetine, significantly inhibited tumor growth. Collectively, our results suggest that the widely-used antidepressant, sertraline, possesses a potential anti-tumor activity, which circumvents the MDR mechanism. Since SSRI therapy is frequently indicated in cancer patients, the use of sertraline in colon cancer patients with co-morbidity of depression seems attractive. 相似文献
26.
Oded Cohen Hadar Rotem Betito Meital Adi Yael Shapira-Galitz Doron Halperin Yonatan Lahav Meir Warman 《Clinical anatomy (New York, N.Y.)》2020,33(7):1019-1024
The relation between pharyngeal tonsil and the bony nasopharynx determines the nasopharyngeal airway patency. Despite its importance, an anatomical study utilizing advanced imaging has not been conducted. The aim of the study was to evaluate the pharyngeal tonsil and bony nasopharynx depth and their ratio (adenoid-nasopharyngeal ratio [ANR]) with relation to sex and age in the general pediatric population. After excluding reported history of adenoidectomy, acute upper airway illness, allergy, and poor quality, 200 randomly selected head computed tomographies (CTs) of children were evaluated. CTs were divided into five age groups (0–5, 5.1–8, 8.1–11, 11.1–14, and 14.1–17 years). For each CT scan, the pharyngeal tonsil, bony nasopharynx and ANR values were calculated. A significant difference was found in the bony nasopharynx and pharyngeal tonsil depth between the five age subgroups (P < 0.001). Both bony nasopharynx and pharyngeal tonsil depth significantly increased between the age groups of 0–5 years to 5.1–8 years (4.17 mm increase, P < 0.001 and 3.47 mm increase, P < 0.009, respectively). The pharyngeal tonsil depth gradually decreases following the age of 8 years. No difference was found between age groups beyond age of eight for both the pharyngeal tonsil tissue and the bony nasopharynx. The ANR has an upward trend in the age group of 5.1–8 years. No sexual predilection was found. The bony nasopharynx and the pharyngeal tonsil tissue both grow during childhood. Different growth rates result in the narrowest airway in the age group of 5.1–8 years (ANR peak). These growth curves should be taken under consideration when treating pediatric pharyngeal tonsil hypertrophy. Clin. Anat., 33:1019–1024, 2020. © 2019 Wiley Periodicals, Inc. 相似文献
27.
Oded Cohen Meir Warman Moran Fried Hagit Shoffel-Havakuk Meital Adi Doron Halperin Yonatan Lahav 《Auris, nasus, larynx》2018,45(1):96-102
Objective
To study volume characteristics of the maxillary, sphenoid and frontal sinuses among healthy Caucasians adults, using computed tomography (CT) scans.Methods
A retrospective, case series study in a single academic center, CT scans of 201 consecutive adult subjects, performed between January and September 2014, were reviewed for the volume and dimensions of the paranasal sinuses. Patients with documented sinus pathology or lack of pneumatization were excluded.The study population was subdivided by gender and age (50 men age 25–64; 51 men age ≥65; 50 women age 25–64, and 50 women age ≥65).Results
The mean volume of maxillary, sphenoid and frontal sinuses in the four groups were 12.75 ± 4.38 cc; 4.00 ± 1.99 cc and 2.92 ± 2.57 cc, respectively. In both genders, older patients demonstrated a significantly lower volume of the maxillary and sphenoid sinuses (14.81 ± 3.96 cc vs. 11.82 ± 4.28 cc and 4.84 ± 1.97 vs. 3.84 ± 1.89 cc respectively; p < 0.001). No age related difference was found in the frontal sinus. Males had significantly larger sinus volumes than females (p < 0.001): maxillary 14.38±(4.64) vs. 12.23 ± (3.82) cc, sphenoid 4.74 ± (2.06) vs. 3.55 ± (1.73) cc, frontal 3.74 ± (2.97) vs. 3.21 ± (2.79) cc. No synergistic effect of age and gender was found.Conclusion
Volumes of the paranasal sinuses correlates with age and gender. Age related volume degeneration is expected in the maxillary and sphenoid sinuses. This volume reduction may influence future surgical and therapeutic approaches in the geriatric population. 相似文献28.
Einat Yehene Yael Zaksh Meital Davidian Ofri Bar-Nadav Maya Elyashiv 《Death Studies》2020,44(8):510-520
AbstractDeath or prolonged disorders of consciousness (DOC) of a loved one are both considered relational-losses that severely disrupt attachment-bonds. Grief in both conditions was compared by exploring the impact of familial-role and attachment-orientation. In DOC, caregivers’ grief was found significantly intensified relative to Death. Familial-role impacted grief in both conditions alike, with partners' heightened grief in DOC reflecting the complexity of their stagnant bonds. In Death, avoidance-attachment mitigated grief, while in DOC anxiety-attachment accentuated grief, we suggest that while physical-separation in death facilitates the modification of continuing attachment-schema, in DOC, modification may be required while the patient is still alive. 相似文献
29.
Amir Kraitzer Yoel Kloog Roni Haklai Meital Zilberman 《Journal of pharmaceutical sciences》2011,100(1):133-149
Composite core/shell fiber structures loaded with the antiproliferative drugs paclitaxel or farnesylthiosalicylate (FTS) were developed and studied. The latter is a specific nontoxic Ras inhibitor with a mild hydrophobic nature, which can also be used for local cancer treatment and stent applications. The fibers were composed of a dense polyglyconate core and a porous drug-loaded poly(d,l-lactic-glycolic acid) shell, prepared using freeze drying of inverted emulsions. Our study focused on the release profile of the antiproliferative drugs from the fibers, the shell morphology and its degradation and erosion. The postfabrication antiproliferative effect of the drugs was tested in a cell culture. The process parameters were found to affect the drug-release profile via two routes: (1) direct, through water uptake and swelling of the structure leading to FTS release, or through degradation of the host polymer leading to paclitaxel release at a later stage; (2) indirect effect of the microstructure on the release profile. The fabrication process did not reduce the pharmacological activity of either paclitaxel or FTS. FTS-eluting composite fibers proved to effectively induce growth inhibition or cell death by a gradient effect and dose-dependent manner. The combined effect of the targeted mechanism of FTS as a Ras inhibitor together with the localized and controlled release characteristics of the fiber is an advantageous antiproliferative quality. It is therefore suggested that our drug-eluting fibers may be used in biomedical applications that require short release (restenosis) or prolonged release (cancer therapy). 相似文献
30.
Oren-Shabtai Meital Sloutsky Nadezhda Lapidoth Moshe Mimouni Daniel Chorny Ilia Snast Igor Leshem Yael Anne Friedland Rivka Hodak Emmilia Klein Ifat Agmon Yael Levi Assi 《Lasers in medical science》2022,37(7):2899-2905
Lasers in Medical Science - Actinic keratoses are common cutaneous lesions with a potential to progress to invasive squamous cell carcinoma. Therefore, treatment is crucial. The Tixel® is a... 相似文献