Beneficial role of intravenous calcitriol on bone mineral density in children with severe secondary hyperparathyroidism

Objectives: In this prospective study, the effect of calcitriol therapy on bone mineral density and osteopenia in patients with severe secondary hyperparathyroidism has been investigated. Materials and methods: The study was carried out on 24 chronic dialysis patients consisting of 13 boys and 11 girls, aged between 8–18 years. Patients were divided into 3 groups according to the severity of hyperparathyroidism and therapy regimens. Group I consisted of 5 patients with normal parathormon levels who did not receive calcitriol therapy. In group II and III, there were patients with secondary hyperparathyroidism. Group II consisted of 10 patients receiving oral calcitriol therapy. Group III consisted of 9 patients receiving intravenous (IV) calcitriol. Bone mineral density was measured by dual energy x-ray absorptiometry. Osteopenia was defined as a Z-score worse than −2. Bone mineral density was assessed as baseline and at the end of one year. Results: A significant improvement was observed in Z-score in the group III whereas the mean value of Z-score tended to be worse in group I and it was not significantly different in group II from the initial values. The better Z-score in group III was associated with more effective stabilization of alkaline phosphatase level and bone specific alkaline phosphatases (BAP) concentrations. Conclusion: Significant improvement of Z-score in group III suggested the beneficial role in IV administration of calcitriol in chronic dialysis patients. This revised version was published online in August 2006 with corrections to the Cover Date.     

Myocardial bridging on MDCT

OBJECTIVE: The aim of this study is to show the usefulness of MDCT in the diagnosis of myocardial bridging. Although most of the time myocardial bridging is a benign condition, it may be associated with myocardial ischemia and secondary complications. Therefore, it is important to be able diagnose the presence of myocardial bridging. CONCLUSION: MDCT is an effective noninvasive method for the diagnosis of myocardial bridging because MDCT can show the length and the depth of the tunneled artery and the diameter and percentage of stenosis in the segments showing myocardial bridging in the systolic and diastolic phases. Moreover, MDCT is efficient in showing the presence of other coronary artery, myocardial, epicardial, and neighboring thoracic abnormalities.     

Imaging of hepatic steatosis and fatty sparing

Radiology has gained importance in the non-invasive diagnosis of hepatic steatosis. Ultrasonography is usually the first imaging modality for the evaluation of hepatic steatosis. Unenhanced CT with or without dual kVp measurement and MRI with in and out of phase sequence can allow objective evaluation of hepatic steatosis. However, none of the imaging modalities can differentiate non-alcoholic steatohepatitis/fatty liver disease from simple steatosis. Evaluation of hepatic steatosis is important in donor evaluation before orthotopic liver transplantation and hepatic surgery. Recently, one-stop shop evaluation of potential liver donors has become possible by CT and MRI integrating vascular, parenchymal, volume and steatosis evaluation. Moreover hepatic steatosis (diffuse, multinodular, focal, subcortical, perilesional, intralesional, periportal and perivenular), hypersteatosis and sparing (geographic, nodular and perilesional or peritumoral) can cause diagnostic problems as a pseudotumor particularly in the evaluation of oncology patients. Liver MRI is used as a problem-solving tool in these patients. In this review, we discuss the current role of radiology in diagnosing, quantifying hepatic steatosis and solutions for diagnostic problems associated with fatty infiltration and sparing.     

Impact of scanning direction on heart rate at certain levels of heart in electrocardiogram-gated 16-multidetector computed tomography angiography of coronary artery bypass grafts

OBJECTIVE: To assess impact of scanning direction on heart rates at certain levels of heart in electrocardiogram-gated 16-multidetector computed tomography (MDCT) detection of coronary artery bypass grafts and native coronary arteries. METHODS: Ninety patients with 219 grafts were studied by 16-MDCT. Forty-five patients were scanned craniocaudally. The remaining 45 patients were scanned caudocranially. Heart rates at each level were noted and compared between the 2 groups. RESULTS: The difference between mean heart rates of craniocaudal and caudocranial groups was found to be statistically significant at midcardiac, internal mammary artery origin, and cardiac base levels (P < 0.05). For the remaining levels, there was no statistically significant difference in mean heart rates. CONCLUSIONS: Performing electrocardiogram-gated 16-MDCT angiography for the evaluation of coronary arteries and bypass grafts in caudocranial direction provides lower heart rate at midcardiac and cardiac base levels of the heart, which are more prone to motion artifacts.     

Efficacy of transvaginal contrast-enhanced MRI in the early staging of cervical carcinoma

The objective of this study was to evaluate the efficacy of transvaginal contrast for local staging of cervical carcinoma. Fifty patients diagnosed with cervical carcinoma prospectively underwent magnetic resonance (MR) imaging before and after vaginal opacification (VO) with a mixture of 25 ml saline and 25 ml barium. T2-weighted (T2W) TSE images in axial and sagittal planes were compared before and after vaginal opacification. Dynamic T1W images in sagittal and fat-suppressed T1W images in transverse planes were also evaluated after intravenous contrast administration. Involvement of vaginal wall, lumen, and fornices; parametrium; rectum; and bladder were noted. Changes in local tumor staging and in treatment planning were also assessed after vaginal opacification. MR results were later compared with surgical pathological findings. Twenty-eight patients who went through surgical staging were included in the study. VO did not change any of the MR interpretations in 14 patients (50%). Correct staging was achieved with T2W TSE images with and without VO (in sagittal and transverse planes) in 78.5% and 50% of the patients, respectively. VO correctly lowered staging in seven and increased it in three patients compared with sagittal standard T2W images. Treatment planning was also changed in four (14%) of these patients. When overall accuracy of MR staging to indicate the appropriate treatment was evaluated, patients would have received the proper treatment in 90% and 79% of the cases when only T2W sagittal images with and without VO were evaluated, respectively. Dynamic gradient-echo images in sagittal planes and postcontrast T1W images in transverse planes evaluated with T2W series after VO, accomplished correct staging in 23 (82%) of the patients. MRI staging in early cervical cancer may be difficult and overestimated, especially if the tumor is slightly extended into the proximal vagina. Use of vaginal contrast medium is an easy, well-tolerated, and effective method to better delineate the borders of the tumor. It increases the specificity and accuracy of MR staging by showing the exact relation of the tumor with the vaginal wall and beyond.     

Combination of extremity computed tomography angiography and abdominal imaging in patients with musculoskeletal tumors

PURPOSE: To introduce a comprehensive computed tomography (CT) protocol for the evaluation of patients with musculoskeletal tumors by combining extremity CT angiography and abdomen CT in a dynamic multidetector CT study. METHODS: Single contrast bolus was used for each study in 4 patients with musculoskeletal tumors involving the lower extremities. Extremity CT angiography and abdominal CT were acquired sequentially by 4-channel multidetector CT. Technical parameters for extremity CT angiography were as follows: detector collimation, 4 mm x 1 mm; pitch, 1.75; slice thickness, 1.25 mm; reconstruction interval, 1 mm; coverage, 42 cm; and table speed, 14 mm/s. Thick and thin maximum intensity projections, volume renderings, and multiplanar reformats with or without bone subtraction were used to display vascular supply of the extremity mass and adjacent vascular structures. RESULTS: Satisfactory images of the extremity arterial system and abdomen were obtained in all patients. The mean delay time for CT angiography was 25 seconds. Extremity CT angiography demonstrated feeding arteries of a fibular giant cell tumor and a large lymphomatous mass. The same protocol was used for the evaluation of a distal tibial osteosarcoma and a fibular chondrosarcoma. In 2 patients, early venous return was noted, indicating vascularity of the tumors. In all patients, the relation of osseus masses to adjacent vascular structures was visualized as well as the bony anatomy. CONCLUSION: Extremity CT angiography and abdominal staging CT can be combined in a single dynamic multidetector CT protocol in patients with musculoskeletal tumors, resulting in a reduction of costs, acquisition time, and contrast dose as well as an improvement in patient management. The same protocol can also be used in trauma patients.     

Clinical anatomy of hepatic vessels by computed tomography angiography: A minireview

The liver has a complex vascular anatomy with a unique dual blood supply. Clinical conditions of the liver vary widely and include disorders originating in the vascular and biliary systems as well as the parenchyma. In most vascular disorders, the effects on the liver are generally subclinical because of its abundant blood supply. However, early diagnosis of such vascular diseases can significantly reduce patient morbidity and mortality. Because imaging findings of vascular disease are not always readily apparent, diagnosis can be difficult. Computed tomography angiography is an excellent imaging modality for visualizing the vascular anatomy of patients for treatment planning. In this review article, we focus on the vascular anatomy of the liver and the imaging findings in some acute hepatic vascular diseases.     

Imaging in secondary tumors of the ovary

Abdominal Radiology - Metastatic involvement of the ovaries is not rare. The most common tumor types metastasizing to the ovaries, from non-gynecological organs, are breast, colorectal, gastric,...