全文获取类型
收费全文 | 452篇 |
免费 | 33篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 33篇 |
妇产科学 | 25篇 |
基础医学 | 61篇 |
口腔科学 | 17篇 |
临床医学 | 42篇 |
内科学 | 108篇 |
皮肤病学 | 8篇 |
神经病学 | 26篇 |
特种医学 | 18篇 |
外科学 | 45篇 |
综合类 | 10篇 |
预防医学 | 15篇 |
眼科学 | 22篇 |
药学 | 16篇 |
中国医学 | 2篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 4篇 |
2022年 | 8篇 |
2021年 | 13篇 |
2020年 | 7篇 |
2019年 | 12篇 |
2018年 | 24篇 |
2017年 | 14篇 |
2016年 | 20篇 |
2015年 | 17篇 |
2014年 | 20篇 |
2013年 | 29篇 |
2012年 | 38篇 |
2011年 | 31篇 |
2010年 | 22篇 |
2009年 | 20篇 |
2008年 | 40篇 |
2007年 | 47篇 |
2006年 | 33篇 |
2005年 | 37篇 |
2004年 | 22篇 |
2003年 | 20篇 |
2002年 | 8篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1995年 | 2篇 |
1985年 | 1篇 |
排序方式: 共有493条查询结果,搜索用时 46 毫秒
481.
482.
Serpil Muge Deger Mehmet Akif Ozturk Mehmet D. Demirag Selcuk Aslan Berna Goker Seminur Haznedaroglu A. Mesut Onat 《Rheumatology international》2011,31(5):623-628
The aim of the present study was to investigate the health-related quality of life (HRQOL) and mood conditions in familial
Mediterranean fever (FMF) patients. Ninety FMF patients (F/M 60/30, median age 29) and 67 control subjects (F/M 46/21, median
age 30) were included in this study. HRQOL was assessed with short form-36 (SF-36) and mood conditions were assessed with
hospital anxiety depression scale (HADS). FMF patients had significantly lower mean scores on SF-36 physical components compared
to the control group. However, mental components were comparable between groups. FMF patients were significantly more likely
to have depression and anxiety compared to the control group [30 (33%) vs. 8 (12%), respectively, χ
2 = 9.58, OR (95% CI) = 3.7 (1.5–8.7), p < 0.01 for depression and 48 (53%) and 11 (16%), respectively, χ
2 = 22.31, OR (95% CI) = 5.8 (2.7–12.5), p < 0.001 for anxiety]. When frequency of anxious subjects was adjusted for the presence of concomitant depressive status as
a confounding factor, the difference between the groups remained statistically significant [χ
2 = 11.86, OR (95% CI) = 5.4 (2.1–13.7), p < 0.01]. However, the difference of depression status between groups was not statistically significant when adjusted for
the presence of concomitant anxiety status [χ
2 = 0.08, OR (95% CI) = 1.3 (0.5–3.8), p = 0.78] and FMF was found to be independently associated with only anxiety [OR (95% CI) = 7.1 (2.3–20.3)]. In addition, pure
anxious FMF subgroup had significantly lower scores of mental health and mental component summary when compared to normal
mood subgroup. In conclusion, FMF might adversely affect HRQOL. Depression and anxiety are more frequent in FMF patients than
healthy subjects. 相似文献
483.
Figen Barut Aykut Barut Banu Dogan Gun Nilufer Onak Kandemir Erol Aktunc Muge Harma Mehmet Ibrahim Harma Sukru Oguz Ozdamar 《Pathology, research and practice》2010
Ischemia, hypoxia, and elevated vascular resistance disturb placental functions by increasing oxidative stress. Heat shock protein 70 (HSP70) is an oxidative stress marker. Endothelial nitric oxide synthase (eNOS) is a nitric oxide enzyme with a key role in pathologic and physiologic angiogenesis and vasculogenesis. This study was performed to investigate the role of oxidative stress in the pathogenesis of preeclampsia and intrauterine growth-restricted (IUGR) pregnancies by comparing the levels of HSP70 and eNOS in placentas from women with these diseases and those with healthy pregnancies. 相似文献
484.
485.
Stella Anifantaki Tuncay Muge Filiz Athanasios Alegakis Pinar Topsever Adelais Markaki Nursan Dede Cinar Frangiskos Sofras Christos Lionis 《Quality of life research》2009,18(10):1311-1319
Objective
Numerous studies have identified a reduced health-related quality of life (QoL) in patients with urinary incontinence (UI). The aim of this study was to assess and compare QoL in women with UI in the island of Crete, Greece, and in Turkey. 相似文献486.
Xu F Finley TD Turkaydin M Sung Y Gurkan UA Yavuz AS Guldiken RO Demirci U 《Biomaterials》2011,32(31):7847-7855
Microscale hydrogels find widespread applications in medicine and biology, e.g., as building blocks for tissue engineering and regenerative medicine. In these applications, these microgels are assembled to fabricate large complex 3D constructs. The success of this approach requires non-destructive and high throughput assembly of the microgels. Although various assembly methods have been developed based on modifying interfaces, and using microfluidics, so far, none of the available assembly technologies have shown the ability to assemble microgels using non-invasive fields rapidly within seconds in an efficient way. Acoustics has been widely used in biomedical arena to manipulate droplets, cells and biomolecules. In this study, we developed a simple, non-invasive acoustic assembler for cell-encapsulating microgels with maintained cell viability (>93%). We assessed the assembler for both microbeads (with diameter of 50?μm and 100?μm) and microgels of different sizes and shapes (e.g., cubes, lock-and-key shapes, tetris, saw) in microdroplets (with volume of 10?μL, 20?μL, 40?μL, 80?μL). The microgels were assembled in seconds in a non-invasive manner. These results indicate that the developed acoustic approach could become an enabling biotechnology tool for tissue engineering, regenerative medicine, pharmacology studies and high throughput screening applications. 相似文献
487.
488.
489.
Akdemir Ozisik P Oruckaptan H Ozdemir Geyik P Misirlioglu M Sargon MF Kilinc K Ozgen T 《Surgical neurology》2007,68(5):547-55; discussion 555
BACKGROUND: The purpose of this study was to investigate the effect of EPO on LPO, on ultrastructural findings, and on antiapoptotic bcl-2 and survivin gene expressions after TBI. The authors also compared the activity of EPO with that of MPSS. METHODS: Wistar rats were divided into 6 groups: sham-operated, control, moderate TBI-alone (300 g/cm), TBI + EPO-treated (1000 IU/kg), TBI + MPSS-treated (30 mg/kg), and TBI + vehicle-treated (0.4 mL albumin solution) groups. RESULTS: Compared with the levels in control and sham-operated animals, LPO was significantly elevated in rats in the trauma-alone group. The administration of EPO and MPSS significantly decreased the LPO levels (P < .05). Trauma also increases the antiapoptotic bcl-2 gene expression significantly at 24 hours postinjury (P < .05), but it has no effect on survivin expression. The EPO and MPSS treatments caused significant elevation in both gene expressions (P < .05). It is also showed that MPSS has more protective effect than EPO on brain ultrastructure, especially on the structure of small- (P < .05) and medium-sized myelinated axons, after TBI. CONCLUSIONS: EPO has protective effects after moderate TBI, and this effect seems better than MPSS on antiapoptotic gene expression and LPO. The protection of cerebral subcellular organelles after traumatic injury is more prominent in MPSS-treated animals than EPO-treated animals quantitatively. This experimental study indicates that the benefits of EPO in the management of TBI have promising results and prompts further studies on the difference between EPO and MPSS in histopathological findings at the subcellular level. 相似文献
490.
In this report, we investigated the distribution of histologic types of lung cancer by age in Turkey. Among 1354 lung cancer cases diagnosed in Social Security Agency Okmeydani Hospital, Istanbul, Turkey, we included 912 male cases with data on age, smoking status, and histopathologic type. We calculated the smoking-adjusted risk for histopathologic types by age. A majority of the cases were between 45 and 64 years of age (70.5%). The smoking-adjusted risk of squamous cell carcinoma increased with advancing age, while the risk of small cell carcinoma decreased with age. The risk of small cell carcinoma was 1.6 times higher among men younger than 45 years of age compared to older men (odds ratios (OR): 1.6, 95% confidence intervals (CI): 1.1-2.3). In conclusion, we found a significant decreasing trend for small cell carcinoma by increasing age, which resulted with an excess risk among men younger than age 45. 相似文献