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431.
Wegener’s granulomatosis (WG) is a systemic necrotizing vasculitis of unknown etiology characterized mainly by the involvement
of the upper airways, lungs, and kidneys. Although most organ systems can be involved, gastrointestinal involvement in WG
is notably uncommon. We herein present the case of a WG patient who developed two massive gastrointestinal hemorrhages treated
respectively by surgery and angiographic embolization of the bleeding artery. The present case indicates that gastrointestinal
manifestations might thus be considered in the natural history of WG. 相似文献
432.
Kang Z Liu L Spangler R Spear C Wang C Gulen MF Veenstra M Ouyang W Ransohoff RM Li X 《The Journal of neuroscience》2012,32(24):8284-8292
Cuprizone inhibits mitochondrial function and induces demyelination in the corpus callosum, which resembles pattern III lesions in multiple sclerosis patients. However, the molecular and cellular mechanism by which cuprizone induces demyelination remains unclear. Interleukin-17 (IL-17) secreted by T helper 17 cells and γδT cells are essential in the development of experimental autoimmune encephalomyelitis. In this study, we examined the importance of IL-17 signaling in cuprizone-induced demyelination. We found that mice deficient in IL-17A, IL-17 receptor C (IL-17RC), and adaptor protein Act1 (of IL-17R) all had reduced demyelination accompanied by lessened microglial and polydendrocyte cellular reactivity compared with that in wild-type mice in response to cuprizone feeding, demonstrating the essential role of IL-17-induced Act1-mediated signaling in cuprizone-induced demyelination. Importantly, specific deletion of Act1 in astrocytes reduced the severity of tissue injury in this model, indicating the critical role of CNS resident cells in the pathogenesis of cuprizone-induced demyelination. In cuprizone-fed mice, IL-17 was produced by CNS CD3(+) T cells, suggesting a source of IL-17 in CNS upon cuprizone treatment. 相似文献
433.
Ozdemir D Baykara B Aksu I Kiray M Sisman AR Cetin F Dayi A Gurpinar T Uysal N Arda MN 《Neuroscience letters》2012,507(1):84-89
It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. 相似文献
434.
435.
Stella Anifantaki Tuncay Muge Filiz Athanasios Alegakis Pinar Topsever Adelais Markaki Nursan Dede Cinar Frangiskos Sofras Christos Lionis 《Quality of life research》2009,18(10):1311-1319
Objective
Numerous studies have identified a reduced health-related quality of life (QoL) in patients with urinary incontinence (UI). The aim of this study was to assess and compare QoL in women with UI in the island of Crete, Greece, and in Turkey. 相似文献436.
In this report, we investigated the distribution of histologic types of lung cancer by age in Turkey. Among 1354 lung cancer cases diagnosed in Social Security Agency Okmeydani Hospital, Istanbul, Turkey, we included 912 male cases with data on age, smoking status, and histopathologic type. We calculated the smoking-adjusted risk for histopathologic types by age. A majority of the cases were between 45 and 64 years of age (70.5%). The smoking-adjusted risk of squamous cell carcinoma increased with advancing age, while the risk of small cell carcinoma decreased with age. The risk of small cell carcinoma was 1.6 times higher among men younger than 45 years of age compared to older men (odds ratios (OR): 1.6, 95% confidence intervals (CI): 1.1-2.3). In conclusion, we found a significant decreasing trend for small cell carcinoma by increasing age, which resulted with an excess risk among men younger than age 45. 相似文献
437.
Amyand’s hernia is a very rare condition with a presence of a vermiform appendix in an inguinal hernia sac. It is estimated
to be found in approximately 1% of adult inguinal hernia. In this study, we report a retrospective analysis of 30 patients
aged between 19 days and 8 years with an Amyand’s hernia operated in our institution from 1998 to 2009, and we reviewed the
literature on the topic. Hernia repair without an appendectomy was performed in patients with normal appendix. Emergency appendectomy
through herniotomy was performed in cases of inflamed and perforated appendices. 相似文献
438.
The Serum Endothelın-1 Level in Steatosıs and NASH, and Its Relatıon wıth Severıty of Lıver Fıbrosıs
Endothelin-1 (ET-1) is known to play an important role in hepatic fibrosis. ET-1 is also a mediator that is elevated in conditions
such as insulin resistance, hyperglycemia, oxidative stress, and endothelial cell dysfunction. In this study, we investigated
whether ET-1 has a role in determining the severity of liver fibrosis in NASH. Also, the relation between ALT levels, obesity,
diabetes, and AST/ALT ratio and fibrosis and ET-1 level was sought. A total of 92 patients were enrolled in the study. The
patients were categorized into three groups: group 1, patients with elevated transaminase levels who were diagnosed as NASH
by liver biopsy (n=40); group II, patients with only hepatosteatosis determined by biopsy but having elevated transaminase levels (n=12); and group III, patients with hepatosteatosis observed by ultrasonography, having normal transaminase levels (n=40). The serum ET-1 level was measured by an appropriate ELISA kit for all patients. Mean serum ET-1 level was statistically
significantly higher in the NASH group compared to the other two groups (15.56±4.63 vs 6.75±2.46 and 5.74±2.34 μmol/L; P < 0.01). Mean serum ET-1 levels in NASH patients with grade I, grade II, and grade IV fibrosis were 14.06±0.92, 17.70±2.32,
and 20.40±1.40 μmol/L, respectively. None of the patients were identified as grade III fibrosis. It was found that the serum
ET-1 level showed a statistically significant increase as fibrosis severity increased in NASH patients (P < 0.05). In conclusion, the serum ET-1 level is higher in NASH patients compared to patients having only steatosis. There
appears to be a correlation between severity of fibrosis and serum ET-1 level in NASH patients. It has been found that NASH
patients having a twofold increase in their ALT levels had higher ET-1 levels and a more severe grade of fibrosis. 相似文献
439.
Merih Cetinkaya Gokhan Buyukkale Muge Payasli Sibel Ozbek Sultan Kavuncuoglu 《The Brazilian journal of infectious diseases》2013,17(2):260-262
Acute scrotal abscess is a rare condition in neonates. Most of these abscesses were reported to be unilateral and caused by Staphylococcus and Salmonella spp. Herein, we report a bilateral scrotal abscess in a preterm infant and Candida albicans was isolated from the scrotal fluid culture. To our knowledge, this is the first bilateral scrotal abscess in a preterm infant caused by C. albicans. Therefore, this organism must be suspected in differential diagnosis of acute scrotal abscess in neonates, especially in preterm infants. 相似文献
440.
Figen Barut Aykut Barut Banu Dogan Gun Nilufer Onak Kandemir Erol Aktunc Muge Harma Mehmet Ibrahim Harma Sukru Oguz Ozdamar 《Pathology, research and practice》2010
Ischemia, hypoxia, and elevated vascular resistance disturb placental functions by increasing oxidative stress. Heat shock protein 70 (HSP70) is an oxidative stress marker. Endothelial nitric oxide synthase (eNOS) is a nitric oxide enzyme with a key role in pathologic and physiologic angiogenesis and vasculogenesis. This study was performed to investigate the role of oxidative stress in the pathogenesis of preeclampsia and intrauterine growth-restricted (IUGR) pregnancies by comparing the levels of HSP70 and eNOS in placentas from women with these diseases and those with healthy pregnancies. 相似文献