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101.
Fahid Tariq Rasul Zane Jaunmuktane Akbar Ali Khan Rahul Phadke Michael Powell 《Acta neurochirurgica》2014,156(1):141-146
Plurihormonal pituitary adenomas are tumours that show immunoreactivity for more than one hormone that cannot be explained by normal adenohypophysial cytodifferentiation. The most common combinations in these adenomas include growth hormone (GH), prolactin (PRL) and one or more glycoprotein hormone sub-units (β-TSH, β-FSH, β-LH and αSU). The authors report two cases of a plurihormonal pituitary adenoma expressing the rare combination of ACTH and GH. They both underwent successful transphenoidal hypophysectomy (TSH). Long-term post-operative follow-up revealed no evidence of tumour recurrence. Due to the multiple secretions and plurihormonal characteristics clinical diagnosis of composite pituitary adenomas can be difficult. The authors discuss the diagnosis and management of composite pituitary adenomas and review the literature regarding this rare phenomenon. 相似文献
102.
Adil Farooq Wali Sabhiya Majid Shabhat Rasool Samar Bassam Shehada Shahad Khalid Abdulkareem Aimen Firdous Saba Beigh Sheeba Shakeel Saima Mushtaq Imra Akbar Hassan Madhkali Muneeb U. Rehman 《Saudi Pharmaceutical Journal》2019,27(6):767-777
Marine natural products have as of now been acknowledged as the most important source of bioactive substances and drug leads. Marine flora and fauna, such as algae, bacteria, sponges, fungi, seaweeds, corals, diatoms, ascidian etc. are important resources from oceans, accounting for more than 90% of the total oceanic biomass. They are taxonomically different with huge productive and are pharmacologically active novel chemical signatures and bid a tremendous opportunity for discovery of new anti-cancer molecules. The water bodies a rich source of potent molecules which improve existence suitability and serve as chemical shield against microbes and little or huge creatures. These molecules have exhibited a range of biological properties antioxidant, antibacterial, antitumour etc. In spite of huge resources enriched with exciting chemicals, the marine floras and faunas are largely unexplored for their anticancer properties. In recent past, numerous marine anticancer compounds have been isolated, characterized, identified and are under trials for human use. In this write up we have tried to compile about marine-derived compounds anticancer biological activities of diverse flora and fauna and their underlying mechanisms and the generous raise in these compounds examined for malignant growth treatment in the course of the most recent quite a long while. 相似文献
103.
Mehrnoush Kosaryan Mandana Zafari Abbass Alipur Akbar Hedayatizadeh-Omran 《Hemoglobin》2014,38(4):262-271
Hydroxyurea (HU) is being used for patients with transfusion-dependent β-thalassemia major (β-TM) as well as non transfusion-dependent β-TM. As controversy exists regarding efficacy and safety of HU, we searched the published literature on efficacy, effectiveness and toxicity of HU in patients with β-TM. The research sources we used were: Medline, SID, PubMed, Scopus, Request, Web of Knowledge, Springer, Ovid, Cochrane searched up to October 2012. Using search terms sensitive to studies of clinical trials combined with searches on terms related to thalassemia and HU. We selected studies on randomized trials, quasi experimental trials (before and after design), case reports (with 1–5 cases), side effect studies in patients with β-TM, studies related to the mechanism of action and toxicity when used in patients with other hemoglobinopathies. We researched studies in English and Persian. Eligible articles were reviewed by two independent reviewers. Patient’s characteristics, duration of trial, outcome and side effects were extracted. The main outcomes were synthesized under a random-effects model. Heterogeneity was assessed using the Q statistic, Tau2 and I2. Subgroup analyses were performed and the statistics data (STATA) software used. More than 500 articles were reviewed. No randomized clinical trial was found. Seventeen trials with before and after designs were found, 16 case reports (1–5 cases), 19 articles for mechanism of action and 16 studies for side effects were published from 1969 to October 2012. Hemoglobin levels after treatment showed modest but significant increase in non transfusion-dependent β-TM (p?0.0001) and in transfusion-dependent β-TM (p?0.0001). 相似文献
104.
The chalcones derived from o-alkynylacetophenones and aromatic aldehydes (yne-enones) when heated under reflux with iodine in acetic acid gave a range of benzo[a]fluorenone derivatives in moderate to good yields. The transformation involves the formation of a vinyl indenone intermediate through regioselective alkyne hydration and intramolecular aldol condensation followed by electrocyclic ring closure and aromatization.An iodine mediated synthesis of benzo[a]fluorenone derivatives from the chalcones derived from o-alkynylacetophenones and aromatic aldehydes is described. 相似文献
105.
Majid Misbah Masood Akbar Masoodi Shariq Rashid Naykoo Niyaz Ahmad Shah Idrees A Nissar Bushra Khan Nuzhat Shaheen ul Afshan Falaque Ganai Bashir Ahmad 《International journal of diabetes in developing countries.》2020,40(4):518-524
International Journal of Diabetes in Developing Countries - The present study aimed to evaluate the expression of microRNA-155 (miR-155) in type 2 diabetes mellitus (T2DM) and assess its... 相似文献
106.
Harvey J. Armbrecht Akbar M. Siddiqui Michael Green Susan A. Farr Vijaya B. Kumar William A. Banks Ping Patrick Gul N. Shah John E. Morley 《Neurobiology of aging》2014
The senescence-accelerated mouse (SAMP8) strain exhibits decreased learning and memory and increased amyloid beta (Aβ) peptide accumulation at 12 months. To detect differences in gene expression in SAMP8 mice, we used a control mouse that was a 50% cross between SAMP8 and CD-1 mice and which showed no memory deficits (50% SAMs). We then compared gene expression in the hippocampus of 4- and 12-month-old SAMP8 and control mice using Affymetrix gene arrays. At 12 months, but not at 4 months, pathway analysis revealed significant differences in the long term potentiation (6 genes), phosphatidylinositol signaling (6 genes), and endocytosis (10 genes) pathways. The changes in long term potentiation included mitogen-activated protein kinase (MAPK) signaling (N-ras, cAMP responsive element binding protein [CREB], protein phosphatase inhibitor 1) and Ca-dependent signaling (inositol triphosphate [ITP] receptors 1 and 2 and phospholipase C). Changes in phosphatidylinositol signaling genes suggested altered signaling through phosphatidylinositol-3-kinase, and Western blotting revealed phosphorylation changes in serine/threonine protein kinase AKT and 70S6K. Changes in the endocytosis pathway involved genes related to clathrin-mediated endocytosis (dynamin and clathrin). Endocytosis is required for receptor recycling, is involved in Aβ metabolism, and is regulated by phosphatidylinositol signaling. In summary, these studies demonstrate altered gene expression in 3 SAMP8 hippocampal pathways associated with memory formation and consolidation. These pathways might provide new therapeutic targets in addition to targeting Aβ metabolism itself. 相似文献
107.
108.
Hamid Kharatzadeh Mousa Alavi Abolfazl Mohammadi Denis Visentin Michelle Cleary 《Nursing & health sciences》2020,22(2):445-453
Professional quality of life is related to psychological well‐being for nurses with implications for quality patient care. This study evaluated the effectiveness of emotional regulation training on depression, anxiety and stress, and professional quality of life for intensive and critical care nurses. In this experimental comparison trial, 60 intensive and critical care nurses were randomly assigned to treatment and wait‐list control groups. The treatment group received six sessions of emotional regulation training, while the wait‐list control group received no treatment. Outcome measures were: the Cognitive Emotion Regulation Questionnaire; the Depression, Anxiety and Stress Scale; and the Professional Quality of Life Scale in a pre‐post design. The treatment group demonstrated greater improvements in burnout and compassion satisfaction compared with the wait‐list control group. No significant reduction in compassion fatigue was found compared with controls. Some cognitive coping strategies improved in the treatment group compared with controls, with greater reductions in depression, anxiety, and stress. This study indicates the benefits of implementing emotional regulation training programs to improve psychological well‐being and professional quality of life for intensive and critical care nurses. 相似文献
109.
Muhammad Irfan Sharjeel Waqas Ushtar Arshad Javed Akbar Khan Stanislaw Legutko Izabela Kruszelnicka Dobrochna Ginter-Kramarczyk Saifur Rahman Anna Skrzypczak 《Materials》2022,15(5)
Membrane fouling is a major hindrance to widespread wastewater treatment applications. This study optimizes operating parameters in membrane rotating biological contactors (MRBC) for maximized membrane fouling through Response Surface Methodology (RSM) and an Artificial Neural Network (ANN). MRBC is an integrated system, embracing membrane filtration and conventional rotating biological contactor in one individual bioreactor. The filtration performance was optimized by exploiting the three parameters of disk rotational speed, membrane-to-disk gap, and organic loading rate. The results showed that both the RSM and ANN models were in good agreement with the experimental data and the modelled equation. The overall R2 value was 0.9982 for the proposed network using ANN, higher than the RSM value (0.9762). The RSM model demonstrated the optimum operating parameter values of a 44 rpm disk rotational speed, a 1.07 membrane-to-disk gap, and a 10.2 g COD/m2 d organic loading rate. The optimization of process parameters can eliminate unnecessary steps and automate steps in the process to save time, reduce errors and avoid duplicate work. This work demonstrates the effective use of statistical modeling to enhance MRBC system performance to obtain a sustainable and energy-efficient treatment process to prevent human health and the environment. 相似文献
110.
Amid the COVID-19 pandemic, a sudden surge in the production and utilization of disposable, single-use facial masks has been observed. Delinquency in proper disposal of used facial masks endangers the environment with a new form of non-biodegradable plastic waste that will take hundreds of years to break down. Therefore, there is an urgent need for the resourceful recycling of such waste in an environmentally friendly way. This study presents an efficient solution by using waste masks in fibered or crushed form to produce environmentally friendly and affordable green concrete. This investigation assessed the mechanical and durability properties of waste masks-incorporated concrete. A total of six mixes were prepared for standardized tests to determine compressive strength, split cylinder tensile strength and rapid chloride penetration test (RCPT), and freeze-thaw resistance. The percentage of mask fibers used were 0.5, 1, 1.5, and 2% of concrete by volume, while crushed masks were used at 0.5% only. The mask waste in both forms was found suitable to be used in concrete. One percent of waste mask fibers was found as an optimum value to increase compressive and tensile strength, reduce chloride permeability, and increase freeze-thaw resistance. Besides this, 0.5% crushed mask fiber also performed well, especially for producing less permeable and highly durable concrete. It is thus corroborated that waste masks that increase pollution worldwide can be utilized sustainably to help build green buildings. By reutilizing waste masks to produce improved concrete with better strengths and higher durability, circular economy and sustainability are achieved, along with efficient waste management. 相似文献