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71.
Agnes E. La Ville Rosa Solà Claude Motta Núria Plana Mercedes Heras Josep Ribalta Lluís Masana 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1997,11(5):653-658
The effects of bezafibrate, a well-used fibric acid hypolipidemic agent, were investigated in 10 moderately hypertriglyceridemic
patients. The aim was to quantify the physico-chemical modifications to high-density lipoprotein subfraction 3 (HDL3) induced by treatment and to assess, in vitro, the alterations in its principal physiological function, the efflux of intracellular
free cholesterol. Treatment (200mg/thrice/d for 3 months) resulted in a 48% decrease in plasma triglycerides, with an increase
in the HDL cholesterol, due mainly to an increase in the HDL3 (P < 0.01). Composition analysis of HDL3indicated an increase in cholesterol esters (P < 0.01), free cholesterol (P < 0.01), and phospholipids (P < 0.01), coupled
with a decrease in the protein content of the molecule compared with pretreatment values. Fluorescense anisotropy at 24°C
was significantly higher post-treatment than pretreatment (P < 0.01). The cholesterol effluxing capacity of pretreatment HDL3 was 28%, and post-treatment this increased to 50% (P < 0.01). Multivariate analyses indicated that the increased capacity
of HDL3 to promote free cholesterol efflux was, in part, due to increased HDL3 phospholipid content and a more adequate fluidity of the molecule. These findings suggest that bezafibrate induces a lowering
of plasma triglycerides and that the resultant physico-chemical alterations of the HDL3 molecule make it more efficient as an acceptor of intracellular free cholesterol.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
72.
Antonio Lombardo Sergio Scavino Giovanni Scornavacca Giuseppe Oliva Costantino Sipione Rossella Cacciola Luciano Motta 《Acta diabetologica》1986,23(1):1-12
Summary The authors report data obtained from a 3-year study of CSII and humanized insulin (semi-synthetic human insulin) administered
to 18 insulin-dependent subjects in the outpatient clinic. The aim of this study was to evaluate the validity of insulin pumps
in long-term treatment. Metabolic parameters were significantly improved (p<0.001) in the first month and remained so with
only slight alterations throughout treatment. The authors underline some metabolic problems (ketosis) caused by malfunctioning
of the insulin pumps, by the difficulties with the infusion sytem or by nodular skin lesions at the infusion site. Only these
lesions called for treatment to be discontinued in 4 patients. The highest incidence of nodular skin lesions was seen after
one year’s uninterrupted treatment and they seem connected to the duration of treatment rather than to the patients’ negligence
(inadequate hygiene, delayed needle substitution). The authors conclude that CSII treatment is valid over short-term periods,
whereas it presents drawbacks over long-term administration. 相似文献
73.
M Tanabe M Okazaki M Okazaki S Kobayashi N Kaneko T Sekiguchi S Tateno S R Motta T Takeuchi 《Revista do Instituto de Medicina Tropical de S?o Paulo》1990,32(2):121-131
Sera from the patients (N = 10) with schistosomiasis mansoni of the hospital of Federal University of Pernambuco, the Schistosoma mansoni egg-positive (N = 51) and -negative (N = 452) inhabitants in Cabo City area, out-patients (N = 37) of the IMIP hospital and Japanese immigrants (N = 127) in Petrolina City area of northeast Brazil as well as Japanese healthy subjects (N = 30) were examined by serological tests including an enzyme-linked immunosorbent assay with antigens prepared from eggs (ELISA-egg) and adult worms (ELISA-adult). The ELISA with egg or adult antigen correctly identified 100% of the uninfected individuals lived in non-endemic area of schistosomiasis. Moreover, when examined cross-reactivity of our ELISA with sera isolated from 78 subjects infected with various intestinal parasitic infections, only one of these sera reacted with the egg and adult antigens. On the examination of 51 sera from the egg-positive subjects, the ELISA-egg revealed the highest sensitivity (98.0%), whereas a large number of false negative reactions of ELISA-adult, Ouchterlony method using adult antigen, circumoval precipitation and immediate intradermal skin test were observed. A low sensitivity of these serologic tests except for ELISA-egg appears to be primarily due to their inability to detect antibody in the sera from egg-positive infantiles. There was no positive correlation between the absorbance values of these two types of ELISA among the sera isolated from ELISA-positive subjects. Rather, by the reactivity of these sera to egg or adult antigen, they could be divided into two subgroups; one reacted more positively with egg antigen and the other with adult antigen. Moreover, it was confirmed that the sera from young subjects (under 20 years old) appear to be highly reactive to the egg antigen than did aged ones. These data suggest that the ELISA with egg antigen, but not with the adult antigen, appears to be useful for the serological survey of schistosomiasis mansoni in the endemic area of northeast Brazil. 相似文献
74.
Ishiguro A; Spirin KS; Shiohara M; Tobler A; Gombart AF; Israel MA; Norton JD; Koeffler HP 《Blood》1996,87(12):5225-5231
75.
R S Valdez J A Motta E London R P Martin W L Haskell J W Farquhar R L Popp L Horlick 《Circulation》1979,60(4):921-929
An asymptomatic adult population of 196 men and women was studied with the echocardiogram to derive age- and sex-specific "normal" values for a number of clinically used echocardiograhic variables. The results are in general agreement with previously published normal values. Body position during the examination, age and sex influence the echocardiographic results; body surface area correction normalized most of these effects. The prevalence of occult abnormalities determined by the echocardiogram is 7%; the most common finding was mitral valve prolapse. Inter- and intraobserver variability was assessed. The interobserver differences found on analysis are statistically, but not clinically , significant. The echocardiogram appears to be a suitable tool to use in epidemiologic studies to detect selected cardiac abnormalities, but is limited for this purpose because some subjects in such a population cannot be adequately examined. 相似文献
76.
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79.
Átila V. V. Nobre Tábata L. S. Pólvora Letícia R. M. Silva Vanessa de O. Teles Kelly Vargas Villafuerte Raphael J. G. da Motta João H. P. Fortes Gilberto A. Silva Ana Laura P. Ranieri Leandro D. de Macedo Karen M. L. Morejon Benedito A. L. da Fonseca Camila Tirapelli Maria C. P. Saraiva Mário Taba Jr. Alan G. Lourenço Ana Carolina F. Motta 《Journal of periodontology》2019,90(2):167-176
80.
Lorenza Magliano Melania Patalano Alessandra Sagliocchi Marianna Scutifero Antonella Zaccaro Maria Grazia D’Angelo Federica Civati Erika Brighina Giuseppe Vita Gian Luca Vita Sonia Messina Maria Sframeli Marika Pane Maria Elena Lombardo Roberta Scalise Adele D’Amico Giulia Colia Michela Catteruccia Umberto Balottin Angela Berardinelli Maria Chiara Motta Corrado Angelini Alessandra Gaiani Claudio Semplicini Luca Bello Roberta Battini Guja Astrea Giulia Ricci Luisa Politano 《Journal of neurology》2014,261(1):188-195
This paper focuses on the psychological benefits of caregiving in key relatives of patients with muscular dystrophies (MD), a group of rare diseases characterized by progressive weakness and restriction of the patient’s functional abilities. We describe whether relatives perceived caregiving to be a positive experience and test whether relatives’ perceptions vary in relation to their view of the patient as a valued person, the degree of involvement in care, and the level of support provided by social network and professionals. The study sample included 502 key relatives of patients aged 4–25 years, suffering from Duchenne, Becker, or limb-girdle MD, in treatment for at least 6 months to one of the eight participating centers, living with at least one relative aged 18–80 years. Of key relatives, 88 % stated that they had gotten something positive out of the situation, 96 % considered their patients to be sensitive, and 94 % viewed their patients as talented. Positive aspects of caregiving were more recognized by key relatives who were more convinced that the patient was sensitive and who perceived that they received higher level of professional help and psychological social support. These results suggest that most key relatives consider that their caregiving experience has had a positive impact on their lives, despite the practical difficulties of caring for patients with MD. Professionals should help relatives to identify the benefits of caregiving without denying its difficulties. Clinicians themselves should develop positive attitudes towards family involvement in the care of patients with long-term diseases. 相似文献