First Aid Treatment of Electric Shock

The mode of death was determined in the 82 electrocutions as being either asphyxial or cardiac in type. Using the information obtained from the electrocutions, the functional response in the 7,724 electrical accidents was determined. From this, the relative success of the first aid treatments was decided.

External cardiac massage with mouth-to-mouth artificial respiration was a failure even when applied to the cases with ventricular fibrillation. Only four cases of recovery from ventricular fibrillation following electric shock are known. Mouth-to-mouth artificial respiration compared very unfavorably with the older manual methods.

It is recommended that the first aid treatment of electric shock be reevaluated. The recommended treatment should consist of two blows on the chest followed by a manual method of artificial respiration. In electric shock, external cardiac massage with mouth-to-mouth artificial respiration should not be recommended for use by first aid personnel.     

On-Pump Beating Heart Surgery Offers an Alternative for Unstable Patients Undergoing Coronary Artery Bypass Grafting

Abstract Background: Cardiac surgery has expanded the available approaches to aortocoronary artery bypass grafting to include approaches from minimally invasive surgery to full sternotomy. The heart can be arrested, left beating, or assisted with a right ventricular assist device or cardiopulmonary bypass pump. We have examined the 4 surgical modes that we use routinely in our large multisurgeon practice to determine our selection biases and the outcomes of the different techniques. Methods: Of the 4733 coronary artery bypass grafting (CABG) patients we studied from January 2000 through December 2002, 2332 (49.3%) operations were done on-pump on the arrested heart, 1908 (40.3%) were performed off-pump, 364 (7.7%) were performed on-pump on the beating heart, and 129 (2.7%) were performed with right heart assist. The preoperative risk factors, operative variables, and postoperative outcomes of the groups were analyzed. Results: Patients selected for on-pump beating heart procedures tended to be sicker with the highest predicted risk of death. We also selected patients who were in cardiogenic shock, in resuscitation, in emergent or salvage status, on dialysis, and with preoperative intra-aortic balloon pump (IABP) use for on-pump beating heart procedures at higher than expected rates. Patients with renal failure with or without dialysis, and those having a history of cerebrovascular accident tended not to be chosen for on-pump arrested heart procedures. Off-pump beating heart procedures were avoided for patients with cardiogenic shock or resuscitation, in emergent or salvage status, and with preoperative IABP use. The mortality rate in these patients was slightly worse in the on-pump beating heart group (4.4%) than in the on-pump arrested heart (3.5%) and off-pump (2.3%) groups (analysis of variance [ANOVA], P =.04). Atrial fibrillation occurred more frequently in both the on-pump beating heart (20.1%) and on-pump arrested heart (23.8%) groups (ANOVA, P <.001). The on-pump groups had higher rates of blood product use and reoperation for bleeding and a prolonged ventilation rate, compared with the other procedures. On-pump patients had a statistically longer length of stay than either off-pump or right heart-assisted patients ( P <.05) and required longer times on the ventilator and in the intensive care unit. Conclusions: Normothermic cardiopulmonary bypass with a beating heart is safe and efficacious and may be the method of choice for patients in cardiogenic shock, requiring resuscitation, or with previous CABG surgery, recent myocardial infarction, a low ejection fraction, or unstable arrhythmias.     

Minactivin expression in human monocyte and macrophage populations

Adherent monolayer cultures of human blood monocytes, peritoneal macrophages, bone marrow macrophages, and colonic mucosa macrophages were examined for their ability to produce and secrete minactivin, a specific inactivator of urokinase-type plasminogen activator. All except colonic mucosa macrophages produced and secreted appreciable amounts of minactivin, but only blood monocytes were stimulated by muramyl dipeptide (adjuvant peptide) to increase production. The minactivin from each of these populations could be shown to preferentially inhibit urokinase-type plasminogen activator and not trypsin, plasmin, or "tissue"-type plasminogen activator (HPA66). A plasminogen-activating enzyme present in monocyte cultures appeared unaffected by the presence of minactivin and could be shown to be regulated independently by dexamethasone.     

Treatment of facial lipodystrophy syndromes. Lipofilling versus free flap surgery

Facial lipodystrophies are characterized by a progressive atrophy of the subcutaneous fat of the face. The aim of our study, which includes two types of facial lipodystrophy (Barraquer–Simons (BS) and Parry–Romberg (PR) syndromes), was to compare the results of treatment with lipofilling and with free flaps and to evaluate the long-term outcome. Eighteen patients (seven cases of BS and 11 cases of PR), issued from four different plastic surgery departments, underwent surgery from 1986 to 2004. The average follow-up period was 5.25 years. Of seven patients who had free flap surgery, four presented satisfying results and three bad results. Dissatisfaction in this group was mainly due to ptosis and a partial atrophy of the flaps. Three good and nine excellent results were seen in patients treated with lipofilling. The results in this group were technique-related, with the nine patients treated with lipostructure (Coleman’s technique) presenting the best outcome. Lipofilling, as an alternative of free flaps, seems to offer superior results. This technique is simple, not expensive, and minor compared to free tissue transfer. It allows the treatment of two areas in one-stage procedure without leaving scars. Lipostructure fills all the conditions to become the technique of choice in the treatment of facial lipodystrophies.     

Does traumatic brain injury result in accelerated fracture healing?

In patients who have sustained a traumatic brain injury with an associated extremity fracture there is often a clinical perception that the rate of new bone formation around the fracture site is increased. Whether this rapidly forming new bone is fracture callus or a variant of heterotopic ossification, a common complication of traumatic brain injury, is the subject of some debate. This review will provide a comprehensive analysis on this topic and will discuss clinical and physiological evidence as well as potential areas for future research in this field.     

A new, recurrent mutation of GJB3 (Cx31) in erythrokeratodermia variabilis

BACKGROUND: Erythrokeratodermia variabilis (EKV) is an autosomal dominant or recessive genodermatosis characterized by the coexistence of randomly occurring, transient, erythematous patches and hyperkeratosis of the skin. The disorder has been mapped to chromosome 1p35.1 but is genetically heterogeneous. EKV may be caused by pathogenic mutations in one of two neighbouring connexin genes, GJB3 and GJB4, encoding the gap junction proteins Cx31 and Cx30.3, respectively. Twelve distinct mutations identified to date cluster either at the cytoplasmic amino-terminus or in the four transmembrane domains. OBJECTIVES: To report a large family with EKV and an unrelated sporadic case. METHODS: DNA amplification and mutation analysis, followed by denaturing high-performance liquid chromatography to confirm the segregation of the mutations in the two families with EKV. RESULTS: A novel, recurrent GJB3 mutation (625C-->T; L209F) was identified in the family with EKV and in the unrelated sporadic case. CONCLUSIONS: This mutation is the first to affect a conserved residue in the cytoplasmic carboxy-terminus of any connexin gene with a cutaneous phenotype, emphasizing its structural and/or functional importance.